The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Elongation Factor G (Translational Gtpase), domain 3
".
FunFam 2: Translation elongation factor 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 30 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
25 |
O94316 (/IPI)
P13639 (/IPI)
P13639 (/IPI)
P13639 (/IPI)
P13639 (/IPI)
P13639 (/IPI)
P13639 (/IPI)
P13639 (/IPI)
P32324 (/IPI)
P32324 (/IPI)
(15 more) |
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
|
18 |
P32324 (/IDA)
P32324 (/IDA)
P32324 (/IDA)
P32324 (/IDA)
P32324 (/IDA)
P32324 (/IDA)
P32324 (/IDA)
P32324 (/IDA)
P32324 (/IDA)
P32324 (/IDA)
(8 more) |
Translation elongation factor activity GO:0003746
Functions in chain elongation during polypeptide synthesis at the ribosome.
|
12 |
O14460 (/TAS)
P05197 (/TAS)
P32324 (/TAS)
P32324 (/TAS)
P32324 (/TAS)
P32324 (/TAS)
P32324 (/TAS)
P32324 (/TAS)
P32324 (/TAS)
P32324 (/TAS)
(2 more) |
Ribosome binding GO:0043022
Interacting selectively and non-covalently with any part of a ribosome.
|
11 |
P05197 (/IDA)
P32324 (/IDA)
P32324 (/IDA)
P32324 (/IDA)
P32324 (/IDA)
P32324 (/IDA)
P32324 (/IDA)
P32324 (/IDA)
P32324 (/IDA)
P32324 (/IDA)
(1 more) |
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
10 | P13639 (/HDA) P13639 (/HDA) P13639 (/HDA) P13639 (/HDA) P13639 (/HDA) P13639 (/HDA) P13639 (/HDA) Q15029 (/HDA) Q15029 (/HDA) Q15029 (/HDA) |
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
7 | O14460 (/ISM) O74945 (/ISM) Q381P2 (/ISM) Q38BE4 (/ISM) Q38BE4 (/ISM) Q38BE4 (/ISM) Q38BE4 (/ISM) |
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
7 | P13639 (/IPI) P13639 (/IPI) P13639 (/IPI) P13639 (/IPI) P13639 (/IPI) P13639 (/IPI) P13639 (/IPI) |
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
7 | P13639 (/HDA) P13639 (/HDA) P13639 (/HDA) P13639 (/HDA) P13639 (/HDA) P13639 (/HDA) P13639 (/HDA) |
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
|
6 | Q38BE4 (/IDA) Q38BE4 (/IDA) Q38BE4 (/IDA) Q38BE4 (/IDA) Q9ASR1 (/IDA) Q9ASR1 (/IDA) |
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
|
6 | Q8C0D5 (/ISS) Q8IJZ9 (/ISS) Q8IJZ9 (/ISS) Q8IJZ9 (/ISS) Q8IJZ9 (/ISS) Q8IJZ9 (/ISS) |
Showing 1 to 10 of 30 entries
There are 66 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
|
10 | A4FUD3 (/ISS) O08810 (/ISS) O08810 (/ISS) Q5F3X4 (/ISS) Q5R6E0 (/ISS) Q8IJZ9 (/ISS) Q8IJZ9 (/ISS) Q8IJZ9 (/ISS) Q8IJZ9 (/ISS) Q8IJZ9 (/ISS) |
Translational elongation GO:0006414
The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.
|
10 | P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) |
Positive regulation of translational elongation GO:0045901
Any process that activates or increases the frequency, rate or extent of translational elongation.
|
10 | P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) |
Maintenance of translational fidelity GO:1990145
Suppression of the occurrence of translational errors, such as codon-anticodon mis-paring, during the process of translation of a protein using an mRNA template.
|
10 | P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) P32324 (/IMP) |
Translational elongation GO:0006414
The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.
|
8 | P05197 (/TAS) P13639 (/TAS) P13639 (/TAS) P13639 (/TAS) P13639 (/TAS) P13639 (/TAS) P13639 (/TAS) P13639 (/TAS) |
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
|
7 | P13639 (/TAS) P13639 (/TAS) P13639 (/TAS) P13639 (/TAS) P13639 (/TAS) P13639 (/TAS) P13639 (/TAS) |
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
7 | P13639 (/IMP) P13639 (/IMP) P13639 (/IMP) P13639 (/IMP) P13639 (/IMP) P13639 (/IMP) P13639 (/IMP) |
RNA splicing, via transesterification reactions GO:0000375
Splicing of RNA via a series of two transesterification reactions.
|
5 | Q8IJZ9 (/ISS) Q8IJZ9 (/ISS) Q8IJZ9 (/ISS) Q8IJZ9 (/ISS) Q8IJZ9 (/ISS) |
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
|
5 | A8WFS1 (/IMP) E7FGW2 (/IMP) E9QH15 (/IMP) F1Q6N0 (/IMP) Q803Q6 (/IMP) |
Translation GO:0006412
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
|
5 | Q381P2 (/ISM) Q38BE4 (/ISM) Q38BE4 (/ISM) Q38BE4 (/ISM) Q38BE4 (/ISM) |
Showing 1 to 10 of 66 entries
There are 74 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
22 |
P05197 (/IDA)
P13639 (/IDA)
P13639 (/IDA)
P13639 (/IDA)
P13639 (/IDA)
P13639 (/IDA)
P13639 (/IDA)
P13639 (/IDA)
P15112 (/IDA)
P53893 (/IDA)
(12 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
18 |
O14460 (/HDA)
O74945 (/HDA)
O94316 (/HDA)
P32324 (/HDA)
P32324 (/HDA)
P32324 (/HDA)
P32324 (/HDA)
P32324 (/HDA)
P32324 (/HDA)
P32324 (/HDA)
(8 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
17 |
P13639 (/TAS)
P13639 (/TAS)
P13639 (/TAS)
P13639 (/TAS)
P13639 (/TAS)
P13639 (/TAS)
P13639 (/TAS)
P32324 (/TAS)
P32324 (/TAS)
P32324 (/TAS)
(7 more) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
14 |
A0SXL6 (/ISS)
A0SXL6 (/ISS)
A0SXL6 (/ISS)
P09445 (/ISS)
Q3SYU2 (/ISS)
Q3SYU2 (/ISS)
Q5R8Z3 (/ISS)
Q5R8Z3 (/ISS)
Q5R8Z3 (/ISS)
Q5R8Z3 (/ISS)
(4 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
14 |
F4J2T9 (/IDA)
P05197 (/IDA)
P13639 (/IDA)
P13639 (/IDA)
P13639 (/IDA)
P13639 (/IDA)
P13639 (/IDA)
P13639 (/IDA)
P13639 (/IDA)
Q15029 (/IDA)
(4 more) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
11 |
P13639 (/IDA)
P13639 (/IDA)
P13639 (/IDA)
P13639 (/IDA)
P13639 (/IDA)
P13639 (/IDA)
P13639 (/IDA)
Q5A0M4 (/IDA)
Q9ASR1 (/IDA)
Q9ASR1 (/IDA)
(1 more) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
10 | P13639 (/HDA) P13639 (/HDA) P13639 (/HDA) P13639 (/HDA) P13639 (/HDA) P13639 (/HDA) P13639 (/HDA) Q15029 (/HDA) Q15029 (/HDA) Q15029 (/HDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
8 | O94316 (/HDA) P13639 (/HDA) P13639 (/HDA) P13639 (/HDA) P13639 (/HDA) P13639 (/HDA) P13639 (/HDA) P13639 (/HDA) |
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
|
8 | P05197 (/IDA) P13639 (/IDA) P13639 (/IDA) P13639 (/IDA) P13639 (/IDA) P13639 (/IDA) P13639 (/IDA) P13639 (/IDA) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
7 | P13639 (/TAS) P13639 (/TAS) P13639 (/TAS) P13639 (/TAS) P13639 (/TAS) P13639 (/TAS) P13639 (/TAS) |
Showing 1 to 10 of 74 entries