The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Glycine betaine-binding periplasmic protein; domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Choline ABC transporter substrate-binding protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Amine transmembrane transporter activity GO:0005275
Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group.
21 Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA)
(11 more)
Carnitine transmembrane transporter activity GO:0015226
Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
11 Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA)
(1 more)
ATPase-coupled quaternary ammonium compound transmembrane transporting activity GO:0015418
Catalysis of the reaction: ATP + H2O + quaternary ammonium(out) = ADP + H(+) + phosphate + quaternary ammonium(in).
11 Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA)
(1 more)
Choline binding GO:0033265
Interacting selectively and non-covalently with choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium.
10 Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA)
Sulfur compound transmembrane transporter activity GO:1901682
Enables the transfer of a sulfur compound from one side of a membrane to the other.
6 Q9I7A0 (/ISS) Q9I7A0 (/ISS) Q9I7A0 (/ISS) Q9I7A0 (/ISS) Q9I7A0 (/ISS) Q9I7A0 (/ISS)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Carnitine transport GO:0015879
The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
11 Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA)
(1 more)
Carnitine transport GO:0015879
The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
11 Q9HTH6 (/IMP) Q9HTH6 (/IMP) Q9HTH6 (/IMP) Q9HTH6 (/IMP) Q9HTH6 (/IMP) Q9HTH6 (/IMP) Q9HTH6 (/IMP) Q9HTH6 (/IMP) Q9HTH6 (/IMP) Q9HTH6 (/IMP)
(1 more)
Carnitine catabolic process GO:0042413
The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
11 Q9HTH6 (/IMP) Q9HTH6 (/IMP) Q9HTH6 (/IMP) Q9HTH6 (/IMP) Q9HTH6 (/IMP) Q9HTH6 (/IMP) Q9HTH6 (/IMP) Q9HTH6 (/IMP) Q9HTH6 (/IMP) Q9HTH6 (/IMP)
(1 more)
Amino-acid betaine transport GO:0015838
The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
10 Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA)
Choline transport GO:0015871
The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
10 Q9HTI6 (/IMP) Q9HTI6 (/IMP) Q9HTI6 (/IMP) Q9HTI6 (/IMP) Q9HTI6 (/IMP) Q9HTI6 (/IMP) Q9HTI6 (/IMP) Q9HTI6 (/IMP) Q9HTI6 (/IMP) Q9HTI6 (/IMP)
Glycine betaine catabolic process GO:0031457
The chemical reactions and pathways resulting in the breakdown of glycine betaine, N-trimethylglycine.
10 Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA)
Glycine betaine transport GO:0031460
The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
10 Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA)
Choline catabolic process GO:0042426
The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
10 Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA)
Carnitine transmembrane transport GO:1902603
The directed movement of carnitine across a membrane.
10 Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA) Q9HTI6 (/IDA)
Choline biosynthetic process GO:0042425
The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
6 Q9I7A0 (/ISS) Q9I7A0 (/ISS) Q9I7A0 (/ISS) Q9I7A0 (/ISS) Q9I7A0 (/ISS) Q9I7A0 (/ISS)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
ATP-binding cassette (ABC) transporter complex GO:0043190
A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
21 Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA)
(11 more)
Periplasmic space GO:0042597
The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
11 Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA) Q9HTH6 (/IDA)
(1 more)
Periplasmic space GO:0042597
The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
6 Q9I7A0 (/ISS) Q9I7A0 (/ISS) Q9I7A0 (/ISS) Q9I7A0 (/ISS) Q9I7A0 (/ISS) Q9I7A0 (/ISS)
ATP-binding cassette (ABC) transporter complex GO:0043190
A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
6 Q9I7A0 (/ISS) Q9I7A0 (/ISS) Q9I7A0 (/ISS) Q9I7A0 (/ISS) Q9I7A0 (/ISS) Q9I7A0 (/ISS)
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