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CATH Superfamily 3.40.50.1010

5'-nuclease

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
5'-nuclease
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1rRNA-processing protein UTP23 homolog20S-pre-rRNA D-site endonuclease NOB1Ribonuclease VapCRibonuclease VapCRibonuclease VapCToxin FitBRibonuclease VapC1SC:2Exosome complex exonuclease DIS3telomerase-binding protein EST1A isoform X1protein SMG5 isoform X2SC:3Flap endonuclease 1Flap endonuclease XniExonuclease 1DNA polymerase IExonuclease 1, putativerRNA-processing protein FCF1 homologATP-binding proteinPhoH family proteinMeiosis regulator and mRNA stability factor 1Constitutive coactivator of PPAR-gamma-like protein 1SWT1, RNA endoribonuclease homologConstitutive coactivator of peroxisome proliferator-activated receptor gammaFlap endonuclease 1Flap endonuclease 1RNA-binding protein NOB1U3 small nucleolar RNA-associated protein 24DIS3-like exonuclease 1 isoform X1DNA repair protein complementing XP-G cells homologDNA repair protein complementing XP-G cellsflap endonuclease GEN homolog 1DNA repair protein RAD220S-pre-rRNA D-site endonuclease NOB15'-3' exonuclease family protein5'-3' exonuclease family proteinDNA repair protein UVH3flap endonuclease GEN-like 2DNA repair protein UVH3Flap endonuclease GEN-like 1Blast:Protein SMG5Ribonuclease HFcf1, putativeEndonuclease, putativeRad2-like endonuclease, putative (AFU_orthologue AFUA_3G13260)Exosome complex exonuclease RRP44rRNA-processing protein FCF1 family proteinDNA repair protein complementing XP-G cellsUnplaced genomic scaffold supercont1.259, whole genome shotgun sequenceRibonuclease VapCMKT1 domain-containing proteinDNA repair endonucleaseTranscriptional protein swt1RAD2p Single-stranded DNA endonucleaseBlast:Telomerase-binding protein EST1ARibonuclease VapCDNA repair endonuclease, putativeRNA-binding protein NOB1, putativeRad2-like endonuclease, putative (AFU_orthologue AFUA_3G13260)Exosome complex exonuclease RRP44Protein MKT1Flap endonuclease GENExodeoxyribonuclease IXUnplaced genomic scaffold supercont1.1, whole genome shotgun sequenceUnplaced genomic scaffold supercont1.23, whole genome shotgun sequenceFlap endonuclease 1Putative 5'-3' exonuclease, N-terminal resolvase-like domainDNA repair protein RAD2Single-stranded DNA endonuclease (Eurofung)rRNA processing protein, putativeRibonuclease VapCDNA polymerase IMitochondrial structure specific endonuclease I (SSE-1)Flap endonuclease 1DNA repair endonucleaseRibonuclease VapCRibonuclease VapCPutative 5'-3' exonucleaseRibonuclease VapCRibonuclease VapCRibonuclease VapCRibonuclease VapCRibonuclease VapCRibonuclease VapCRibonuclease VapCUncharacterized proteinrRNA processing Fcf1 Family ProteinRibonuclease VapCRibonuclease VapCRibonuclease VapCExonucleaseYKR096W-like proteinUnplaced genomic scaffold supercont2.30, whole genome shotgun sequenceUnplaced genomic scaffold supercont1.6, whole genome shotgun sequenceexosome complex exonuclease RRP44 isoform X2Nin one binding protein-like proteinYen1pExonuclease, putativeRibonuclease VapCDNA polymerase IAGAP008671-PARibonuclease VapCDNA polymerase IProtein CBR-EXO-1Exonuclease I, putativeExosome complex exonuclease RRP44, putativePilT protein domain proteinUncharacterized proteinUncharacterized proteinRibonuclease VapCRibonuclease VapCPhohExonuclease 1ERCC excision repair 5, endonucleaseDNA repair protein RAD2, putativerRNA-processing protein FCF1Mitotic control protein dis3Forkhead-associated (FHA) domain-containing proteinPosttranscriptional regulation nuclease (Mkt1), putative (AFU_orthologue AFUA_5G12250)Expressed proteinFamily with sequence similarity 120BNYN domain-containing protein20S-pre-rRNA D-site endonuclease NOB1DNA repair enzymeUncharacterized proteinPredicted proteinDNA-repair protein putativePutative rrp44p homologuePutative endonuclease or glycosyl hydrolaseNucleic acid binding protein, putative6-hydroxy-3-succinoylpyridine hydroxylaseTegument host shutoff proteinFlap endonuclease XniExonucleasePhosphate starvation protein PhoHUnplaced genomic scaffold supercont1.6, whole genome shotgun sequenceDNA-repair protein, putativeFlap endonuclease 1-1Protein CBG02516Uncharacterized proteinGH28353pWGS project CABT00000000 data, contig 2.11Crossover junction endodeoxyribonucleaseDNA polymerase IPredicted proteinExonuclease 1Flap endonuclease 1RNA-binding protein NOB1
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FunFam 205:

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Ribonuclease activity GO:0004540
Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
 1 G5ECF1 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 1 G5ECF1 (/IPI)
DEAD/H-box RNA helicase binding GO:0017151
Interacting selectively and non-covalently with the enzyme DEAD/H-box RNA helicase.
 1 G5ECF1 (/IPI)
Protein phosphatase regulator activity GO:0019888
Modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.
 1 G5ECF1 (/NAS)
Protein phosphatase 2A binding GO:0051721
Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.
 1 G5ECF1 (/IPI)
Showing 1 to 5 of 5 entries

There are 4 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184
The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
 1 G5ECF1 (/IMP)
RNA interference GO:0016246
The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.
 1 G5ECF1 (/IMP)
Embryonic genitalia morphogenesis GO:0030538
The process, occurring in the embryo, by which the anatomical structures of the genitalia are generated and organized.
 1 G5ECF1 (/IMP)
NcRNA metabolic process GO:0034660
The chemical reactions and pathways involving non-coding RNA transcripts (ncRNAs).
 1 G5ECF1 (/IMP)
Showing 1 to 4 of 4 entries

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
 1 G5ECF1 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
 1 G5ECF1 (/IDA)
Showing 1 to 2 of 2 entries
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