The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
SH2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 28: Suppressor of cytokine signaling 5

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 O54928 (/IPI) O75159 (/IPI) O75159 (/IPI) O75159 (/IPI) Q8WXH5 (/IPI) Q8WXH5 (/IPI)
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
3 O75159 (/IPI) O75159 (/IPI) O75159 (/IPI)
Sevenless binding GO:0005118
Interacting selectively and non-covalently with the sevenless (sev) protein, a receptor tyrosine kinase.
1 Q8INY1 (/IDA)
Cytokine receptor binding GO:0005126
Interacting selectively and non-covalently with a cytokine receptor.
1 Q8INY1 (/IPI)
Epidermal growth factor receptor binding GO:0005154
Interacting selectively and non-covalently with the epidermal growth factor receptor.
1 O54928 (/IPI)
Kinase inhibitor activity GO:0019210
Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
1 O54928 (/NAS)
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
1 O54928 (/ISO)

There are 41 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of epidermal growth factor-activated receptor activity GO:0007175
Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity.
5 O75159 (/IDA) O75159 (/IDA) O75159 (/IDA) Q8WXH5 (/IDA) Q8WXH5 (/IDA)
Negative regulation of epidermal growth factor-activated receptor activity GO:0007175
Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity.
5 O54928 (/ISS) Q0VC91 (/ISS) Q29RN6 (/ISS) Q5RDX2 (/ISS) Q91ZA6 (/ISS)
Negative regulation of signal transduction GO:0009968
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
4 O54928 (/NAS) O75159 (/NAS) O75159 (/NAS) O75159 (/NAS)
Border follicle cell migration GO:0007298
The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
3 Q86P82 (/IMP) Q8INY1 (/IMP) Q9VJA1 (/IMP)
Haltere development GO:0007482
The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings.
3 Q86P82 (/IMP) Q8INY1 (/IMP) Q9VJA1 (/IMP)
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
3 Q86P82 (/IMP) Q8INY1 (/IMP) Q9VJA1 (/IMP)
Imaginal disc-derived wing vein morphogenesis GO:0008586
The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized.
3 Q86P82 (/IMP) Q8INY1 (/IMP) Q9VJA1 (/IMP)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
3 O75159 (/ISS) O75159 (/ISS) O75159 (/ISS)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
3 O75159 (/TAS) O75159 (/TAS) O75159 (/TAS)
Germ-line stem cell population maintenance GO:0030718
Any process by which an organism or tissue maintains a population of germ-line stem cells.
3 Q86P82 (/IMP) Q8INY1 (/IMP) Q9VJA1 (/IMP)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
3 O75159 (/IMP) O75159 (/IMP) O75159 (/IMP)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
3 Q0VC91 (/ISS) Q5RDX2 (/ISS) Q91ZA6 (/ISS)
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
3 Q86P82 (/IMP) Q8INY1 (/IMP) Q9VJA1 (/IMP)
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
3 O75159 (/TAS) O75159 (/TAS) O75159 (/TAS)
Cell dedifferentiation GO:0043697
The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.
3 Q86P82 (/IGI) Q8INY1 (/IGI) Q9VJA1 (/IGI)
Positive regulation of T-helper 1 cell differentiation GO:0045627
Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation.
3 O75159 (/ISS) O75159 (/ISS) O75159 (/ISS)
Negative regulation of T-helper 2 cell differentiation GO:0045629
Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation.
3 O75159 (/ISS) O75159 (/ISS) O75159 (/ISS)
Negative regulation of receptor signaling pathway via JAK-STAT GO:0046426
Any process that stops, prevents, or reduces the frequency, rate or extent of a receptor signaling pathway via JAK-STAT.
3 Q86P82 (/IGI) Q8INY1 (/IGI) Q9VJA1 (/IGI)
Negative regulation of receptor signaling pathway via JAK-STAT GO:0046426
Any process that stops, prevents, or reduces the frequency, rate or extent of a receptor signaling pathway via JAK-STAT.
3 Q86P82 (/IMP) Q8INY1 (/IMP) Q9VJA1 (/IMP)
Compound eye pigmentation GO:0048072
Establishment of a pattern of pigment in the compound eye.
3 Q86P82 (/IMP) Q8INY1 (/IMP) Q9VJA1 (/IMP)
Notum morphogenesis GO:0048802
The process in which the anatomical structures of the dorsal part of the body are generated and organized.
3 Q86P82 (/IMP) Q8INY1 (/IMP) Q9VJA1 (/IMP)
Negative regulation of epidermal growth factor-activated receptor activity GO:0007175
Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity.
2 O54928 (/ISO) Q91ZA6 (/ISO)
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 O54928 (/IDA)
Receptor signaling pathway via JAK-STAT GO:0007259
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
1 O54928 (/TAS)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 O54928 (/IDA)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
1 O54928 (/ISO)
Negative regulation of interleukin-6 production GO:0032715
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.
1 O54928 (/IMP)
Negative regulation of tyrosine phosphorylation of STAT protein GO:0042532
Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
1 Q8INY1 (/IDA)
Positive regulation of T-helper 1 cell differentiation GO:0045627
Any process that activates or increases the frequency, rate or extent of T-helper 1 cell differentiation.
1 O54928 (/IDA)
Negative regulation of T-helper 2 cell differentiation GO:0045629
Any process that stops, prevents, or reduces the frequency, rate or extent of T-helper 2 cell differentiation.
1 O54928 (/IDA)
Negative regulation of R7 cell differentiation GO:0045677
Any process that stops, prevents, or reduces the frequency, rate or extent of R7cell differentiation.
1 Q8INY1 (/IGI)
Negative regulation of R7 cell differentiation GO:0045677
Any process that stops, prevents, or reduces the frequency, rate or extent of R7cell differentiation.
1 Q8INY1 (/IMP)
Negative regulation of sevenless signaling pathway GO:0045873
Any process that stops, prevents, or reduces the frequency, rate or extent of the sevenless signaling pathway.
1 Q8INY1 (/IDA)
Negative regulation of sevenless signaling pathway GO:0045873
Any process that stops, prevents, or reduces the frequency, rate or extent of the sevenless signaling pathway.
1 Q8INY1 (/IGI)
Negative regulation of receptor signaling pathway via JAK-STAT GO:0046426
Any process that stops, prevents, or reduces the frequency, rate or extent of a receptor signaling pathway via JAK-STAT.
1 Q8INY1 (/IDA)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
1 O54928 (/IMP)
Cellular response to low-density lipoprotein particle stimulus GO:0071404
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus.
1 O54928 (/IMP)
Negative regulation of monocyte chemotactic protein-1 production GO:0071638
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of monocyte chemotactic protein-1.
1 O54928 (/IMP)
Vascular endothelial cell response to fluid shear stress GO:0097699
Any response to fluid shear stress in a vascular endothelial cell.
1 O54928 (/IMP)
Negative regulation of endothelial cell activation GO:1904988
Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell activation.
1 O54928 (/IC)
Positive regulation of lysosomal protein catabolic process GO:1905167
Any process that activates or increases the frequency, rate or extent of lysosomal protein catabolic process.
1 Q8INY1 (/IMP)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 O75159 (/TAS) O75159 (/TAS) O75159 (/TAS) Q91ZA6 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O54928 (/NAS)
CATH-Gene3D is a Global Biodata Core Resource Learn more...