The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Toll/interleukin-1 receptor homology (TIR) domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1X-linked interleukin-1 receptor accessory protein-like 1Myeloid differentiation primary response protein MyD88TIR domain-containing adapter molecule 1SC:2Disease resistance protein (TIR-NBS-LRR class)phosphoinositide 3-kinase adapter protein 1Toll/interleukin-1 receptor domain-containing adapter proteinDisease resistance protein (TIR-NBS-LRR class)Uncharacterized proteinToll-like receptor 2Interleukin 1 receptor accessory proteinToll-like receptor 7Toll-like receptor 4Toll-like receptor 3X-linked interleukin-1 receptor accessory protein-like 1single Ig IL-1-related receptor isoform X1Sterile alpha and TIR motif-containing proteinSterile alpha and TIR motif containing 1TIR domain-containing adapter molecule 2Disease resistance protein (TIR-NBS class)B cell scaffold protein with ankyrin repeats 1p-loop containing nucleoside triphosphate hydrolase superfamily protein18w proteinBlast:Protein tollToll receptor 13Myd88Sterile alpha and TIR motif-containing protein tir-1Toll-like receptor 2Toll-6Protein kinase family proteinTOLl (Drosophila) familyToll-like receptor 5bputative ST2L protein isoform X4AGAP001590-PBToll-4TehaoSterile alpha and TIR motif containing 1Disease resistance protein (TIR-NBS-LRR class) familyinterleukin-18 receptor 1 isoform X3Putative serine/threonine-protein kinase pats1Uncharacterized proteinToll-like receptor 1Phosphoinositide-3-kinase adaptor protein 1Disease resistance protein CHS1Toll-like receptor adaptor molecule 1Uncharacterized proteinPutative phosphoinositide 3-kinase adapter protein 1Uncharacterized proteinUncharacterized proteinInterleukin-1 receptor type IUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinToll-like receptor2Uncharacterized proteinUncharacterized proteinDisease resistance protein (TIR-NBS-LRR class) familyPutative serine/threonine-protein kinase pats1Disease resistance protein (TIR-NBS class)Toll-Interleukin receptorTransmembrane receptors / ATP binding proteinPredicted proteinInterleukin 1 receptor accessory proteinUncharacterized protein PHLOEM PROTEIN 2-LIKE A7Uncharacterized proteinUncharacterized proteinUncharacterized proteinToll-like receptor 9Uncharacterized proteinToll-like receptor 19Uncharacterized proteinUncharacterized proteinUncharacterized proteinMyeloid differentiation factor 88Uncharacterized proteinTIR-domain containing adaptor inducing INF-betaUncharacterized proteinInterleukin 1 receptor accessory protein-like 2Uncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinProtein CBG03616Uncharacterized proteinProtein tirAUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized protein
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FunFam 14: TIR domain-containing adapter molecule 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q86XR7 (/IPI) Q8BJQ4 (/IPI)
Interleukin-1 receptor binding GO:0005149
Interacting selectively and non-covalently with the interleukin-1 receptor.
1 Q8BJQ4 (/ISO)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
1 Q8BJQ4 (/IDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q8BJQ4 (/ISO)
Showing 1 to 4 of 4 entries

There are 33 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
2 Q86XR7 (/IMP) Q8BJQ4 (/IMP)
Positive regulation of toll-like receptor 4 signaling pathway GO:0034145
Any process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway.
2 Q2LGB7 (/ISS) Q8BJQ4 (/ISS)
TRAM-dependent toll-like receptor 4 signaling pathway GO:0035669
Any series of molecular signals generated as a consequence of binding to a toll-like receptor 4 where the TRAM adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.
2 Q2LGB7 (/ISS) Q8BJQ4 (/ISS)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
2 Q2LGB7 (/ISS) Q8BJQ4 (/ISS)
Positive regulation of interleukin-18-mediated signaling pathway GO:2000494
Any process that activates or increases the frequency, rate or extent of interleukin-18-mediated signaling pathway.
2 Q86XR7 (/IMP) Q8BJQ4 (/IMP)
Regulation of cytokine production GO:0001817
Any process that modulates the frequency, rate, or extent of production of a cytokine.
1 Q8BJQ4 (/IMP)
MyD88-independent toll-like receptor signaling pathway GO:0002756
Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
1 Q86XR7 (/TAS)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
1 Q8BJQ4 (/ISO)
I-kappaB kinase/NF-kappaB signaling GO:0007249
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
1 Q86XR7 (/TAS)
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
1 Q8BJQ4 (/IMP)
Showing 1 to 10 of 33 entries

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
2 Q2LGB7 (/ISS) Q8BJQ4 (/ISS)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
2 Q2LGB7 (/ISS) Q8BJQ4 (/ISS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
2 Q2LGB7 (/ISS) Q8BJQ4 (/ISS)
Phagocytic cup GO:0001891
An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.
1 Q86XR7 (/IDA)
Phagocytic cup GO:0001891
An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.
1 Q8BJQ4 (/ISO)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 Q8BJQ4 (/IDA)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
1 Q8BJQ4 (/ISO)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
1 Q8BJQ4 (/ISO)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q8BJQ4 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8BJQ4 (/IDA)
Showing 1 to 10 of 16 entries
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