The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Cytidine Deaminase, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15: Lys-63-specific deubiquitinase BRCC36 isoform 3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
14 A5PJP6 (/ISS) B0KWU8 (/ISS) B0KWU8 (/ISS) B2RYM5 (/ISS) B5X8M4 (/ISS) B5X8M4 (/ISS) P46737 (/ISS) Q4VA72 (/ISS) Q5R9L6 (/ISS) Q5R9L6 (/ISS)
(4 more)
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
14 A5PJP6 (/ISS) B0KWU8 (/ISS) B0KWU8 (/ISS) B2RYM5 (/ISS) B5X8M4 (/ISS) B5X8M4 (/ISS) P46737 (/ISS) Q4VA72 (/ISS) Q5R9L6 (/ISS) Q5R9L6 (/ISS)
(4 more)
Polyubiquitin modification-dependent protein binding GO:0031593
Interacting selectively and non-covalently with a protein upon poly-ubiquitination of the target protein.
14 A5PJP6 (/ISS) B0KWU8 (/ISS) B0KWU8 (/ISS) B2RYM5 (/ISS) B5X8M4 (/ISS) B5X8M4 (/ISS) P46737 (/ISS) Q4VA72 (/ISS) Q5R9L6 (/ISS) Q5R9L6 (/ISS)
(4 more)
Thiol-dependent ubiquitinyl hydrolase activity GO:0036459
Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin.
14 A5PJP6 (/ISS) B0KWU8 (/ISS) B0KWU8 (/ISS) B2RYM5 (/ISS) B5X8M4 (/ISS) B5X8M4 (/ISS) P46737 (/ISS) Q4VA72 (/ISS) Q5R9L6 (/ISS) Q5R9L6 (/ISS)
(4 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P46736 (/IPI) P46737 (/IPI)
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
1 P46736 (/IMP)
Thiol-dependent ubiquitin-specific protease activity GO:0004843
Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein.
1 P46737 (/ISO)
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
1 P46736 (/IMP)
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
1 P46737 (/ISO)
Enzyme regulator activity GO:0030234
Binds to and modulates the activity of an enzyme.
1 P46736 (/IDA)
Showing 1 to 10 of 16 entries

There are 25 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
14 A5PJP6 (/ISS) B0KWU8 (/ISS) B0KWU8 (/ISS) B2RYM5 (/ISS) B5X8M4 (/ISS) B5X8M4 (/ISS) P46737 (/ISS) Q4VA72 (/ISS) Q5R9L6 (/ISS) Q5R9L6 (/ISS)
(4 more)
Response to ionizing radiation GO:0010212
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.
14 A5PJP6 (/ISS) B0KWU8 (/ISS) B0KWU8 (/ISS) B2RYM5 (/ISS) B5X8M4 (/ISS) B5X8M4 (/ISS) P46737 (/ISS) Q4VA72 (/ISS) Q5R9L6 (/ISS) Q5R9L6 (/ISS)
(4 more)
Positive regulation of DNA repair GO:0045739
Any process that activates or increases the frequency, rate or extent of DNA repair.
14 A5PJP6 (/ISS) B0KWU8 (/ISS) B0KWU8 (/ISS) B2RYM5 (/ISS) B5X8M4 (/ISS) B5X8M4 (/ISS) P46737 (/ISS) Q4VA72 (/ISS) Q5R9L6 (/ISS) Q5R9L6 (/ISS)
(4 more)
Protein K63-linked deubiquitination GO:0070536
A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a protein.
14 A5PJP6 (/ISS) B0KWU8 (/ISS) B0KWU8 (/ISS) B2RYM5 (/ISS) B5X8M4 (/ISS) B5X8M4 (/ISS) P46737 (/ISS) Q4VA72 (/ISS) Q5R9L6 (/ISS) Q5R9L6 (/ISS)
(4 more)
Histone H2A K63-linked deubiquitination GO:0070537
A protein deubiquitination process in which a K63-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is removed from a lysine residue in histone H2A or the variant H2AX.
14 A5PJP6 (/ISS) B0KWU8 (/ISS) B0KWU8 (/ISS) B2RYM5 (/ISS) B5X8M4 (/ISS) B5X8M4 (/ISS) P46737 (/ISS) Q4VA72 (/ISS) Q5R9L6 (/ISS) Q5R9L6 (/ISS)
(4 more)
Signal transduction involved in G2 DNA damage checkpoint GO:0072425
A signal transduction process that contributes to a G2/M transition DNA damage checkpoint.
14 A5PJP6 (/ISS) B0KWU8 (/ISS) B0KWU8 (/ISS) B2RYM5 (/ISS) B5X8M4 (/ISS) B5X8M4 (/ISS) P46737 (/ISS) Q4VA72 (/ISS) Q5R9L6 (/ISS) Q5R9L6 (/ISS)
(4 more)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
2 A0A0R4ICH2 (/IMP) A0A0R4IER2 (/IMP)
Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
1 P46736 (/IMP)
Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
1 P46737 (/ISO)
Double-strand break repair via nonhomologous end joining GO:0006303
The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
1 P46736 (/TAS)
Showing 1 to 10 of 25 entries

There are 19 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
14 A5PJP6 (/ISS) B0KWU8 (/ISS) B0KWU8 (/ISS) B2RYM5 (/ISS) B5X8M4 (/ISS) B5X8M4 (/ISS) P46737 (/ISS) Q4VA72 (/ISS) Q5R9L6 (/ISS) Q5R9L6 (/ISS)
(4 more)
BRCA1-A complex GO:0070531
A protein complex that contains the BRCA1-BARD1 heterodimer, RAP80/UIMC1, BRCC3/BRCC36, BRE/BRCC45, FAM175A/CCDC98/Abraxas and MERIT40/NBA1, and specifically recognizes and binds K63-linked polyubiquitin chains present on histone H2A and H2AX at DNA damage sites.
14 A5PJP6 (/ISS) B0KWU8 (/ISS) B0KWU8 (/ISS) B2RYM5 (/ISS) B5X8M4 (/ISS) B5X8M4 (/ISS) P46737 (/ISS) Q4VA72 (/ISS) Q5R9L6 (/ISS) Q5R9L6 (/ISS)
(4 more)
BRISC complex GO:0070552
A protein complex that contains the FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and MERIT40/NBA1 proteins, and specifically cleaves K63-linked polyubiquitin chains.
14 A5PJP6 (/ISS) B0KWU8 (/ISS) B0KWU8 (/ISS) B2RYM5 (/ISS) B5X8M4 (/ISS) B5X8M4 (/ISS) P46737 (/ISS) Q4VA72 (/ISS) Q5R9L6 (/ISS) Q5R9L6 (/ISS)
(4 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
6 A0A087WZR3 (/IDA) A0A087WZR3 (/IDA) A0A0D9SF50 (/IDA) H9KVA9 (/IDA) H9KVA9 (/IDA) P46736 (/IDA)
Ubiquitin ligase complex GO:0000151
A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
1 P46736 (/IDA)
Ubiquitin ligase complex GO:0000151
A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
1 P46737 (/ISO)
Nuclear ubiquitin ligase complex GO:0000152
A ubiquitin ligase complex found in the nucleus.
1 P46736 (/IDA)
Nuclear ubiquitin ligase complex GO:0000152
A ubiquitin ligase complex found in the nucleus.
1 P46737 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P46736 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P46737 (/ISO)
Showing 1 to 10 of 19 entries
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