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CATH Superfamily 3.40.1190.20

Ribokinase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 40: Thiamine biosynthetic bifunctional enzyme TH1, chl...

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Thiamine phosphate synthase. [EC: 2.5.1.3]
(1) 4-amino-2-methyl-5-diphosphomethylpyrimidine + 2-((2R,5Z)-2-carboxy- 4-methylthiazol-5(2H)-ylidene)ethyl phosphate = diphosphate + thiamine phosphate + CO(2). (2) 4-amino-2-methyl-5-diphosphomethylpyrimidine + 2-(2-carboxy-4- methylthiazol-5-yl)ethyl phosphate = diphosphate + thiamine phosphate + CO(2). (3) 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5- (2-phosphono-oxyethyl)thiazole = diphosphate + thiamine phosphate.
  • The enzyme catalyzes the penultimate reaction in thiamine de novo biosynthesis, condensing the pyrimidine and thiazole components.
  • The enzyme is thought to accept the product of EC 2.8.1.10 as its substrate.
  • However, it has been shown that in some bacteria, such as Bacillus subtilis, an additional enzyme, EC 5.3.99.10 converts that compound into its tautomer 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate, and that it is the latter that serves as the substrate for the synthase.
  • In addition to this activity, the enzyme participates in a salvage pathway, acting on 4-methyl-5-(2-phosphono-oxyethyl)thiazole, which is produced from thiamine degradation products.
  • In yeast this activity is found in a bifunctional enzyme and in the plant Arabidopsis thaliana the activity is part of a trifunctional enzyme.
 10 A0A0D5N9M5 A0A0D5N9M5 A0A178W9W3 A0A178W9W3 O48881 P61422 P61422 Q2QWK9 Q5M731 Q5M731
Hydroxymethylpyrimidine kinase. [EC: 2.7.1.49]
ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2- methyl-5-(phosphomethyl)pyrimidine.
  • CTP, UTP and GTP can act as donors.
 10 A0A0D5N9M5 A0A0D5N9M5 A0A178W9W3 A0A178W9W3 O48881 P61422 P61422 Q2QWK9 Q5M731 Q5M731
Phosphooxymethylpyrimidine kinase. [EC: 2.7.4.7]
ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine = ADP + 4-amino-2- methyl-5-(diphosphooxymethyl)pyrimidine.
    		 4 A0A0D5N9M5 A0A0D5N9M5 P61422 P61422
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