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CATH Superfamily 3.30.70.270

Reverse transcriptase/Diguanylate cyclase domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1POL polyproteinSC:2Genome polyproteinSC:3Diguanylate cyclase YdeHSensor domain-containing diguanylate cyclaseProtein FimXDiguanylate cyclase TpbBDNA repair protein REV1Diguanylate cyclase/phosphodiesteraseResponse regulator PleDSC:4DNA polymerase IVDNA repair protein REV1Polymerase (DNA directed) iotaDNA polymerase etaSC:5Transposon Ty3-G Gag-Pol polyproteinSC:6Transposon Ty3-G Gag-Pol polyproteinGag-Pol polyproteinDiguanylate cyclase domain proteinPol polyproteinGag-Pol polyproteinMembrane-associated phosphodiesteraseGenome polyproteinProtein PDNA repair protein REV1DNA polymerase kappaDNA polymerase V subunitDNA polymerase kappa subunitGenome polyproteinPredicted diguanylate cyclaseDiguanylate cyclase domain proteinDNA repair protein REV1Transposon Tf2-6 polyprotein-like ProteinGenome polyproteinPolPredicted diguanylate cyclaseRetrovirus-related Pol polyprotein LINE-1RNase E specificity factor CsrDDiguanylate cyclase domain proteinDNA polymerase etaGenome polyproteinGenome polyproteinCyclic di-GMP phosphodiesterase GmrProbable diguanylate cyclase YeaPDiguanylate cyclase domain proteinDiguanylate cyclase domain-containing proteinSensory box/GGDEF family proteinDiguanylate cyclase domain proteinPaternally expressed 10DNA repair protein REV1Uncharacterized proteinDiguanylate cyclase (GGDEF) domain proteinDiguanylate cyclase (GGDEF)-like proteinTransposon Tf2-7 polyproteinGenome polyproteinDiguanylate cyclase (GGDEF) domain proteinGag-Pol polyproteinDNA repair proteinGenome polyproteinDNA repair protein REV1DNA polymerase IVPutative DNA polymerase kappaSensor domain-containing diguanylate cyclaseSister chromatid cohesion protein Eso1DNA polymerase eta isoform X2Protein PDiguanylate cyclase (GGDEF) domain-containing proteinDiguanylate cyclaseDNA polymerase IVUncharacterized proteinZinc knuckle domaincontaining proteinDiguanylate cyclaseGenome polyproteinEndogenous retrovirus group K member 6 Pol proteinDNA polymerase iota, putativePutative diguanylate cyclaseProbable diguanylate cyclase DgcEDNA polymerase IVSensor domain-containing diguanylate cyclaseDNA polymerase IVDiguanylate cyclase (GGDEF) domain proteinDiguanylate cyclase DosCBiofilm formation regulator HmsPDiguanylate cyclaseDNA polymerase IVDiguanylate cyclase response regulatorDiguanylate cyclaseBifunctional diguanylate cyclase/phosphodiesteraseUncharacterized proteinDNA polymerase etaREV1, polymerase (DNA directed)Endogenous retrovirus group K member 10 Pol proteinYALI0E34980pGGDEF family proteinBiofilm architecture maintenance protein mbaAGenome polyproteinSensor domain-containing diguanylate cyclaseGGDEF family proteinBifunctional diguanylate cyclase/phosphodiesteraseUncharacterized proteinRelated to DNA polymerase etaDiguanylate cyclaseDNA polymerase IVUncharacterized proteinDNA-directed polymerase kappa, putative (AFU_orthologue AFUA_7G01270)Putative DNA polymerase etaSensory box/GGDEF family proteinHeme-regulated cyclic AMP phosphodiesterase (Direct oxygen sensor protein)PolyproteinGGDEF family proteinGGDEF domain-containing proteinGGDEF family proteinGGDEF family proteinDNApol-iota, isoform AGenome polyproteinUncharacterized proteinDNA polymerase etaSensory box/GGDEF family proteinPolyprotein of retroviral origin, putativeSensory box/GGDEF family proteinGGDEF family proteinGGDEF family proteinGGDEF family proteinDiguanylate cyclaseAGAP001404-PAUncharacterized proteinDeoxycytidyl transferase, putativeDNA repair protein REV1Uncharacterized proteinGGDEF family proteinCRISPR-associated protein cas10/csm1, subtype III-a/mtubeTranscriptional regulator CdgAGGDEF family proteinRelated to DNA repair protein MUS-42Diguanylate cyclaseDiguanylate cyclase (GGDEF) domain proteinDNA polymerase kappaUncharacterized proteinDiguanylate cyclase or phosphodiesterasePol polyproteinPro-Pol polyproteinPol polyproteinDiguanylate cyclase-related enzymeDNA polymerase eta subunitUncharacterized proteinUncharacterized proteinUncharacterized proteinDNA polymerase Y family proteinPutative signal protein with GGDEF domainDNA polymerase etaPolymerase (DNA directed) kappaUncharacterized proteinUncharacterized proteinPol polyproteinDNA damage repair protein, putativePutative diguanylate cyclase YcdTGGDEF family proteinTransposon Tf2-9 polyprotein-like ProteinUncharacterized proteinRetrovirus-related Pol polyprotein from transposon gypsy-like ProteinResponse regulator ActAPutative diguanylate cyclaseDiguanylate cyclase/phosphodiesterase (GGDEF & EAL domain) with PAS/PAC sensor(S)Cyclic di-GMP phosphodiesterase GmrDNA polymerase kappaPAS/PAC sensor-containing diguanylate cyclase/phosphodiesteraseDiguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S)Bifunctional diguanylate cyclase/phosphodiesteraseUncharacterized protein
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FunFam 83: Genome polyprotein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 7 B1PVV8 (/IPI) F2X8A1 (/IPI) P19711 (/IPI) P19712 (/IPI) Q5U8X5 (/IPI) Q68871 (/IPI) Q9YS30 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
 1 P19711 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
 1 P19711 (/IDA)
RNA strand annealing activity GO:0033592
Facilitates the base-pairing of complementary single-stranded RNA.
 1 P19711 (/IDA)
DNA/DNA annealing activity GO:1990814
A nucleic acid binding activity that brings together complementary sequences of ssDNA so that they pair by hydrogen bonds to form a double-stranded DNA.
 1 P19711 (/IDA)
Showing 1 to 5 of 5 entries

There are 1 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
RNA stabilization GO:0043489
Prevention of degradation of RNA molecules.
 1 P19711 (/IDA)
Showing 1 to 1 of 1 entries

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
 1 P19711 (/IDA)
Host cell cytoplasmic vesicle GO:0044161
A vesicle formed of membrane or protein, found in the cytoplasm of a host cell.
 1 P19711 (/IDA)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
 1 P19711 (/IDA)
Showing 1 to 3 of 3 entries
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