The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Glutamine synthetase/guanido kinase, catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Glutamine synthetase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutamate-ammonia ligase activity GO:0004356
Catalysis of the reaction: L-glutamate + ATP + NH(3) = L-glutamine + ADP + 2 H(+) + phosphate.
194 A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA)
(184 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
163 P0A9C5 (/IPI) P0A9C5 (/IPI) P0A9C5 (/IPI) P0A9C5 (/IPI) P0A9C5 (/IPI) P0A9C5 (/IPI) P0A9C5 (/IPI) P0A9C5 (/IPI) P0A9C5 (/IPI) P0A9C5 (/IPI)
(153 more)
Glutamate-ammonia ligase activity GO:0004356
Catalysis of the reaction: L-glutamate + ATP + NH(3) = L-glutamine + ADP + 2 H(+) + phosphate.
18 P15106 (/IMP) P15106 (/IMP) P15106 (/IMP) P15106 (/IMP) P15106 (/IMP) P15106 (/IMP) P15106 (/IMP) P9WN39 (/IMP) P9WN39 (/IMP) P9WN39 (/IMP)
(8 more)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
11 A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA)
(1 more)
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
11 P9WN39 (/IPI) P9WN39 (/IPI) P9WN39 (/IPI) P9WN39 (/IPI) P9WN39 (/IPI) P9WN39 (/IPI) P9WN39 (/IPI) P9WN39 (/IPI) P9WN39 (/IPI) P9WN39 (/IPI)
(1 more)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
11 A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA)
(1 more)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
11 A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA)
(1 more)
GDP binding GO:0019003
Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate.
11 A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA)
(1 more)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
11 A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA)
(1 more)
Zymogen binding GO:0035375
Interacting selectively and non-covalently with a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis.
11 P9WN39 (/IPI) P9WN39 (/IPI) P9WN39 (/IPI) P9WN39 (/IPI) P9WN39 (/IPI) P9WN39 (/IPI) P9WN39 (/IPI) P9WN39 (/IPI) P9WN39 (/IPI) P9WN39 (/IPI)
(1 more)
ADP binding GO:0043531
Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate.
11 A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA)
(1 more)
Cobalt ion binding GO:0050897
Interacting selectively and non-covalently with a cobalt (Co) ion.
11 A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA)
(1 more)
Glutamate-ammonia ligase activity GO:0004356
Catalysis of the reaction: L-glutamate + ATP + NH(3) = L-glutamine + ADP + 2 H(+) + phosphate.
9 Q9KNJ2 (/ISS) Q9KNJ2 (/ISS) Q9KNJ2 (/ISS) Q9KNJ2 (/ISS) Q9KNJ2 (/ISS) Q9KNJ2 (/ISS) Q9KNJ2 (/ISS) Q9KNJ2 (/ISS) Q9KNJ2 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P77961 (/IPI)
3-(hydroxyamino)phenol mutase activity GO:0034022
Catalysis of the reaction: 3-hydroxyaminophenol = aminohydroquinone.
1 Q46ZL2 (/IDA)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to radiation GO:0009314
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.
163 P0A9C5 (/IMP) P0A9C5 (/IMP) P0A9C5 (/IMP) P0A9C5 (/IMP) P0A9C5 (/IMP) P0A9C5 (/IMP) P0A9C5 (/IMP) P0A9C5 (/IMP) P0A9C5 (/IMP) P0A9C5 (/IMP)
(153 more)
Ammonia assimilation cycle GO:0019676
The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen.
163 P0A9C5 (/IDA) P0A9C5 (/IDA) P0A9C5 (/IDA) P0A9C5 (/IDA) P0A9C5 (/IDA) P0A9C5 (/IDA) P0A9C5 (/IDA) P0A9C5 (/IDA) P0A9C5 (/IDA) P0A9C5 (/IDA)
(153 more)
Nitrogen utilization GO:0019740
A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism.
163 P0A9C5 (/IDA) P0A9C5 (/IDA) P0A9C5 (/IDA) P0A9C5 (/IDA) P0A9C5 (/IDA) P0A9C5 (/IDA) P0A9C5 (/IDA) P0A9C5 (/IDA) P0A9C5 (/IDA) P0A9C5 (/IDA)
(153 more)
Glutamine biosynthetic process GO:0006542
The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid.
11 P9WN39 (/IMP) P9WN39 (/IMP) P9WN39 (/IMP) P9WN39 (/IMP) P9WN39 (/IMP) P9WN39 (/IMP) P9WN39 (/IMP) P9WN39 (/IMP) P9WN39 (/IMP) P9WN39 (/IMP)
(1 more)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
11 P9WN39 (/IMP) P9WN39 (/IMP) P9WN39 (/IMP) P9WN39 (/IMP) P9WN39 (/IMP) P9WN39 (/IMP) P9WN39 (/IMP) P9WN39 (/IMP) P9WN39 (/IMP) P9WN39 (/IMP)
(1 more)
Positive regulation of plasminogen activation GO:0010756
Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin.
11 P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA)
(1 more)
Evasion or tolerance of host immune response GO:0020012
Any process, either active or passive, by which an organism avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
11 P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA)
(1 more)
Interaction with host via substance in symbiont surface GO:0044044
An interaction with the host organism mediated by a substance on the surface of the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
11 P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA) P9WN39 (/IDA)
(1 more)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
11 A0A0H3LHU4 (/IPI) A0A0H3LHU4 (/IPI) A0A0H3LHU4 (/IPI) A0A0H3LHU4 (/IPI) A0A0H3LHU4 (/IPI) A0A0H3LHU4 (/IPI) A0A0H3LHU4 (/IPI) A0A0H3LHU4 (/IPI) A0A0H3LHU4 (/IPI) A0A0H3LHU4 (/IPI)
(1 more)
Glutamine biosynthetic process GO:0006542
The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid.
9 Q9KNJ2 (/ISS) Q9KNJ2 (/ISS) Q9KNJ2 (/ISS) Q9KNJ2 (/ISS) Q9KNJ2 (/ISS) Q9KNJ2 (/ISS) Q9KNJ2 (/ISS) Q9KNJ2 (/ISS) Q9KNJ2 (/ISS)
Benzene-containing compound metabolic process GO:0042537
The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives.
1 Q46ZL2 (/IDA)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
174 P0A9C5 (/HDA) P0A9C5 (/HDA) P0A9C5 (/HDA) P0A9C5 (/HDA) P0A9C5 (/HDA) P0A9C5 (/HDA) P0A9C5 (/HDA) P0A9C5 (/HDA) P0A9C5 (/HDA) P0A9C5 (/HDA)
(164 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
174 A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA)
(164 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
163 P0A9C5 (/HDA) P0A9C5 (/HDA) P0A9C5 (/HDA) P0A9C5 (/HDA) P0A9C5 (/HDA) P0A9C5 (/HDA) P0A9C5 (/HDA) P0A9C5 (/HDA) P0A9C5 (/HDA) P0A9C5 (/HDA)
(153 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
22 A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA) A0A0H3LHU4 (/IDA)
(12 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
11 P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA)
(1 more)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
11 P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA)
(1 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
11 P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA) P9WN39 (/HDA)
(1 more)
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