The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Glutaredoxin
".
FunFam 239: Iodothyronine deiodinase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Thyroxine 5'-deiodinase activity GO:0004800
Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2.
|
2 | P49897 (/TAS) P55073 (/TAS) |
|
Thyroxine 5'-deiodinase activity GO:0004800
Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2.
|
1 | Q91ZI8 (/IMP) |
|
Thyroxine 5'-deiodinase activity GO:0004800
Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2.
|
1 | P55073 (/NAS) |
|
Thyroxine 5-deiodinase activity GO:0033798
Catalysis of the reaction: 3,3',5'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.
|
1 | Q91ZI8 (/IDA) |
There are 11 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | P49897 (/IEP) |
|
Thyroid hormone generation GO:0006590
The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
|
1 | P55073 (/TAS) |
|
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
|
1 | Q91ZI8 (/IMP) |
|
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
|
1 | Q91ZI8 (/IMP) |
|
Thyroid hormone metabolic process GO:0042403
The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.
|
1 | P49897 (/TAS) |
|
Thyroid hormone catabolic process GO:0042404
The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.
|
1 | Q91ZI8 (/IDA) |
|
Thyroid hormone catabolic process GO:0042404
The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.
|
1 | Q91ZI8 (/IMP) |
|
Negative regulation of eye photoreceptor cell development GO:0042480
Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development.
|
1 | Q91ZI8 (/IMP) |
|
Retinal cone cell development GO:0046549
Development of a cone cell, one of the sensory cells in the eye that reacts to the presence of light. Cone cells contain the photopigment iodopsin or cyanopsin and are responsible for photopic (daylight) vision.
|
1 | Q91ZI8 (/IMP) |
|
Brown fat cell proliferation GO:0070342
The multiplication or reproduction of brown fat cells by cell division, resulting in the expansion of their population. A brown fat cell is a fat cell found the thermogenic form of adipose tissue found in newborns of many species.
|
1 | P49897 (/IEP) |
|
Retinal cone cell apoptotic process GO:0097474
Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina.
|
1 | Q91ZI8 (/IMP) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P55073 (/TAS) |
