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CATH Superfamily 3.30.470.160

Inositol polyphosphate kinase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Inositol polyphosphate kinase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: Inositol polyphosphate multikinase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Inositol-polyphosphate multikinase. [EC: 2.7.1.151]
2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.
  • This enzyme also phosphorylates Ins(1,4,5)P(3) to Ins(1,3,4,5)P(4), Ins(1,3,4,5)P(4) to Ins(1,3,4,5,6)P(5), and Ins(1,3,4,5,6)P(4) to Ins(PP)P(4), isomer unknown.
  • The enzyme from the plant Arabidopsis thaliana can also phosphorylate Ins(1,3,4,6)P(4) and Ins(1,2,3,4,6)P(5) at the D-5-position to produce 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate (InsP(6)), respectively.
  • Yeast produces InsP(6) from Ins(1,4,5)P(3) by the actions of this enzyme and EC 2.7.1.158.
 16 A0A0L8VT81 A0A0L8VT81 A0A0L8VT81 A0A0L8VT81 B3LGB0 B3LGB0 B3LGB0 B3LGB0 C7GN24 C7GN24
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