CATH Superfamily 3.30.70.1390
ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2
The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2
".
FunFam 3: Malignant fibrous histiocytoma-amplified sequence ...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q9Y4C4 (/IPI) |
|
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
1 | Q9Y4C4 (/IDA) |
|
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
1 | Q3V1N1 (/ISO) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
1 | Q9Y4C4 (/IPI) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
1 | Q3V1N1 (/ISO) |
|
Protein phosphatase 2A binding GO:0051721
Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.
|
1 | Q9Y4C4 (/IDA) |
|
Protein phosphatase 2A binding GO:0051721
Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.
|
1 | Q3V1N1 (/ISO) |
|
Protein phosphatase 2A binding GO:0051721
Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.
|
1 | Q3V1N1 (/ISS) |
There are 44 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
2 | Q3V1N1 (/IMP) Q9Y4C4 (/IMP) |
|
Negative regulation of toll-like receptor 2 signaling pathway GO:0034136
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway.
|
2 | Q3V1N1 (/IMP) Q9Y4C4 (/IMP) |
|
Positive regulation of toll-like receptor 2 signaling pathway GO:0034137
Any process that activates or increases the frequency, rate, or extent of toll-like receptor 2 signaling pathway.
|
2 | Q3V1N1 (/IMP) Q9Y4C4 (/IMP) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
2 | Q3V1N1 (/IMP) Q9Y4C4 (/IMP) |
|
Defense response GO:0006952
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
|
1 | Q3V1N1 (/IMP) |
|
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
1 | Q3V1N1 (/ISO) |
|
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
1 | Q3V1N1 (/ISS) |
|
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
|
1 | Q9Y4C4 (/IMP) |
|
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
|
1 | Q3V1N1 (/ISO) |
|
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
|
1 | Q3V1N1 (/ISS) |
|
Regulation of toll-like receptor signaling pathway GO:0034121
Any process that modulates the frequency, rate, or extent of toll-like receptor signaling pathway.
|
1 | Q3V1N1 (/IMP) |
|
Negative regulation of toll-like receptor 2 signaling pathway GO:0034136
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway.
|
1 | Q3V1N1 (/ISO) |
|
Negative regulation of toll-like receptor 2 signaling pathway GO:0034136
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway.
|
1 | Q3V1N1 (/ISS) |
|
Positive regulation of toll-like receptor 2 signaling pathway GO:0034137
Any process that activates or increases the frequency, rate, or extent of toll-like receptor 2 signaling pathway.
|
1 | Q3V1N1 (/ISO) |
|
Positive regulation of toll-like receptor 2 signaling pathway GO:0034137
Any process that activates or increases the frequency, rate, or extent of toll-like receptor 2 signaling pathway.
|
1 | Q3V1N1 (/ISS) |
|
Negative regulation of toll-like receptor 4 signaling pathway GO:0034144
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway.
|
1 | Q9Y4C4 (/IMP) |
|
Negative regulation of toll-like receptor 4 signaling pathway GO:0034144
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway.
|
1 | Q3V1N1 (/ISO) |
|
Negative regulation of toll-like receptor 4 signaling pathway GO:0034144
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway.
|
1 | Q3V1N1 (/ISS) |
|
Negative regulation of protein dephosphorylation GO:0035308
Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein.
|
1 | Q9Y4C4 (/IMP) |
|
Negative regulation of protein dephosphorylation GO:0035308
Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein.
|
1 | Q3V1N1 (/ISO) |
|
Negative regulation of protein dephosphorylation GO:0035308
Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein.
|
1 | Q3V1N1 (/ISS) |
|
Regulation of macrophage activation GO:0043030
Any process that modulates the frequency or rate of macrophage activation.
|
1 | Q9Y4C4 (/IMP) |
|
Regulation of macrophage activation GO:0043030
Any process that modulates the frequency or rate of macrophage activation.
|
1 | Q3V1N1 (/ISO) |
|
Regulation of macrophage activation GO:0043030
Any process that modulates the frequency or rate of macrophage activation.
|
1 | Q3V1N1 (/ISS) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
1 | Q3V1N1 (/ISO) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
1 | Q3V1N1 (/ISS) |
|
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
1 | Q9Y4C4 (/IMP) |
|
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
1 | Q3V1N1 (/ISO) |
|
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
1 | Q3V1N1 (/ISS) |
|
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
|
1 | Q9Y4C4 (/IMP) |
|
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
|
1 | Q3V1N1 (/ISO) |
|
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
|
1 | Q3V1N1 (/ISS) |
|
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
1 | Q9Y4C4 (/IMP) |
|
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
1 | Q3V1N1 (/ISO) |
|
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
1 | Q3V1N1 (/ISS) |
|
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | Q9Y4C4 (/IMP) |
|
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | Q3V1N1 (/ISO) |
|
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | Q3V1N1 (/ISS) |
|
Negative regulation of protein localization to nucleus GO:1900181
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus.
|
1 | Q9Y4C4 (/IMP) |
|
Negative regulation of protein localization to nucleus GO:1900181
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus.
|
1 | Q3V1N1 (/ISO) |
|
Negative regulation of protein localization to nucleus GO:1900181
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus.
|
1 | Q3V1N1 (/ISS) |
|
Positive regulation of p38MAPK cascade GO:1900745
Any process that activates or increases the frequency, rate or extent of p38MAPK cascade.
|
1 | Q9Y4C4 (/IMP) |
|
Positive regulation of p38MAPK cascade GO:1900745
Any process that activates or increases the frequency, rate or extent of p38MAPK cascade.
|
1 | Q3V1N1 (/ISO) |
|
Positive regulation of p38MAPK cascade GO:1900745
Any process that activates or increases the frequency, rate or extent of p38MAPK cascade.
|
1 | Q3V1N1 (/ISS) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9Y4C4 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q3V1N1 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q3V1N1 (/ISS) |
