The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Flavivirus RNA-directed RNA polymerase, thumb domain
".
FunFam 1: Genome polyprotein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
MRNA (nucleoside-2'-O-)-methyltransferase activity GO:0004483
Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine.
|
4 | P06935 (/IDA) Q9Q6P4 (/IDA) Q9Q6P4 (/IDA) Q9Q6P4 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | A0A142I5B9 (/IPI) A0A142I5B9 (/IPI) P06935 (/IPI) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | P06935 (/IMP) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | P06935 (/IMP) |
|
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
|
1 | P06935 (/IDA) |
|
RNA strand annealing activity GO:0033592
Facilitates the base-pairing of complementary single-stranded RNA.
|
1 | P06935 (/IMP) |
|
DNA/DNA annealing activity GO:1990814
A nucleic acid binding activity that brings together complementary sequences of ssDNA so that they pair by hydrogen bonds to form a double-stranded DNA.
|
1 | P06935 (/IMP) |
There are 9 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Suppression by virus of host apoptotic process GO:0019050
Any viral process that inhibits apoptosis of infected host cells, facilitating prolonged cell survival during viral replication.
|
1 | P06935 (/IDA) |
|
Viral genome replication GO:0019079
Any process involved directly in viral genome replication, including viral nucleotide metabolism.
|
1 | G4XII4 (/IDA) |
|
Viral genome replication GO:0019079
Any process involved directly in viral genome replication, including viral nucleotide metabolism.
|
1 | G4XII4 (/IMP) |
|
Evasion or tolerance by virus of host immune response GO:0030683
Any process, either active or passive, by which a virus avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
1 | Q2YHF0 (/IMP) |
|
Suppression by virus of host type I interferon-mediated signaling pathway GO:0039502
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
|
1 | Q01299 (/IDA) |
|
Suppression by virus of host STAT1 activity GO:0039563
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity. STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes.
|
1 | Q01299 (/IDA) |
|
RNA stabilization GO:0043489
Prevention of degradation of RNA molecules.
|
1 | P06935 (/IMP) |
|
Positive regulation of viral genome replication GO:0045070
Any process that activates or increases the frequency, rate or extent of viral genome replication.
|
1 | P06935 (/IMP) |
|
RNA 5'-cap (guanine-N7)-methylation GO:0106005
The process whereby a guanine in 5-cap is methylated at the N7 position of guanine.
|
1 | P06935 (/IDA) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Viral envelope GO:0019031
The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins.
|
1 | P03314 (/IMP) |
|
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
|
1 | P06935 (/IMP) |
|
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
|
1 | P06935 (/IMP) |
