The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
HAD superfamily/HAD-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: HAD-IIB family hydrolase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1630 A1A8B5 (/ISS) A1A8B5 (/ISS) A1A8B5 (/ISS) A1A8B5 (/ISS) A1A8B5 (/ISS) A1A8B5 (/ISS) A1A8B5 (/ISS) A1A8B5 (/ISS) A1A8B5 (/ISS) A1A8B5 (/ISS)
(1620 more)
Phosphatase activity GO:0016791
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
1627 A1A8B5 (/ISS) A1A8B5 (/ISS) A1A8B5 (/ISS) A1A8B5 (/ISS) A1A8B5 (/ISS) A1A8B5 (/ISS) A1A8B5 (/ISS) A1A8B5 (/ISS) A1A8B5 (/ISS) A1A8B5 (/ISS)
(1617 more)
Sugar-phosphatase activity GO:0050308
Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate.
225 P0A8Y6 (/ISS) P0A8Y6 (/ISS) P0A8Y6 (/ISS) P0A8Y6 (/ISS) P0A8Y6 (/ISS) P0A8Y6 (/ISS) P0A8Y6 (/ISS) P0A8Y6 (/ISS) P0A8Y6 (/ISS) P0A8Y6 (/ISS)
(215 more)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
201 P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA)
(191 more)
Phosphatase activity GO:0016791
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
182 P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA)
(172 more)
Sugar-phosphatase activity GO:0050308
Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate.
171 P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA)
(161 more)
Pyridoxal phosphatase activity GO:0033883
Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.
41 P21829 (/IDA) P21829 (/IDA) P21829 (/IDA) P21829 (/IDA) P21829 (/IDA) P21829 (/IDA) P21829 (/IDA) P21829 (/IDA) P21829 (/IDA) P21829 (/IDA)
(31 more)
Phosphotransferase activity, alcohol group as acceptor GO:0016773
Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).
21 P21829 (/IDA) P21829 (/IDA) P21829 (/IDA) P21829 (/IDA) P21829 (/IDA) P21829 (/IDA) P21829 (/IDA) P21829 (/IDA) P21829 (/IDA) P21829 (/IDA)
(11 more)
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
20 P27848 (/IDA) P27848 (/IDA) P27848 (/IDA) P27848 (/IDA) P27848 (/IDA) P27848 (/IDA) P27848 (/IDA) P27848 (/IDA) P27848 (/IDA) P27848 (/IDA)
(10 more)
5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity GO:0043726
Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate.
19 P75809 (/IDA) P75809 (/IDA) P75809 (/IDA) P75809 (/IDA) P75809 (/IDA) P75809 (/IDA) P75809 (/IDA) P75809 (/IDA) P75809 (/IDA) P75809 (/IDA)
(9 more)
Nucleoside-diphosphatase activity GO:0017110
Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate.
11 P46891 (/IDA) P46891 (/IDA) P46891 (/IDA) P46891 (/IDA) P46891 (/IDA) P46891 (/IDA) P46891 (/IDA) P46891 (/IDA) P46891 (/IDA) P46891 (/IDA)
(1 more)
Pyridoxal phosphatase activity GO:0033883
Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.
3 Q8X8L6 (/ISS) Q8X8L6 (/ISS) Q8X8L6 (/ISS)
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
3 Q8X8L6 (/ISS) Q8X8L6 (/ISS) Q8X8L6 (/ISS)
Endoribonuclease activity GO:0004521
Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks.
2 Q8L5Z4 (/IDA) Q8L5Z4 (/IDA)
Phosphatase activity GO:0016791
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
2 O94314 (/ISM) Q9UTA6 (/ISM)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
222 P0A8Y6 (/ISS) P0A8Y6 (/ISS) P0A8Y6 (/ISS) P0A8Y6 (/ISS) P0A8Y6 (/ISS) P0A8Y6 (/ISS) P0A8Y6 (/ISS) P0A8Y6 (/ISS) P0A8Y6 (/ISS) P0A8Y6 (/ISS)
(212 more)
Riboflavin biosynthetic process GO:0009231
The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
19 P75809 (/IDA) P75809 (/IDA) P75809 (/IDA) P75809 (/IDA) P75809 (/IDA) P75809 (/IDA) P75809 (/IDA) P75809 (/IDA) P75809 (/IDA) P75809 (/IDA)
(9 more)
Thiamine biosynthetic process GO:0009228
The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
11 P46891 (/IMP) P46891 (/IMP) P46891 (/IMP) P46891 (/IMP) P46891 (/IMP) P46891 (/IMP) P46891 (/IMP) P46891 (/IMP) P46891 (/IMP) P46891 (/IMP)
(1 more)
Antibiotic catabolic process GO:0017001
The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms.
11 P46891 (/IDA) P46891 (/IDA) P46891 (/IDA) P46891 (/IDA) P46891 (/IDA) P46891 (/IDA) P46891 (/IDA) P46891 (/IDA) P46891 (/IDA) P46891 (/IDA)
(1 more)
Chloroplast organization GO:0009658
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast.
2 Q8L5Z4 (/IMP) Q8L5Z4 (/IMP)
Chloroplast rRNA processing GO:1901259
Any rRNA processing that takes place in chloroplast.
2 Q8L5Z4 (/IMP) Q8L5Z4 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
152 P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA) P0A8Y5 (/IDA)
(142 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O94314 (/HDA) Q9UTA6 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O94314 (/HDA) Q9UTA6 (/HDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
2 Q8L5Z4 (/IDA) Q8L5Z4 (/IDA)
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