The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Erythroid Transcription Factor GATA-1, subunit A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 47: glucocorticoid receptor isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glucocorticoid receptor activity GO:0004883
Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function.
7 A0A2R8QN75 (/IDA) A0A2R8RNZ4 (/IDA) B1NAT5 (/IDA) F6PEW1 (/IDA) P49843 (/IDA) Q1XHK0 (/IDA) Q6RKQ3 (/IDA)
Steroid hormone binding GO:1990239
Interacting selectively and non-covalently with a steroid hormone.
4 C6KE15 (/ISS) O73673 (/ISS) P49843 (/ISS) Q5I1Z4 (/ISS)
Core promoter sequence-specific DNA binding GO:0001046
Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
2 P49843 (/IDA) Q6RKQ3 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
2 O73673 (/ISS) P49843 (/ISS)
Nuclear receptor activity GO:0004879
Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
2 O73673 (/ISS) P49843 (/ISS)
Glucocorticoid receptor activity GO:0004883
Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function.
2 C6KE15 (/ISS) Q5I1Z4 (/ISS)
Steroid binding GO:0005496
Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.
2 O73673 (/ISS) P49843 (/ISS)
Cortisol receptor activity GO:0031963
Combining with cortisol and transmitting the signal within the cell to trigger a change in cell activity or function.
2 P49843 (/IDA) Q6RKQ3 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
2 C6KE15 (/ISS) Q5I1Z4 (/ISS)
Ligand-activated transcription factor activity GO:0098531
A DNA-binding transcription factor activity that is directly regulated by binding of a ligand to the protein with this activity. Examples include the lac and trp repressors in E.coli and many steroid hormone receptors.
2 P49843 (/IDA) Q6RKQ3 (/IDA)
Steroid hormone binding GO:1990239
Interacting selectively and non-covalently with a steroid hormone.
2 P49843 (/IDA) Q6RKQ3 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 P49843 (/IMP)
Cortisol binding GO:1903794
Interacting selectively and non-covalently with cortisol.
1 Q6RKQ3 (/IC)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to cortisol GO:0051414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions.
7 A0A2R8QN75 (/IDA) A0A2R8RNZ4 (/IDA) B1NAT5 (/IDA) F6PEW1 (/IDA) P49843 (/IDA) Q1XHK0 (/IDA) Q6RKQ3 (/IDA)
Response to cortisol GO:0051414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions.
7 A0A2R8QN75 (/IMP) A0A2R8RNZ4 (/IMP) B1NAT5 (/IMP) F6PEW1 (/IMP) P49843 (/IMP) Q1XHK0 (/IMP) Q6RKQ3 (/IMP)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
6 A0A2R8QN75 (/IMP) A0A2R8RNZ4 (/IMP) B1NAT5 (/IMP) F6PEW1 (/IMP) Q1XHK0 (/IMP) Q6RKQ3 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
5 A0A2R8QN75 (/IDA) A0A2R8RNZ4 (/IDA) B1NAT5 (/IDA) F6PEW1 (/IDA) Q1XHK0 (/IDA)
Regulation of metabolic process GO:0019222
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
5 A0A2R8QN75 (/IMP) A0A2R8RNZ4 (/IMP) B1NAT5 (/IMP) F6PEW1 (/IMP) Q1XHK0 (/IMP)
Multicellular organismal response to stress GO:0033555
Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
5 A0A2R8QN75 (/IEP) A0A2R8RNZ4 (/IEP) B1NAT5 (/IEP) F6PEW1 (/IEP) Q1XHK0 (/IEP)
Light adaption GO:0036367
The ability of a photoreceptor to adjust to varying levels of light.
5 A0A2R8QN75 (/IMP) A0A2R8RNZ4 (/IMP) B1NAT5 (/IMP) F6PEW1 (/IMP) Q1XHK0 (/IMP)
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
5 A0A2R8QN75 (/IMP) A0A2R8RNZ4 (/IMP) B1NAT5 (/IMP) F6PEW1 (/IMP) Q1XHK0 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
5 A0A2R8QN75 (/IDA) A0A2R8RNZ4 (/IDA) B1NAT5 (/IDA) F6PEW1 (/IDA) Q1XHK0 (/IDA)
Circadian behavior GO:0048512
The specific behavior of an organism that recurs with a regularity of approximately 24 hours.
5 A0A2R8QN75 (/IGI) A0A2R8RNZ4 (/IGI) B1NAT5 (/IGI) F6PEW1 (/IGI) Q1XHK0 (/IGI)
Embryonic viscerocranium morphogenesis GO:0048703
The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones.
5 A0A2R8QN75 (/IMP) A0A2R8RNZ4 (/IMP) B1NAT5 (/IMP) F6PEW1 (/IMP) Q1XHK0 (/IMP)
Ion homeostasis GO:0050801
Any process involved in the maintenance of an internal steady state of ions within an organism or cell.
5 A0A2R8QN75 (/IMP) A0A2R8RNZ4 (/IMP) B1NAT5 (/IMP) F6PEW1 (/IMP) Q1XHK0 (/IMP)
Calcium ion homeostasis GO:0055074
Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell.
5 A0A2R8QN75 (/IMP) A0A2R8RNZ4 (/IMP) B1NAT5 (/IMP) F6PEW1 (/IMP) Q1XHK0 (/IMP)
Sodium ion homeostasis GO:0055078
Any process involved in the maintenance of an internal steady state of sodium ions within an organism or cell.
5 A0A2R8QN75 (/IMP) A0A2R8RNZ4 (/IMP) B1NAT5 (/IMP) F6PEW1 (/IMP) Q1XHK0 (/IMP)
Calcium ion import GO:0070509
The directed movement of calcium ions into a cell or organelle.
5 A0A2R8QN75 (/IMP) A0A2R8RNZ4 (/IMP) B1NAT5 (/IMP) F6PEW1 (/IMP) Q1XHK0 (/IMP)
Response to dexamethasone GO:0071548
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dexamethasone stimulus.
5 A0A2R8QN75 (/IDA) A0A2R8RNZ4 (/IDA) B1NAT5 (/IDA) F6PEW1 (/IDA) Q1XHK0 (/IDA)
Proton export across plasma membrane GO:0120029
The directed movement of hydrogen ions (protons) from inside a cell, across the plasma membrane and into the extracellular region.
5 A0A2R8QN75 (/IMP) A0A2R8RNZ4 (/IMP) B1NAT5 (/IMP) F6PEW1 (/IMP) Q1XHK0 (/IMP)
Regulation of hematopoietic stem cell differentiation GO:1902036
Any process that modulates the frequency, rate or extent of hematopoietic stem cell differentiation.
5 A0A2R8QN75 (/IMP) A0A2R8RNZ4 (/IMP) B1NAT5 (/IMP) F6PEW1 (/IMP) Q1XHK0 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 P49843 (/IDA) Q6RKQ3 (/IDA)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 C6KE15 (/ISS) Q5I1Z4 (/ISS)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 O73673 (/ISS) P49843 (/ISS)
Response to copper ion GO:0046688
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
2 C6KE15 (/ISS) Q5I1Z4 (/ISS)
Response to cortisol GO:0051414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cortisol stimulus. Cortisol is the major natural glucocorticoid synthesized in the zona fasciculata of the adrenal cortex; it affects the metabolism of glucose, protein, and fats and has appreciable mineralocorticoid activity. It also regulates the immune system and affects many other functions.
2 C6KE15 (/ISS) Q5I1Z4 (/ISS)
Cellular response to steroid hormone stimulus GO:0071383
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a steroid hormone stimulus.
2 O73673 (/ISS) P49843 (/ISS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q6RKQ3 (/IMP)
Negative regulation of receptor biosynthetic process GO:0010871
Any process that decreases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q6RKQ3 (/IMP)
Negative regulation of intracellular estrogen receptor signaling pathway GO:0033147
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.
1 Q6RKQ3 (/IMP)
Response to copper ion GO:0046688
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
1 P49843 (/IDA)
Cellular response to glucocorticoid stimulus GO:0071385
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 O73673 (/ISS)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 A0A2R8QN75 (/IDA) A0A2R8RNZ4 (/IDA) B1NAT5 (/IDA) F6PEW1 (/IDA) P49843 (/IDA) Q1XHK0 (/IDA) Q6RKQ3 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 A0A2R8QN75 (/IDA) A0A2R8RNZ4 (/IDA) B1NAT5 (/IDA) F6PEW1 (/IDA) P49843 (/IDA) Q1XHK0 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 C6KE15 (/ISS) O73673 (/ISS) P49843 (/ISS) Q5I1Z4 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 C6KE15 (/ISS) O73673 (/ISS) P49843 (/ISS) Q5I1Z4 (/ISS)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
2 C6KE15 (/ISS) Q5I1Z4 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P49843 (/IMP) Q6RKQ3 (/IMP)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P49843 (/IMP) Q6RKQ3 (/IMP)
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
2 O73673 (/ISS) P49843 (/ISS)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
1 P49843 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q6RKQ3 (/IDA)
Basolateral part of cell GO:1990794
The region of a cell situated by the cell sides which interface adjacent cells and near the base. Often used in reference to animal polarized epithelial cells.
1 P49843 (/IDA)
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