The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Band 7 domain
".
FunFam 9: Erlin-2 isoform 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
11 |
O75477 (/IPI)
O75477 (/IPI)
O75477 (/IPI)
O94905 (/IPI)
O94905 (/IPI)
O94905 (/IPI)
O94905 (/IPI)
O94905 (/IPI)
O94905 (/IPI)
O94905 (/IPI)
(1 more) |
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
7 | O94905 (/IPI) O94905 (/IPI) O94905 (/IPI) O94905 (/IPI) O94905 (/IPI) O94905 (/IPI) O94905 (/IPI) |
Cholesterol binding GO:0015485
Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
3 | O75477 (/IDA) O75477 (/IDA) O75477 (/IDA) |
Cholesterol binding GO:0015485
Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
1 | Q91X78 (/ISO) |
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
1 | Q8BFZ9 (/ISO) |
There are 9 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Ubiquitin-dependent ERAD pathway GO:0030433
The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
|
10 | O75477 (/IDA) O75477 (/IDA) O75477 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) |
SREBP signaling pathway GO:0032933
A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.
|
10 | O75477 (/IMP) O75477 (/IMP) O75477 (/IMP) O94905 (/IMP) O94905 (/IMP) O94905 (/IMP) O94905 (/IMP) O94905 (/IMP) O94905 (/IMP) O94905 (/IMP) |
Negative regulation of cholesterol biosynthetic process GO:0045541
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.
|
10 | O75477 (/IMP) O75477 (/IMP) O75477 (/IMP) O94905 (/IMP) O94905 (/IMP) O94905 (/IMP) O94905 (/IMP) O94905 (/IMP) O94905 (/IMP) O94905 (/IMP) |
Negative regulation of fatty acid biosynthetic process GO:0045717
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.
|
10 | O75477 (/IMP) O75477 (/IMP) O75477 (/IMP) O94905 (/IMP) O94905 (/IMP) O94905 (/IMP) O94905 (/IMP) O94905 (/IMP) O94905 (/IMP) O94905 (/IMP) |
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
|
10 | O75477 (/TAS) O75477 (/TAS) O75477 (/TAS) O94905 (/TAS) O94905 (/TAS) O94905 (/TAS) O94905 (/TAS) O94905 (/TAS) O94905 (/TAS) O94905 (/TAS) |
Ubiquitin-dependent ERAD pathway GO:0030433
The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
|
2 | Q8BFZ9 (/ISO) Q91X78 (/ISO) |
SREBP signaling pathway GO:0032933
A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.
|
2 | Q8BFZ9 (/ISO) Q91X78 (/ISO) |
Negative regulation of cholesterol biosynthetic process GO:0045541
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.
|
2 | Q8BFZ9 (/ISO) Q91X78 (/ISO) |
Negative regulation of fatty acid biosynthetic process GO:0045717
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.
|
2 | Q8BFZ9 (/ISO) Q91X78 (/ISO) |
There are 19 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
14 |
E5RHW4 (/IDA)
E5RHW4 (/IDA)
E5RHW4 (/IDA)
O75477 (/IDA)
O75477 (/IDA)
O75477 (/IDA)
O94905 (/IDA)
O94905 (/IDA)
O94905 (/IDA)
O94905 (/IDA)
(4 more) |
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
11 |
Q5R7C5 (/ISS)
Q5R7C5 (/ISS)
Q5R7C5 (/ISS)
Q5R7C5 (/ISS)
Q5R7C5 (/ISS)
Q5R7C5 (/ISS)
Q5R7C5 (/ISS)
Q5RCJ9 (/ISS)
Q5RCJ9 (/ISS)
Q8BFZ9 (/ISS)
(1 more) |
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
10 | O75477 (/IDA) O75477 (/IDA) O75477 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) |
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
10 | O75477 (/TAS) O75477 (/TAS) O75477 (/TAS) O94905 (/TAS) O94905 (/TAS) O94905 (/TAS) O94905 (/TAS) O94905 (/TAS) O94905 (/TAS) O94905 (/TAS) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
10 | E5RHW4 (/IDA) E5RHW4 (/IDA) E5RHW4 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
10 | E5RHW4 (/IDA) E5RHW4 (/IDA) E5RHW4 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
10 | O75477 (/IDA) O75477 (/IDA) O75477 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
7 | O94905 (/TAS) O94905 (/TAS) O94905 (/TAS) O94905 (/TAS) O94905 (/TAS) O94905 (/TAS) O94905 (/TAS) |
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
|
7 | O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) O94905 (/IDA) |
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
2 | Q8BFZ9 (/ISO) Q91X78 (/ISO) |
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
2 | Q8BFZ9 (/ISO) Q91X78 (/ISO) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
2 | Q8BFZ9 (/ISO) Q91X78 (/ISO) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
1 | Q9ZQ87 (/IDA) |
Vacuolar membrane GO:0005774
The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
|
1 | Q9ZQ87 (/IDA) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
1 | Q9ZQ87 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q8BFZ9 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q8BFZ9 (/ISO) |
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
|
1 | Q9ZQ87 (/IDA) |
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
|
1 | Q8BFZ9 (/ISO) |