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CATH Superfamily 3.40.50.1000

HAD superfamily/HAD-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
HAD superfamily/HAD-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 513: Glucosyl-3-phosphoglycerate/mannosyl-3-phosphoglyc...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Mannosyl-3-phosphoglycerate phosphatase. [EC: 3.1.3.70]
2-O-(alpha-D-mannosyl)-3-phosphoglycerate + H(2)O = 2-O-(alpha-D- mannosyl)-D-glycerate + phosphate.
  • The enzyme from Pyrococcus horikoshii is specific for alpha-D- mannosyl-3-phosphoglycerate and forms part of the pathway for the synthesis of mannosylglycerate.
 2 C0QRP9 Q12XX5
Glucosyl-3-phosphoglycerate phosphatase. [EC: 3.1.3.85]
2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate + H(2)O = 2-O-(alpha- D-glucopyranosyl)-D-glycerate + phosphate.
  • The enzyme is involved in biosynthesis of 2-O-(alpha-D- glucopyranosyl)-D-glycerate via the two-step pathway in which EC 2.4.1.266 catalyzes the conversion of GDP-glucose and 3-phospho-D- glycerate into 2-O-(alpha-D-glucopyranosyl)-3-phospho-D-glycerate, which is then converted to 2-O-(alpha-D-glucopyranosyl)-D-glycerate by glucosyl-3-phosphoglycerate phosphatase.
  • In vivo the enzyme catalyzes the dephosphorylation of 2-O-(alpha-D- mannopyranosyl)-3-phospho-D-glycerate with lower efficiency.
  • Divalent metal ions (Mg(2+), Mn(2+) or Co(2+)) stimulate activity.
 2 C0QRP9 Q12XX5
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