The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Multidrug efflux transporter AcrB pore domain
".
FunFam 1: Efflux pump membrane transporter
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
118 |
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
(108 more) |
|
Xenobiotic transmembrane transporter activity GO:0042910
Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
|
113 |
P24177 (/IMP)
P24177 (/IMP)
P24177 (/IMP)
P24177 (/IMP)
P24177 (/IMP)
P24177 (/IMP)
P24177 (/IMP)
P24177 (/IMP)
P24177 (/IMP)
P24177 (/IMP)
(103 more) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
84 |
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
(74 more) |
|
Xenobiotic transmembrane transporter activity GO:0042910
Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
|
35 |
Q608A0 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
(25 more) |
|
Xenobiotic transmembrane transporter activity GO:0042910
Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
|
22 |
G3XCW2 (/IDA)
G3XCW2 (/IDA)
Q9HVI9 (/IDA)
Q9HW27 (/IDA)
Q9HW27 (/IDA)
Q9HW27 (/IDA)
Q9HWH4 (/IDA)
Q9HWH4 (/IDA)
Q9HWH4 (/IDA)
Q9HWH4 (/IDA)
(12 more) |
|
Transporter activity GO:0005215
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.
|
12 |
Q47VA5 (/ISS)
Q9KR85 (/ISS)
Q9KR85 (/ISS)
Q9KR85 (/ISS)
Q9KR85 (/ISS)
Q9KR85 (/ISS)
Q9KR85 (/ISS)
Q9KRG9 (/ISS)
Q9KRG9 (/ISS)
Q9KRG9 (/ISS)
(2 more) |
|
Xenobiotic transmembrane transporter activity GO:0042910
Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
|
6 | P52002 (/IGC) P52002 (/IGC) P52002 (/IGC) P52002 (/IGC) P52002 (/IGC) P52002 (/IGC) |
There are 9 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Drug transmembrane transport GO:0006855
The process in which a drug is transported across a membrane.
|
134 |
P24177 (/IMP)
P24177 (/IMP)
P24177 (/IMP)
P24177 (/IMP)
P24177 (/IMP)
P24177 (/IMP)
P24177 (/IMP)
P24177 (/IMP)
P24177 (/IMP)
P24177 (/IMP)
(124 more) |
|
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
84 |
P31224 (/IMP)
P31224 (/IMP)
P31224 (/IMP)
P31224 (/IMP)
P31224 (/IMP)
P31224 (/IMP)
P31224 (/IMP)
P31224 (/IMP)
P31224 (/IMP)
P31224 (/IMP)
(74 more) |
|
Drug transmembrane transport GO:0006855
The process in which a drug is transported across a membrane.
|
34 |
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
(24 more) |
|
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
32 |
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
Q880Q4 (/ISS)
(22 more) |
|
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
29 |
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
(19 more) |
|
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
5 | G3XCW2 (/EXP) G3XCW2 (/EXP) Q9HVI9 (/EXP) Q9RG59 (/EXP) Q9RG59 (/EXP) |
|
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
|
4 | G3XCW2 (/EXP) G3XCW2 (/EXP) Q9RG59 (/EXP) Q9RG59 (/EXP) |
|
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
|
4 | G3XCW2 (/IMP) G3XCW2 (/IMP) Q9RG59 (/IMP) Q9RG59 (/IMP) |
|
Drug transport GO:0015893
The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | Q608A0 (/ISS) |
There are 6 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
169 |
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
(159 more) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
112 |
P31224 (/IDA)
P31224 (/IDA)
P31224 (/IDA)
P31224 (/IDA)
P31224 (/IDA)
P31224 (/IDA)
P31224 (/IDA)
P31224 (/IDA)
P31224 (/IDA)
P31224 (/IDA)
(102 more) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
105 |
P31224 (/HDA)
P31224 (/HDA)
P31224 (/HDA)
P31224 (/HDA)
P31224 (/HDA)
P31224 (/HDA)
P31224 (/HDA)
P31224 (/HDA)
P31224 (/HDA)
P31224 (/HDA)
(95 more) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
84 |
P31224 (/RCA)
P31224 (/RCA)
P31224 (/RCA)
P31224 (/RCA)
P31224 (/RCA)
P31224 (/RCA)
P31224 (/RCA)
P31224 (/RCA)
P31224 (/RCA)
P31224 (/RCA)
(74 more) |
|
Efflux pump complex GO:1990281
A protein complex that is capable of efflux transmembrane transporter activity.
|
84 |
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
P31224 (/IPI)
(74 more) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
29 |
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
P24177 (/IDA)
(19 more) |
