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CATH Superfamily 3.30.470.20

ATP-grasp fold, B domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
ATP-grasp fold, B domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: Glutathione synthetase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
 110 P04425 (/IDA) P04425 (/IDA) P04425 (/IDA) P04425 (/IDA) P04425 (/IDA) P04425 (/IDA) P04425 (/IDA) P04425 (/IDA) P04425 (/IDA) P04425 (/IDA)
(100 more)
Glutathione synthase activity GO:0004363
Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.
 110 P04425 (/IDA) P04425 (/IDA) P04425 (/IDA) P04425 (/IDA) P04425 (/IDA) P04425 (/IDA) P04425 (/IDA) P04425 (/IDA) P04425 (/IDA) P04425 (/IDA)
(100 more)
Glutathione synthase activity GO:0004363
Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.
 8 Q8EIK8 (/ISS) Q9KUP7 (/ISS) Q9KUP7 (/ISS) Q9KUP7 (/ISS) Q9KUP7 (/ISS) Q9KUP7 (/ISS) Q9KUP7 (/ISS) Q9KUP7 (/ISS)

There are 2 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutathione biosynthetic process GO:0006750
The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
 110 P04425 (/IMP) P04425 (/IMP) P04425 (/IMP) P04425 (/IMP) P04425 (/IMP) P04425 (/IMP) P04425 (/IMP) P04425 (/IMP) P04425 (/IMP) P04425 (/IMP)
(100 more)
Glutathione biosynthetic process GO:0006750
The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
 8 Q8EIK8 (/ISS) Q9KUP7 (/ISS) Q9KUP7 (/ISS) Q9KUP7 (/ISS) Q9KUP7 (/ISS) Q9KUP7 (/ISS) Q9KUP7 (/ISS) Q9KUP7 (/ISS)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 110 P04425 (/HDA) P04425 (/HDA) P04425 (/HDA) P04425 (/HDA) P04425 (/HDA) P04425 (/HDA) P04425 (/HDA) P04425 (/HDA) P04425 (/HDA) P04425 (/HDA)
(100 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 110 P04425 (/IDA) P04425 (/IDA) P04425 (/IDA) P04425 (/IDA) P04425 (/IDA) P04425 (/IDA) P04425 (/IDA) P04425 (/IDA) P04425 (/IDA) P04425 (/IDA)
(100 more)
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