The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Nucleotide cyclase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15: Guanylate cyclase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
3 P23897 (/IDA) Q6TL19 (/IDA) Q86GV3 (/IDA)
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
2 P25092 (/TAS) P55205 (/TAS)
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
1 Q3UWA6 (/IMP)
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
1 Q3UWA6 (/ISO)
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
1 Q6TL19 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P25092 (/IPI)
Toxic substance binding GO:0015643
Interacting selectively and non-covalently with a toxic substance, a poisonous substance that causes damage to biological systems.
1 P23897 (/IDA)
Toxic substance binding GO:0015643
Interacting selectively and non-covalently with a toxic substance, a poisonous substance that causes damage to biological systems.
1 Q3UWA6 (/ISO)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 Q86GV3 (/IMP)
Receptor guanylyl cyclase signaling pathway GO:0007168
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P25092 (/TAS)
Digestion GO:0007586
The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.
1 P25092 (/TAS)
Sensory perception of chemical stimulus GO:0007606
The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
1 Q86GV3 (/IGI)
Sensory perception of chemical stimulus GO:0007606
The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
1 Q86GV3 (/IMP)
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
1 Q3UWA6 (/IMP)
Olfactory behavior GO:0042048
The behavior of an organism in response to an odor.
1 Q86GV3 (/IMP)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
1 Q3UWA6 (/IGI)
Sensory processing GO:0050893
Any neural process required for an organism to sense and interpret the dimensions of a sensory experience: modality, location, intensity and affect.
1 Q86GV3 (/IGI)
Sensory processing GO:0050893
Any neural process required for an organism to sense and interpret the dimensions of a sensory experience: modality, location, intensity and affect.
1 Q86GV3 (/IMP)
Cardiac muscle cell proliferation GO:0060038
The expansion of a cardiac muscle cell population by cell division.
1 D1LXJ2 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P25092 (/TAS)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 Q6TL19 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q6TL19 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q86GV3 (/IDA)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
1 Q86GV3 (/IDA)
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