The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
HAD superfamily/HAD-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 108: Phospholipid-transporting ATPase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P32660 (/IPI) P32660 (/IPI) Q12675 (/IPI) Q12675 (/IPI)
ATPase-coupled intramembrane lipid transporter activity GO:0140326
Catalysis of the movement of lipids from one membrane leaflet to the other, using energy from the hydrolysis of ATP. This includes flippases and floppases.
4 P32660 (/IGI) P32660 (/IGI) Q12675 (/IGI) Q12675 (/IGI)
ATPase-coupled intramembrane lipid transporter activity GO:0140326
Catalysis of the movement of lipids from one membrane leaflet to the other, using energy from the hydrolysis of ATP. This includes flippases and floppases.
4 P32660 (/IMP) P32660 (/IMP) Q12675 (/IMP) Q12675 (/IMP)
Ion transmembrane transporter activity, phosphorylative mechanism GO:0015662
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate.
2 P32660 (/IMP) P32660 (/IMP)
Ion transmembrane transporter activity, phosphorylative mechanism GO:0015662
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate.
2 P32660 (/ISS) P32660 (/ISS)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to pheromone triggering conjugation with cellular fusion GO:0000749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that positively regulates the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.
4 P32660 (/IGI) P32660 (/IGI) Q12675 (/IGI) Q12675 (/IGI)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
4 P32660 (/IGI) P32660 (/IGI) Q12675 (/IGI) Q12675 (/IGI)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
4 P32660 (/IMP) P32660 (/IMP) Q12675 (/IMP) Q12675 (/IMP)
Establishment or maintenance of cell polarity GO:0007163
Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
4 P32660 (/IGI) P32660 (/IGI) Q12675 (/IGI) Q12675 (/IGI)
Phospholipid translocation GO:0045332
The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
4 P32660 (/IGI) P32660 (/IGI) Q12675 (/IGI) Q12675 (/IGI)
Phospholipid translocation GO:0045332
The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
4 P32660 (/IMP) P32660 (/IMP) Q12675 (/IMP) Q12675 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
3 Q2KG18 (/IMP) Q2KG18 (/IMP) Q2KG18 (/IMP)
Protein retention in Golgi apparatus GO:0045053
The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known.
3 Q2KG18 (/IMP) Q2KG18 (/IMP) Q2KG18 (/IMP)
Positive regulation of exocytosis GO:0045921
Any process that activates or increases the frequency, rate or extent of exocytosis.
3 Q2KG18 (/IMP) Q2KG18 (/IMP) Q2KG18 (/IMP)
Intracellular protein transport GO:0006886
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
2 P32660 (/IGI) P32660 (/IGI)
Phospholipid translocation GO:0045332
The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
1 Q09891 (/ISO)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
5 P32660 (/HDA) P32660 (/HDA) Q09891 (/HDA) Q12675 (/HDA) Q12675 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 A0A1D8PJN3 (/IDA) P32660 (/IDA) P32660 (/IDA) Q12675 (/IDA) Q12675 (/IDA)
Cellular bud neck GO:0005935
The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
4 P32660 (/HDA) P32660 (/HDA) Q12675 (/HDA) Q12675 (/HDA)
Mating projection tip membrane GO:0070867
The portion of the plasma membrane surrounding a mating projection tip.
4 P32660 (/IDA) P32660 (/IDA) Q12675 (/IDA) Q12675 (/IDA)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
4 P32660 (/HDA) P32660 (/HDA) Q12675 (/HDA) Q12675 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P32660 (/HDA) P32660 (/HDA)
Phospholipid-translocating ATPase complex GO:1990531
A protein complex that functions as a phospholipid-translocating P-Type ATPase.
2 P32660 (/IPI) P32660 (/IPI)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q09891 (/ISO)
Phospholipid-translocating ATPase complex GO:1990531
A protein complex that functions as a phospholipid-translocating P-Type ATPase.
1 Q09891 (/ISO)
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