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CATH Superfamily 3.30.870.30

MITD, C-terminal phospholipase D-like domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
MITD, C-terminal phospholipase D-like domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: MITD, C-terminal phospholipase D-like domain

Structural domains comprising this superfamily share the structure of the C-terminal phospholipase D-like domain of microtubule-interacting and trafficking-domain (MITD) containing proteins. Available structural data comes from MITD1, a previously uncharacterized ESCRT-III interacting protein. ESCRT is the acronym given to endosomal sorting complexes required for transport, which have a critical function in abscission, the final separation of the daughter cells during cytokinesis. Structural characterization of MITD1 reveal a dimeric structure, with a (MIT) domain at the N terminus and a unique, unanticipated phospholipase D-like (PLD) domain at the C terminus that binds membranes PMID:23045692.

GO Diversity

Unique GO annotations
11 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
689 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 8
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 2
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 4
Function
Unique EC:
Unique GO: 11
Taxonomy
Unique Species: 689
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