The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Severin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 26: Glia maturation factor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein kinase inhibitor activity GO:0004860
Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein.
15 O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS)
(5 more)
Enzyme activator activity GO:0008047
Binds to and increases the activity of an enzyme.
15 O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS)
(5 more)
Arp2/3 complex binding GO:0071933
Interacting selectively and non-covalently with an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5).
2 Q9ERL7 (/ISO) Q9ERL7 (/ISO)
Kinase regulator activity GO:0019207
Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
1 Q80T18 (/NAS)
Arp2/3 complex binding GO:0071933
Interacting selectively and non-covalently with an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5).
1 O13808 (/IDA)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
15 O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS)
(5 more)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
15 O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS)
(5 more)
Negative regulation of Arp2/3 complex-mediated actin nucleation GO:0034316
Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins.
5 Q9ERL7 (/IDA) Q9ERL7 (/IDA) Q9VJL6 (/IDA) Q9VJL6 (/IDA) Q9VJL6 (/IDA)
Actin filament debranching GO:0071846
An actin filament severing process that results in the removal of actin filament branches specifically at the branch points.
5 Q9ERL7 (/IDA) Q9ERL7 (/IDA) Q9VJL6 (/IDA) Q9VJL6 (/IDA) Q9VJL6 (/IDA)
Border follicle cell migration GO:0007298
The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
3 Q9VJL6 (/IMP) Q9VJL6 (/IMP) Q9VJL6 (/IMP)
Regulation of actin filament polymerization GO:0030833
Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.
3 Q9VJL6 (/IMP) Q9VJL6 (/IMP) Q9VJL6 (/IMP)
Regulation of cell projection organization GO:0031344
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
3 Q9VJL6 (/IMP) Q9VJL6 (/IMP) Q9VJL6 (/IMP)
Negative regulation of Arp2/3 complex-mediated actin nucleation GO:0034316
Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins.
3 Q9VJL6 (/IGI) Q9VJL6 (/IGI) Q9VJL6 (/IGI)
Actin cortical patch assembly GO:0000147
Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells.
1 O13808 (/IMP)
Sprouting angiogenesis GO:0002040
The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.
1 Q24JU9 (/IMP)
Negative regulation of Arp2/3 complex-mediated actin nucleation GO:0034316
Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation mediated by the Arp2/3 complex and interacting proteins.
1 O13808 (/IMP)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
15 O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS)
(5 more)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
15 O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS)
(5 more)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
15 O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS) O60234 (/TAS)
(5 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q9VJL6 (/IDA) Q9VJL6 (/IDA) Q9VJL6 (/IDA)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
3 Q9VJL6 (/IDA) Q9VJL6 (/IDA) Q9VJL6 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
3 Q9VJL6 (/IDA) Q9VJL6 (/IDA) Q9VJL6 (/IDA)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
3 Q9VJL6 (/IDA) Q9VJL6 (/IDA) Q9VJL6 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O13808 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O13808 (/HDA)
Actin cortical patch GO:0030479
An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae.
1 O13808 (/IDA)
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