The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
SH2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 63: Tyrosine-protein kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
2 P43403 (/IDA) P43404 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P43403 (/IPI) P43404 (/IPI)
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
1 P43403 (/IMP)
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
1 P43403 (/IPI)
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
1 P43404 (/ISO)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 P43404 (/IDA)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 P43404 (/IMP)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 P43404 (/ISO)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 P43403 (/NAS)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 P43403 (/TAS)
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
1 P43403 (/TAS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P43404 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P43403 (/NAS)

There are 37 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lymphangiogenesis GO:0001946
Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.
2 M9MM92 (/IGI) Q503P3 (/IGI)
Lymphangiogenesis GO:0001946
Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.
2 M9MM92 (/IMP) Q503P3 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 P43403 (/IDA) P43404 (/IDA)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
2 P43403 (/IDA) P43404 (/IDA)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
2 P43403 (/IMP) P43404 (/IMP)
Positive regulation of cell migration involved in sprouting angiogenesis GO:0090050
Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.
2 M9MM92 (/IGI) Q503P3 (/IGI)
Positive regulation of cell migration involved in sprouting angiogenesis GO:0090050
Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.
2 M9MM92 (/IMP) Q503P3 (/IMP)
Adaptive immune response GO:0002250
An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory).
1 P43403 (/TAS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 P43404 (/ISO)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 P43403 (/NAS)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
1 P43403 (/IDA)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
1 P43404 (/ISO)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
1 P43404 (/ISO)
T cell differentiation GO:0030217
The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
1 P43403 (/NAS)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 P43404 (/IMP)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 P43403 (/NAS)
T cell activation GO:0042110
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
1 P43403 (/TAS)
B cell activation GO:0042113
The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
1 P43403 (/TAS)
Beta selection GO:0043366
The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell.
1 P43404 (/IGI)
Positive thymic T cell selection GO:0045059
The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death.
1 P43403 (/IDA)
Positive thymic T cell selection GO:0045059
The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death.
1 P43404 (/IMP)
Positive thymic T cell selection GO:0045059
The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death.
1 P43404 (/ISO)
Negative thymic T cell selection GO:0045060
The process of elimination of immature T cells in the thymus which react strongly with self-antigens.
1 P43404 (/IMP)
Thymic T cell selection GO:0045061
The process of T cell selection that occurs in the thymus.
1 P43404 (/IMP)
Positive regulation of T cell differentiation GO:0045582
Any process that activates or increases the frequency, rate or extent of T cell differentiation.
1 P43403 (/IDA)
Positive regulation of T cell differentiation GO:0045582
Any process that activates or increases the frequency, rate or extent of T cell differentiation.
1 P43404 (/IMP)
Positive regulation of T cell differentiation GO:0045582
Any process that activates or increases the frequency, rate or extent of T cell differentiation.
1 P43404 (/ISO)
Positive regulation of alpha-beta T cell differentiation GO:0046638
Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation.
1 P43404 (/IGI)
Positive regulation of alpha-beta T cell differentiation GO:0046638
Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation.
1 P43404 (/IMP)
Positive regulation of alpha-beta T cell proliferation GO:0046641
Any process that activates or increases the frequency, rate or extent of alpha-beta T cell proliferation.
1 P43404 (/IGI)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 P43404 (/IDA)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 P43404 (/IMP)
Positive regulation of calcium-mediated signaling GO:0050850
Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling.
1 P43404 (/IMP)
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
1 P43404 (/IMP)
T cell receptor signaling pathway GO:0050852
A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
1 P43403 (/TAS)
T cell aggregation GO:0070489
The adhesion of one T cell to one or more other T cells via adhesion molecules.
1 P43403 (/TAS)
T cell migration GO:0072678
The movement of a T cell within or between different tissues and organs of the body.
1 P43403 (/TAS)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P43403 (/IDA) P43404 (/IDA)
Immunological synapse GO:0001772
An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
1 P43404 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P43404 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P43403 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P43404 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P43403 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P43404 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P43403 (/TAS)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 P43404 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P43404 (/IDA)
T cell receptor complex GO:0042101
A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.
1 P43403 (/IDA)
T cell receptor complex GO:0042101
A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.
1 P43404 (/ISO)
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