The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Structural maintenance of chromosomes 3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
42 O42649 (/IPI) O93309 (/IPI) Q9CW03 (/IPI) Q9CW03 (/IPI) Q9UQE7 (/IPI) Q9UQE7 (/IPI) Q9UQE7 (/IPI) Q9UQE7 (/IPI) Q9UQE7 (/IPI) Q9UQE7 (/IPI)
(32 more)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
38 Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS)
(28 more)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
38 Q9UQE7 (/IPI) Q9UQE7 (/IPI) Q9UQE7 (/IPI) Q9UQE7 (/IPI) Q9UQE7 (/IPI) Q9UQE7 (/IPI) Q9UQE7 (/IPI) Q9UQE7 (/IPI) Q9UQE7 (/IPI) Q9UQE7 (/IPI)
(28 more)
Beta-tubulin binding GO:0048487
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.
38 Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA)
(28 more)
Dynein complex binding GO:0070840
Interacting selectively and non-covalently with a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.
38 Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA)
(28 more)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 A0A0R4ITA5 (/IPI) B2GRT6 (/IPI) Q1LVV8 (/IPI) Q803N2 (/IPI)
Dynein complex binding GO:0070840
Interacting selectively and non-covalently with a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.
4 O97594 (/ISS) P97690 (/ISS) Q9CW03 (/ISS) Q9CW03 (/ISS)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
2 Q9CW03 (/IDA) Q9CW03 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
2 Q24098 (/ISS) Q9VXE9 (/ISS)
Mediator complex binding GO:0036033
Interacting selectively and non-covalently with a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
2 Q9CW03 (/IDA) Q9CW03 (/IDA)
Showing 1 to 10 of 16 entries

There are 32 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Regulation of DNA replication GO:0006275
Any process that modulates the frequency, rate or extent of DNA replication.
43 O93309 (/ISS) O97594 (/ISS) P97690 (/ISS) Q5R4K5 (/ISS) Q5R4K5 (/ISS) Q5R4K5 (/ISS) Q5R4K5 (/ISS) Q5R4K5 (/ISS) Q5R4K5 (/ISS) Q5R4K5 (/ISS)
(33 more)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
38 Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS)
(28 more)
Regulation of DNA replication GO:0006275
Any process that modulates the frequency, rate or extent of DNA replication.
38 Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP)
(28 more)
Sister chromatid cohesion GO:0007062
The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.
38 Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP)
(28 more)
Sister chromatid cohesion GO:0007062
The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other.
38 Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS)
(28 more)
Negative regulation of DNA endoreduplication GO:0032876
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication.
38 Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP)
(28 more)
Positive regulation by host of viral release from host cell GO:0044791
A process in which a host organism activates or increases the frequency, rate or extent of the release of a virus with which it is infected, from its cells.
38 Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA)
(28 more)
Meiotic cell cycle GO:0051321
Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
38 Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA)
(28 more)
Interaction with symbiont GO:0051702
An interaction between two organisms living together in more or less intimate association. The term symbiont is used for the smaller (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism.
38 Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA)
(28 more)
Regulation of mitotic spindle assembly GO:1901673
Any process that modulates the frequency, rate or extent of mitotic spindle assembly.
38 Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP) Q9UQE7 (/IMP)
(28 more)
Showing 1 to 10 of 32 entries

There are 34 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
43 O93309 (/ISS) O97594 (/ISS) P97690 (/ISS) Q5R4K5 (/ISS) Q5R4K5 (/ISS) Q5R4K5 (/ISS) Q5R4K5 (/ISS) Q5R4K5 (/ISS) Q5R4K5 (/ISS) Q5R4K5 (/ISS)
(33 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
43 Q8AWB8 (/TAS) Q8AWB8 (/TAS) Q8AWB8 (/TAS) Q9CW03 (/TAS) Q9CW03 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS)
(33 more)
Cohesin complex GO:0008278
A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).
43 O42649 (/IDA) Q24098 (/IDA) Q9CW03 (/IDA) Q9CW03 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA)
(33 more)
Meiotic cohesin complex GO:0030893
A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex.
43 O93309 (/ISS) O97594 (/ISS) P97690 (/ISS) Q5R4K5 (/ISS) Q5R4K5 (/ISS) Q5R4K5 (/ISS) Q5R4K5 (/ISS) Q5R4K5 (/ISS) Q5R4K5 (/ISS) Q5R4K5 (/ISS)
(33 more)
Cohesin complex GO:0008278
A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).
40 Q24098 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS) Q9UQE7 (/NAS)
(30 more)
Meiotic cohesin complex GO:0030893
A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex.
40 Q9CW03 (/IDA) Q9CW03 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA)
(30 more)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
39 P97690 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS)
(29 more)
Chromosome, centromeric region GO:0000775
The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
38 Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS)
(28 more)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
38 Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA) Q9UQE7 (/IDA)
(28 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
38 Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS) Q9UQE7 (/TAS)
(28 more)
Showing 1 to 10 of 34 entries
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