The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 12: Betaine aldehyde dehydrogenase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Aldehyde dehydrogenase [NAD(P)+] activity GO:0004030
Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.
32 P23883 (/IDA) P23883 (/IDA) P23883 (/IDA) P23883 (/IDA) P23883 (/IDA) P23883 (/IDA) P23883 (/IDA) P23883 (/IDA) P23883 (/IDA) P23883 (/IDA)
(22 more)
Betaine-aldehyde dehydrogenase activity GO:0008802
Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+.
10 O24174 (/IDA) O24174 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA) Q9STS1 (/IDA) Q9STS1 (/IDA)
Aldehyde dehydrogenase [NAD(P)+] activity GO:0004030
Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.
9 P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP)
Betaine-aldehyde dehydrogenase activity GO:0008802
Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+.
6 B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
3 P54114 (/IDA) Q9STS1 (/IDA) Q9STS1 (/IDA)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
3 Q88BC5 (/ISS) Q88BC5 (/ISS) Q88BC5 (/ISS)
Aldehyde dehydrogenase (NAD) activity GO:0004029
Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.
2 A0A1D8PSW6 (/IMP) P47771 (/IMP)
3-chloroallyl aldehyde dehydrogenase activity GO:0004028
Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.
1 Q9URW9 (/ISO)
Phenylacetaldehyde dehydrogenase activity GO:0008957
Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+.
1 O06837 (/IDA)
5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity GO:0018480
Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+.
1 Q5LLJ2 (/ISS)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Putrescine catabolic process GO:0009447
The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine.
23 P23883 (/IMP) P23883 (/IMP) P23883 (/IMP) P23883 (/IMP) P23883 (/IMP) P23883 (/IMP) P23883 (/IMP) P23883 (/IMP) P23883 (/IMP) P23883 (/IMP)
(13 more)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
11 P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) Q9S795 (/IMP)
(1 more)
NADPH regeneration GO:0006740
A metabolic process that generates a pool of NADPH by the reduction of NADP+.
9 P54115 (/IGI) P54115 (/IGI) P54115 (/IGI) P54115 (/IGI) P54115 (/IGI) P54115 (/IGI) P54115 (/IGI) P54115 (/IGI) P54115 (/IGI)
Acetate biosynthetic process GO:0019413
The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid.
9 P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP)
Cellular response to anoxia GO:0071454
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%.
8 O24174 (/IDA) O24174 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA)
Cellular response to anoxia GO:0071454
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%.
6 B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS)
Fermentation GO:0006113
The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, coupling the oxidation and reduction of NAD/H and the generation of adenosine triphosphate (ATP).
3 Q88BC5 (/ISS) Q88BC5 (/ISS) Q88BC5 (/ISS)
Polyamine catabolic process GO:0006598
The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups.
2 P47771 (/IMP) P54114 (/IMP)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
2 Q9STS1 (/IEP) Q9STS1 (/IEP)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
2 Q9S795 (/IMP) Q9S795 (/IMP)
Response to abscisic acid GO:0009737
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
2 Q9STS1 (/IEP) Q9STS1 (/IEP)
Beta-alanine biosynthetic process GO:0019483
The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.
2 P47771 (/IMP) P54114 (/IMP)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
2 Q9STS1 (/IDA) Q9STS1 (/IDA)
Cellular aldehyde metabolic process GO:0006081
The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells.
1 Q9URW9 (/IC)
Polyamine catabolic process GO:0006598
The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups.
1 Q9URW9 (/ISO)
Beta-alanine biosynthetic process GO:0019483
The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.
1 Q9URW9 (/ISO)
Catechol-containing compound catabolic process GO:0019614
The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent.
1 Q5LLJ2 (/ISS)
Styrene catabolic process GO:0042207
The chemical reactions and pathways resulting in the breakdown of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene.
1 O06837 (/IDA)
Carnitine biosynthetic process GO:0045329
The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
1 A0A1D8PSW6 (/IMP)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
12 B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) Q84LK3 (/ISS) Q84LK3 (/ISS) Q84LK3 (/ISS) Q84LK3 (/ISS)
(2 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
11 P54115 (/IDA) P54115 (/IDA) P54115 (/IDA) P54115 (/IDA) P54115 (/IDA) P54115 (/IDA) P54115 (/IDA) P54115 (/IDA) P54115 (/IDA) Q9S795 (/IDA)
(1 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
9 P54115 (/HDA) P54115 (/HDA) P54115 (/HDA) P54115 (/HDA) P54115 (/HDA) P54115 (/HDA) P54115 (/HDA) P54115 (/HDA) P54115 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
9 P54115 (/IDA) P54115 (/IDA) P54115 (/IDA) P54115 (/IDA) P54115 (/IDA) P54115 (/IDA) P54115 (/IDA) P54115 (/IDA) P54115 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
9 P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP) P54115 (/IMP)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) B3VMC0 (/ISS) P54114 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 Q84LK3 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA) Q84LK3 (/IDA)
Peroxisome GO:0005777
A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.
4 O24174 (/IDA) O24174 (/IDA) Q9STS1 (/IDA) Q9STS1 (/IDA)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
2 Q9S795 (/IDA) Q9S795 (/IDA)
Leucoplast GO:0009516
A colorless plastid involved in the synthesis of monoterpenes.
2 Q9S795 (/IDA) Q9S795 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9URW9 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P47771 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9URW9 (/HDA)
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