The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 3: Aldehyde dehydrogenase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 33 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
13 E9Q3E1 (/IDA) J3QMK6 (/IDA) P30838 (/IDA) P47739 (/IDA) P47740 (/IDA) P51648 (/IDA) Q70DU8 (/IDA) Q70DU8 (/IDA) Q80VQ0 (/IDA) Q80VQ0 (/IDA)
(3 more)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
9 P11883 (/ISS) P47739 (/ISS) Q70DU8 (/ISS) Q70DU8 (/ISS) Q70E96 (/ISS) Q70E96 (/ISS) Q70E96 (/ISS) Q8W033 (/ISS) Q8W033 (/ISS)
Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620
Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.
9 P47739 (/IDA) Q2FWX9 (/IDA) Q2FWX9 (/IDA) Q2FWX9 (/IDA) Q2FWX9 (/IDA) Q2FWX9 (/IDA) Q2FWX9 (/IDA) Q2FWX9 (/IDA) Q2FWX9 (/IDA)
3-chloroallyl aldehyde dehydrogenase activity GO:0004028
Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.
6 A0A0F7RFH4 (/ISS) A0A0F7RFH4 (/ISS) Q70DU8 (/ISS) Q70DU8 (/ISS) Q8W033 (/ISS) Q8W033 (/ISS)
Long-chain-aldehyde dehydrogenase activity GO:0050061
Catalysis of the reaction: a long-chain aldehyde + NAD+ = a long-chain carboxylate + NADH + H+. A long-chain aldehyde is one with more than 12 carbons.
5 P30839 (/ISS) P47740 (/ISS) Q5RF60 (/ISS) Q5RF60 (/ISS) Q60HH8 (/ISS)
Medium-chain-aldehyde dehydrogenase activity GO:0052814
Catalysis of the reaction: a medium-chain aldehyde + NAD+ = a medium-chain carboxylate + NADH + H+. Medium-chain aldehydes have a chain length of between 8 and 12 carbons.
5 P30839 (/ISS) P47740 (/ISS) Q5RF60 (/ISS) Q5RF60 (/ISS) Q60HH8 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 P30838 (/IPI) P43353 (/IPI) P43353 (/IPI) P51648 (/IPI)
3-chloroallyl aldehyde dehydrogenase activity GO:0004028
Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.
3 P11883 (/IDA) P30839 (/IDA) P47739 (/IDA)
3-chloroallyl aldehyde dehydrogenase activity GO:0004028
Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.
3 P43353 (/TAS) P43353 (/TAS) P48448 (/TAS)
Aldehyde dehydrogenase [NAD(P)+] activity GO:0004030
Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.
3 P30838 (/TAS) P43353 (/TAS) P43353 (/TAS)
Showing 1 to 10 of 33 entries

There are 59 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Carotenoid biosynthetic process GO:0016117
The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail.
8 Q2FWX9 (/IDA) Q2FWX9 (/IDA) Q2FWX9 (/IDA) Q2FWX9 (/IDA) Q2FWX9 (/IDA) Q2FWX9 (/IDA) Q2FWX9 (/IDA) Q2FWX9 (/IDA)
Cellular aldehyde metabolic process GO:0006081
The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells.
6 E9Q3E1 (/IC) J3QMK6 (/IC) P47739 (/IC) P47740 (/IC) Q80VQ0 (/IC) Q80VQ0 (/IC)
Hexadecanal metabolic process GO:0046458
The chemical reactions and pathways involving hexadecanal, the C16 straight chain aldehyde.
5 P30839 (/ISS) P47740 (/ISS) Q5RF60 (/ISS) Q5RF60 (/ISS) Q60HH8 (/ISS)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
5 P30838 (/IDA) P43353 (/IDA) P43353 (/IDA) P51648 (/IDA) Q99PH4 (/IDA)
Response to abscisic acid GO:0009737
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
4 Q70DU8 (/IEP) Q70DU8 (/IEP) Q8W033 (/IEP) Q8W033 (/IEP)
Sphingolipid biosynthetic process GO:0030148
The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
4 P43353 (/TAS) P43353 (/TAS) P48448 (/TAS) P51648 (/TAS)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
4 P47739 (/ISO) P47740 (/ISO) Q80VQ0 (/ISO) Q80VQ0 (/ISO)
Alcohol metabolic process GO:0006066
The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
3 P43353 (/TAS) P43353 (/TAS) P48448 (/TAS)
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
3 P43353 (/TAS) P43353 (/TAS) P48448 (/TAS)
Cellular aldehyde metabolic process GO:0006081
The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells.
2 P30838 (/IDA) P51648 (/IDA)
Showing 1 to 10 of 59 entries

There are 39 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
8 P30838 (/IDA) P30839 (/IDA) P47740 (/IDA) Q70DU8 (/IDA) Q70DU8 (/IDA) Q70E96 (/IDA) Q70E96 (/IDA) Q70E96 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 J3QMK6 (/IDA) P11883 (/IDA) P43353 (/IDA) P43353 (/IDA) P47739 (/IDA) Q80VQ0 (/IDA) Q80VQ0 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 I3L3I9 (/IDA) P11883 (/IDA) P30838 (/IDA) P30839 (/IDA) Q80VQ0 (/IDA) Q80VQ0 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 I3L3I9 (/IDA) J3QMK6 (/IDA) P30838 (/IDA) Q80VQ0 (/IDA) Q80VQ0 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
5 Q70DU8 (/IDA) Q70DU8 (/IDA) Q70E96 (/IDA) Q70E96 (/IDA) Q70E96 (/IDA)
Plastid GO:0009536
Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
4 Q70DU8 (/ISS) Q70DU8 (/ISS) Q8W033 (/ISS) Q8W033 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P47739 (/ISO) Q80VQ0 (/ISO) Q80VQ0 (/ISO)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
2 Q70DU8 (/IDA) Q70DU8 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
2 P47739 (/ISO) P47740 (/ISO)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
2 Q70DU8 (/IDA) Q70DU8 (/IDA)
Showing 1 to 10 of 39 entries
CATH-Gene3D is a Global Biodata Core Resource Learn more...