The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Aldehyde Dehydrogenase; Chain A, domain 2
".
FunFam 2: Methylmalonate-semialdehyde dehydrogenase (Acylati...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 15 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Methylmalonate-semialdehyde dehydrogenase (acylating) activity GO:0004491
Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.
|
35 |
P52713 (/ISS)
Q02252 (/ISS)
Q02252 (/ISS)
Q07536 (/ISS)
Q17M80 (/ISS)
Q29HB2 (/ISS)
Q54I10 (/ISS)
Q723T1 (/ISS)
Q723T1 (/ISS)
Q723T1 (/ISS)
(25 more) |
|
Malonate-semialdehyde dehydrogenase (acetylating) activity GO:0018478
Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+.
|
7 | P52713 (/ISS) Q02252 (/ISS) Q02252 (/ISS) Q07536 (/ISS) Q17M80 (/ISS) Q29HB2 (/ISS) Q7KW39 (/ISS) |
|
Fatty-acyl-CoA binding GO:0000062
Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.
|
6 | P52713 (/ISS) Q02252 (/ISS) Q02252 (/ISS) Q02253 (/ISS) Q29HB2 (/ISS) Q7KW39 (/ISS) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
2 | Q02252 (/HDA) Q02252 (/HDA) |
|
Methylmalonate-semialdehyde dehydrogenase (acylating) activity GO:0004491
Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.
|
2 | Q02253 (/IDA) Q07536 (/IDA) |
|
Methylmalonate-semialdehyde dehydrogenase (acylating) activity GO:0004491
Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.
|
2 | Q02252 (/IMP) Q02252 (/IMP) |
|
Methylmalonate-semialdehyde dehydrogenase (acylating) activity GO:0004491
Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.
|
2 | Q02252 (/TAS) Q02252 (/TAS) |
|
Fatty-acyl-CoA binding GO:0000062
Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.
|
1 | Q07536 (/IDA) |
|
Methylmalonate-semialdehyde dehydrogenase (acylating) activity GO:0004491
Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.
|
1 | Q9EQ20 (/ISO) |
|
Methylmalonate-semialdehyde dehydrogenase (acylating) activity GO:0004491
Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.
|
1 | Q02253 (/NAS) |
Showing 1 to 10 of 15 entries
There are 20 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Valine catabolic process GO:0006574
The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid.
|
26 |
Q723T1 (/ISS)
Q723T1 (/ISS)
Q723T1 (/ISS)
Q81QB6 (/ISS)
Q81QR5 (/ISS)
Q81QR5 (/ISS)
Q81QR5 (/ISS)
Q81QR5 (/ISS)
Q81QR5 (/ISS)
Q81QR5 (/ISS)
(16 more) |
|
Valine metabolic process GO:0006573
The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid.
|
8 | P52713 (/ISS) Q02252 (/ISS) Q02252 (/ISS) Q07536 (/ISS) Q17M80 (/ISS) Q29HB2 (/ISS) Q7KW39 (/ISS) Q83D19 (/ISS) |
|
Beta-alanine biosynthetic process GO:0019483
The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.
|
8 | Q9I702 (/IDA) Q9I702 (/IDA) Q9I702 (/IDA) Q9I702 (/IDA) Q9I702 (/IDA) Q9I702 (/IDA) Q9I702 (/IDA) Q9I702 (/IDA) |
|
Thymine metabolic process GO:0019859
The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.
|
7 | P52713 (/ISS) Q02252 (/ISS) Q02252 (/ISS) Q07536 (/ISS) Q17M80 (/ISS) Q29HB2 (/ISS) Q7KW39 (/ISS) |
|
Thymine catabolic process GO:0006210
The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.
|
2 | Q02252 (/IMP) Q02252 (/IMP) |
|
Valine catabolic process GO:0006574
The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid.
|
2 | Q02252 (/IMP) Q02252 (/IMP) |
|
Branched-chain amino acid catabolic process GO:0009083
The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
|
2 | Q02252 (/TAS) Q02252 (/TAS) |
|
Pyrimidine nucleobase metabolic process GO:0006206
The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.
|
1 | Q7KW39 (/ISS) |
|
Thymine catabolic process GO:0006210
The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.
|
1 | Q02253 (/IDA) |
|
Thymine catabolic process GO:0006210
The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.
|
1 | Q9EQ20 (/ISO) |
Showing 1 to 10 of 20 entries
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
9 | O53816 (/HDA) O53816 (/HDA) O53816 (/HDA) O53816 (/HDA) O53816 (/HDA) O53816 (/HDA) O53816 (/HDA) O53816 (/HDA) O53816 (/HDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
6 | A0A024R6G4 (/IDA) A0A024R6G4 (/IDA) G3V4Z4 (/IDA) Q02252 (/IDA) Q02252 (/IDA) Q0WM29 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
5 | A0A024R6G4 (/IDA) A0A024R6G4 (/IDA) G3V4Z4 (/IDA) Q02252 (/IDA) Q02252 (/IDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | P52713 (/HDA) Q9EQ20 (/HDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | Q54I10 (/ISS) Q7KW39 (/ISS) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | Q02252 (/NAS) Q02252 (/NAS) |
|
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
2 | Q02252 (/TAS) Q02252 (/TAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q9EQ20 (/ISO) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q9EQ20 (/ISO) |
Showing 1 to 9 of 9 entries
