The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"DNA Methylphosphotriester Repair Domain
".
FunFam 1: DNA-3-methyladenine glycosylase 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
23 |
P06134 (/TAS)
P06134 (/TAS)
P06134 (/TAS)
P06134 (/TAS)
P06134 (/TAS)
P06134 (/TAS)
P06134 (/TAS)
P06134 (/TAS)
P06134 (/TAS)
P06134 (/TAS)
(13 more) |
Methylated-DNA-[protein]-cysteine S-methyltransferase activity GO:0003908
Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.
|
23 |
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
(13 more) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
23 |
P06134 (/IPI)
P06134 (/IPI)
P06134 (/IPI)
P06134 (/IPI)
P06134 (/IPI)
P06134 (/IPI)
P06134 (/IPI)
P06134 (/IPI)
P06134 (/IPI)
P06134 (/IPI)
(13 more) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
23 |
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
(13 more) |
Methylated-DNA-[protein]-cysteine S-methyltransferase activity GO:0003908
Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.
|
3 | A0A0F7RF29 (/ISS) A0A0F7RF29 (/ISS) A0A0F7RF29 (/ISS) |
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
1 | Q5LNA1 (/ISS) |
There are 10 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
DNA dealkylation involved in DNA repair GO:0006307
The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).
|
28 |
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
(18 more) |
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
|
23 |
P06134 (/IEP)
P06134 (/IEP)
P06134 (/IEP)
P06134 (/IEP)
P06134 (/IEP)
P06134 (/IEP)
P06134 (/IEP)
P06134 (/IEP)
P06134 (/IEP)
P06134 (/IEP)
(13 more) |
Peptidyl-cysteine methylation GO:0018125
The methylation of peptidyl-cysteine to form peptidyl-S-methyl-L-cysteine.
|
23 |
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
(13 more) |
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
23 |
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
(13 more) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
23 |
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
(13 more) |
DNA demethylation GO:0080111
The removal of a methyl group from one or more nucleotides within an DNA molecule.
|
23 |
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
P06134 (/IDA)
(13 more) |
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
|
9 | A0A0F7RF29 (/ISS) A0A0F7RF29 (/ISS) A0A0F7RF29 (/ISS) Q9KKT2 (/ISS) Q9KKT2 (/ISS) Q9KKT2 (/ISS) Q9KKT2 (/ISS) Q9KKT2 (/ISS) Q9KKT2 (/ISS) |
Response to nitrosative stress GO:0051409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.
|
5 | P9WJW3 (/IDA) P9WJW3 (/IDA) P9WJW3 (/IDA) P9WJW3 (/IDA) P9WJW3 (/IDA) |
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
4 | A0A0F7RF29 (/ISS) A0A0F7RF29 (/ISS) A0A0F7RF29 (/ISS) Q5LNA1 (/ISS) |
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
|
3 | A0A0F7RF29 (/ISS) A0A0F7RF29 (/ISS) A0A0F7RF29 (/ISS) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
|
5 | P9WJW3 (/HDA) P9WJW3 (/HDA) P9WJW3 (/HDA) P9WJW3 (/HDA) P9WJW3 (/HDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
5 | P9WJW3 (/HDA) P9WJW3 (/HDA) P9WJW3 (/HDA) P9WJW3 (/HDA) P9WJW3 (/HDA) |