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CATH Superfamily 3.40.1080.10

Glutaconate Coenzyme A-transferase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Glutaconate Coenzyme A-transferase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Succinyl-coa:3-ketoacid-coenzyme a transferase sub...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Acetate CoA-transferase. [EC: 2.8.3.8]
Acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.
  • The enzyme belongs to family I of CoA-transferases, which operate with a ping-pong kinetic mechanism.
  • The reaction takes place in two half-reactions and involves the formation of a CoA thioester intermediate with a glutamate residue.
  • Unlike EC 2.8.3.9, this enzyme exhibits maximal activity using acetate as the CoA acceptor.
  • Substrate range depends on the specific enzyme.
  • Typical substrates include butanoyl-CoA and pentanoyl-CoA.
 3422 A0A069XUQ8 A0A069XUQ8 A0A069XUQ8 A0A069XUQ8 A0A069XUQ8 A0A069XUQ8 A0A069XUQ8 A0A069XUQ8 A0A069XUQ8 A0A069XUQ8
(3412 more...)
3-oxoacid CoA-transferase. [EC: 2.8.3.5]
Succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA.
  • Acetoacetate or, more slowly, 3-oxopropanoate, 3-oxopentanoate, 3-oxo-4-methylpentanoate or 3-oxohexanoate can act as acceptor.
  • Malonyl-CoA can act instead of succinyl-CoA.
 132 A0A024R040 A0A024R040 A0A045HCS5 A0A045HCS5 A0A045HCS5 A0A045HCS5 A0A045HCS5 A0A045HCS5 A0A045HCS5 A0A045HCS5
(122 more...)
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