The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"STAS domain
".
FunFam 3: Chloride anion exchanger
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 26 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Anion:anion antiporter activity GO:0015301
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).
|
7 | A0A0A7HG43 (/IDA) A0A2R8PVM0 (/IDA) P58735 (/IDA) P58735 (/IDA) Q7T2C4 (/IDA) Q7T2N6 (/IDA) Q9WVC8 (/IDA) |
|
Oxalate transmembrane transporter activity GO:0019531
Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals.
|
5 | A0A2R8PVM0 (/IDA) P58735 (/IDA) P58735 (/IDA) Q7T2C4 (/IDA) Q7T2N6 (/IDA) |
|
Chloride transmembrane transporter activity GO:0015108
Enables the transfer of chloride ions from one side of a membrane to the other.
|
4 | P40879 (/ISS) P45380 (/ISS) Q924C9 (/ISS) Q9H2B4 (/ISS) |
|
Secondary active sulfate transmembrane transporter activity GO:0008271
Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.
|
3 | A0A2R8PVM0 (/IDA) Q7T2C4 (/IDA) Q7T2N6 (/IDA) |
|
Sodium:bicarbonate symporter activity GO:0008510
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in).
|
3 | A9JTH4 (/IMP) B6DUH7 (/IMP) B6DUH8 (/IMP) |
|
Ion transmembrane transporter activity GO:0015075
Enables the transfer of an ion from one side of a membrane to the other.
|
3 | A0A2R8PVM0 (/IDA) Q7T2C4 (/IDA) Q7T2N6 (/IDA) |
|
Chloride transmembrane transporter activity GO:0015108
Enables the transfer of chloride ions from one side of a membrane to the other.
|
3 | P58735 (/IDA) P58735 (/IDA) Q9R154 (/IDA) |
|
Sulfate transmembrane transporter activity GO:0015116
Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other.
|
3 | P45380 (/IDA) P58735 (/IDA) P58735 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P40879 (/IPI) Q9WVC8 (/IPI) |
|
Bicarbonate transmembrane transporter activity GO:0015106
Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-.
|
2 | P40879 (/ISS) Q924C9 (/ISS) |
|
Sulfate transmembrane transporter activity GO:0015116
Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other.
|
2 | P58735 (/ISO) P58735 (/ISO) |
|
Anion:anion antiporter activity GO:0015301
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).
|
2 | P45380 (/ISS) Q9H2B4 (/ISS) |
|
Oxalate transmembrane transporter activity GO:0019531
Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals.
|
2 | P45380 (/ISS) Q9H2B4 (/ISS) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
1 | P40879 (/TAS) |
|
Transcription coregulator activity GO:0003712
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators.
|
1 | P40879 (/TAS) |
|
Transporter activity GO:0005215
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
|
1 | P40879 (/TAS) |
|
Anion transmembrane transporter activity GO:0008509
Enables the transfer of a negatively charged ion from one side of a membrane to the other.
|
1 | Q9R155 (/ISS) |
|
Bicarbonate transmembrane transporter activity GO:0015106
Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-.
|
1 | Q9WVC8 (/IMP) |
|
Chloride transmembrane transporter activity GO:0015108
Enables the transfer of chloride ions from one side of a membrane to the other.
|
1 | Q9WVC8 (/IMP) |
|
Chloride transmembrane transporter activity GO:0015108
Enables the transfer of chloride ions from one side of a membrane to the other.
|
1 | Q9R155 (/ISO) |
|
Chloride transmembrane transporter activity GO:0015108
Enables the transfer of chloride ions from one side of a membrane to the other.
|
1 | O43511 (/TAS) |
|
Iodide transmembrane transporter activity GO:0015111
Enables the transfer of iodide ions from one side of a membrane to the other.
|
1 | Q9R154 (/IDA) |
|
Iodide transmembrane transporter activity GO:0015111
Enables the transfer of iodide ions from one side of a membrane to the other.
|
1 | Q9R155 (/ISO) |
|
Iodide transmembrane transporter activity GO:0015111
Enables the transfer of iodide ions from one side of a membrane to the other.
|
1 | O43511 (/TAS) |
|
Sulfate transmembrane transporter activity GO:0015116
Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other.
|
1 | Q9H2B4 (/ISS) |
|
Sulfate transmembrane transporter activity GO:0015116
Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other.
|
1 | O43511 (/TAS) |
There are 38 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
6 | A0A0A7HG43 (/IDA) A0A2R8PVM0 (/IDA) P58735 (/IDA) P58735 (/IDA) Q7T2C4 (/IDA) Q7T2N6 (/IDA) |
|
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
6 | A9JTH4 (/IMP) B6DUH7 (/IMP) B6DUH8 (/IMP) C8XTB7 (/IMP) F1QGE0 (/IMP) Q1L977 (/IMP) |
|
Sulfate transport GO:0008272
The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
6 | A0A2R8PVM0 (/IDA) P45380 (/IDA) P58735 (/IDA) P58735 (/IDA) Q7T2C4 (/IDA) Q7T2N6 (/IDA) |
|
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
|
6 | A0A2R8RSH7 (/IDA) A9C3T3 (/IDA) B6DUH7 (/IDA) C8XTB7 (/IDA) F1QGE0 (/IDA) Q1L977 (/IDA) |
|
Anion homeostasis GO:0055081
Any process involved in the maintenance of an internal steady state of anions within an organism or cell.
|
6 | A0A2R8RSH7 (/IDA) A9C3T3 (/IDA) B6DUH7 (/IDA) C8XTB7 (/IDA) F1QGE0 (/IDA) Q1L977 (/IDA) |
|
Oxalate transport GO:0019532
The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals.
|
5 | A0A2R8PVM0 (/IDA) P58735 (/IDA) P58735 (/IDA) Q7T2C4 (/IDA) Q7T2N6 (/IDA) |
|
Ion transport GO:0006811
The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
3 | O43511 (/TAS) P40879 (/TAS) Q9H2B4 (/TAS) |
|
Regulation of membrane potential GO:0042391
Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
|
3 | A0A2R8PVM0 (/IDA) Q7T2C4 (/IDA) Q7T2N6 (/IDA) |
|
Regulation of pH GO:0006885
Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell.
|
2 | O43511 (/ISS) Q9R154 (/ISS) |
|
Sulfate transport GO:0008272
The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | P58735 (/ISO) P58735 (/ISO) |
|
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
|
2 | O43511 (/ISS) Q9R154 (/ISS) |
|
Sperm capacitation GO:0048240
A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium.
|
2 | P40879 (/ISS) Q924C9 (/ISS) |
|
Intracellular pH elevation GO:0051454
Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion.
|
2 | P40879 (/ISS) Q924C9 (/ISS) |
|
Membrane hyperpolarization GO:0060081
The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential.
|
2 | P40879 (/ISS) Q924C9 (/ISS) |
|
Cellular response to cAMP GO:0071320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
|
2 | P40879 (/ISS) Q924C9 (/ISS) |
|
Anion transport GO:0006820
The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | P40879 (/TAS) |
|
Chloride transport GO:0006821
The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q9H2B4 (/ISS) |
|
Regulation of pH GO:0006885
Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell.
|
1 | Q9R155 (/IMP) |
|
Excretion GO:0007588
The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.
|
1 | P40879 (/TAS) |
|
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
|
1 | E7F9I7 (/IMP) |
|
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
|
1 | O43511 (/TAS) |
|
Sulfate transport GO:0008272
The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q9H2B4 (/ISS) |
|
Sulfate transport GO:0008272
The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | O43511 (/TAS) |
|
Animal organ morphogenesis GO:0009887
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
|
1 | Q9R155 (/ISS) |
|
Inorganic anion transport GO:0015698
The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage.
|
1 | Q9R154 (/IDA) |
|
Inorganic anion transport GO:0015698
The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage.
|
1 | Q9R155 (/ISO) |
|
Inorganic anion transport GO:0015698
The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage.
|
1 | O43511 (/TAS) |
|
Oxalate transport GO:0019532
The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals.
|
1 | Q9H2B4 (/ISS) |
|
Otolith morphogenesis GO:0032474
The process in which the anatomical structures of an otolith are generated and organized.
|
1 | E7F9I7 (/IMP) |
|
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
|
1 | Q9R155 (/IMP) |
|
Swimming behavior GO:0036269
The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water.
|
1 | E7F9I7 (/IMP) |
|
Sperm capacitation GO:0048240
A process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium.
|
1 | Q9WVC8 (/IMP) |
|
Neuromast development GO:0048884
The process whose specific outcome is the progression of the neuromast over time, from its formation to the mature structure. The neuromast is the sensory organ of the lateral line and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromasts are located superficially on the epithelium or in lateral line canals.
|
1 | E7F9I7 (/IMP) |
|
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process GO:0050428
The chemical reactions and pathways resulting in the formation of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems.
|
1 | Q9H2B4 (/TAS) |
|
Intracellular pH elevation GO:0051454
Any process that increases the internal pH of a cell, measured by the concentration of the hydrogen ion.
|
1 | Q9WVC8 (/IMP) |
|
Membrane hyperpolarization GO:0060081
The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential.
|
1 | Q9WVC8 (/IMP) |
|
Auditory receptor cell development GO:0060117
The process whose specific outcome is the progression of an auditory receptor cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
|
1 | E7F9I7 (/IMP) |
|
Cellular response to cAMP GO:0071320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
|
1 | Q9WVC8 (/IDA) |
There are 20 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
4 | O43511 (/IDA) Q924C9 (/IDA) Q9R154 (/IDA) Q9R155 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | A0A2R8PVM0 (/IDA) Q7T2C4 (/IDA) Q7T2N6 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | A0A2R8PVM0 (/IDA) Q7T2C4 (/IDA) Q7T2N6 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | O43511 (/TAS) P40879 (/TAS) Q9H2B4 (/TAS) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | A0A2R8PVM0 (/ISS) Q7T2C4 (/ISS) Q7T2N6 (/ISS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | Q9R155 (/IDA) Q9WVC8 (/IDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | P40879 (/ISS) Q924C9 (/ISS) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | O43511 (/TAS) Q9H2B4 (/TAS) |
|
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
2 | Q9R155 (/ISO) Q9WVC8 (/ISO) |
|
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
2 | O43511 (/ISS) Q9R154 (/ISS) |
|
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
|
2 | Q924C9 (/IDA) Q9R155 (/IDA) |
|
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
|
2 | O43511 (/ISS) Q9R154 (/ISS) |
|
Sperm midpiece GO:0097225
The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece.
|
2 | P40879 (/ISS) Q924C9 (/ISS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q9WVC8 (/ISS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | P40879 (/TAS) |
|
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
|
1 | Q9WVC8 (/ISO) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | O43511 (/HDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | O43511 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q9R155 (/ISO) |
|
Sperm midpiece GO:0097225
The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece.
|
1 | Q9WVC8 (/IDA) |
