The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"RNA Cap, Translation Initiation Factor Eif4e
".
FunFam 3: Eukaryotic translation initiation factor 4E
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
8 | O04663 (/IPI) O04663 (/IPI) O23252 (/IPI) O23252 (/IPI) O23252 (/IPI) Q03389 (/IPI) Q03389 (/IPI) Q03389 (/IPI) |
|
RNA 7-methylguanosine cap binding GO:0000340
Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.
|
3 | O81481 (/RCA) O81482 (/RCA) O81482 (/RCA) |
|
Eukaryotic initiation factor 4G binding GO:0031370
Interacting selectively and non-covalently with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation.
|
3 | O81481 (/RCA) O81482 (/RCA) O81482 (/RCA) |
|
RNA 7-methylguanosine cap binding GO:0000340
Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II.
|
2 | O04663 (/TAS) O04663 (/TAS) |
|
Translation initiation factor activity GO:0003743
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
|
2 | O04663 (/TAS) O04663 (/TAS) |
There are 3 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
|
5 | O04663 (/IMP) O04663 (/IMP) O23252 (/IMP) O23252 (/IMP) O23252 (/IMP) |
|
Negative regulation of defense response to virus GO:0050687
Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication.
|
2 | O04663 (/IMP) O04663 (/IMP) |
|
Response to anoxia GO:0034059
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%.
|
1 | O81481 (/IDA) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | O04663 (/IDA) O04663 (/IDA) O23252 (/IDA) O23252 (/IDA) O23252 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
5 | O04663 (/IDA) O04663 (/IDA) O23252 (/IDA) O23252 (/IDA) O23252 (/IDA) |
|
MRNA cap binding complex GO:0005845
Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA.
|
5 | O04663 (/ISS) O04663 (/ISS) O23252 (/ISS) O23252 (/ISS) O23252 (/ISS) |
|
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
|
3 | O23252 (/IDA) O23252 (/IDA) O23252 (/IDA) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
3 | O23252 (/IDA) O23252 (/IDA) O23252 (/IDA) |
|
MRNA cap binding complex GO:0005845
Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA.
|
3 | O81481 (/RCA) O81482 (/RCA) O81482 (/RCA) |
|
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
3 | O23252 (/IDA) O23252 (/IDA) O23252 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | O04663 (/IDA) O04663 (/IDA) |
