The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Inositol polyphosphate kinase
".
FunFam 1: Kinase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 14 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Inositol-1,4,5-trisphosphate 3-kinase activity GO:0008440
Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+).
|
7 | B2RXC2 (/IDA) P17105 (/IDA) P27987 (/IDA) Q7KV26 (/IDA) Q7TS72 (/IDA) Q9VYE6 (/IDA) Q9VYE7 (/IDA) |
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
|
3 | Q7KV26 (/IDA) Q9VYE6 (/IDA) Q9VYE7 (/IDA) |
Inositol-1,4,5-trisphosphate 3-kinase activity GO:0008440
Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+).
|
3 | P23677 (/TAS) P23677 (/TAS) P23677 (/TAS) |
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
|
3 | Q7KV26 (/IDA) Q9VYE6 (/IDA) Q9VYE7 (/IDA) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P27987 (/IPI) Q7TS72 (/IPI) |
Inositol-1,4,5-trisphosphate 3-kinase activity GO:0008440
Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+).
|
2 | B2RXC2 (/IMP) P17105 (/IMP) |
Inositol-1,4,5-trisphosphate 3-kinase activity GO:0008440
Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+).
|
2 | B2RXC2 (/ISO) Q8R071 (/ISO) |
Calmodulin-dependent protein kinase activity GO:0004683
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin.
|
1 | P17105 (/IDA) |
Calmodulin-dependent protein kinase activity GO:0004683
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin.
|
1 | Q8R071 (/ISO) |
Inositol-1,4,5-trisphosphate 3-kinase activity GO:0008440
Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+).
|
1 | P42335 (/ISS) |
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
|
1 | Q80ZG2 (/IDA) |
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
|
1 | Q7TS72 (/ISO) |
Rac GTPase binding GO:0048365
Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.
|
1 | P17105 (/IDA) |
Rac GTPase binding GO:0048365
Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.
|
1 | Q8R071 (/ISO) |
There are 34 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Inositol phosphate metabolic process GO:0043647
The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
|
6 | P23677 (/TAS) P23677 (/TAS) P23677 (/TAS) P27987 (/TAS) Q96DU7 (/TAS) Q96DU7 (/TAS) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
4 | P23677 (/TAS) P23677 (/TAS) P23677 (/TAS) P27987 (/TAS) |
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
3 | M9ND56 (/IMP) Q95R55 (/IMP) Q9VL83 (/IMP) |
Inositol phosphate biosynthetic process GO:0032958
The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
|
3 | Q7KV26 (/IDA) Q9VYE6 (/IDA) Q9VYE7 (/IDA) |
Salivary gland cell autophagic cell death GO:0035071
The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis.
|
3 | Q7KV26 (/IGI) Q9VYE6 (/IGI) Q9VYE7 (/IGI) |
Salivary gland cell autophagic cell death GO:0035071
The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis.
|
3 | Q7KV26 (/IMP) Q9VYE6 (/IMP) Q9VYE7 (/IMP) |
Inositol trisphosphate metabolic process GO:0032957
The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached.
|
2 | B2RXC2 (/ISS) P42335 (/ISS) |
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
|
2 | B2RXC2 (/ISS) P42335 (/ISS) |
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
|
1 | B2RXC2 (/IMP) |
Regulation of protein phosphorylation GO:0001932
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
|
1 | B2RXC2 (/IMP) |
Myeloid cell homeostasis GO:0002262
The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.
|
1 | B2RXC2 (/IMP) |
Inositol metabolic process GO:0006020
The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.
|
1 | Q8R071 (/IMP) |
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
1 | B2RXC2 (/IMP) |
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | P17105 (/IGI) |
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | P17105 (/IMP) |
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | Q8R071 (/ISO) |
T cell differentiation GO:0030217
The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
|
1 | B2RXC2 (/IMP) |
Inositol trisphosphate metabolic process GO:0032957
The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached.
|
1 | P27987 (/IDA) |
Inositol trisphosphate metabolic process GO:0032957
The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached.
|
1 | B2RXC2 (/ISO) |
Negative regulation of neutrophil apoptotic process GO:0033030
Any process that stops, prevents, or reduces the frequency, rate, or extent of neutrophil apoptotic process.
|
1 | B2RXC2 (/IMP) |
Common myeloid progenitor cell proliferation GO:0035726
The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage.
|
1 | B2RXC2 (/IMP) |
Positive thymic T cell selection GO:0045059
The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death.
|
1 | B2RXC2 (/IMP) |
Thymic T cell selection GO:0045061
The process of T cell selection that occurs in the thymus.
|
1 | B2RXC2 (/IMP) |
Negative regulation of myeloid cell differentiation GO:0045638
Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid cell differentiation.
|
1 | B2RXC2 (/IMP) |
Positive regulation of Ras protein signal transduction GO:0046579
Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction.
|
1 | B2RXC2 (/IMP) |
Positive regulation of alpha-beta T cell differentiation GO:0046638
Any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation.
|
1 | B2RXC2 (/IMP) |
Regulation of synaptic plasticity GO:0048167
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
|
1 | Q8R071 (/IMP) |
Hermaphrodite genitalia morphogenesis GO:0048815
The process in which the anatomical structures of hermaphrodite genitalia are generated and organized.
|
1 | Q95Q62 (/IGI) |
Positive regulation of dendritic spine morphogenesis GO:0061003
Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
1 | P17105 (/IMP) |
Positive regulation of dendritic spine morphogenesis GO:0061003
Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
1 | Q8R071 (/ISO) |
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
|
1 | P27987 (/IDA) |
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
|
1 | B2RXC2 (/ISO) |
Dendritic spine maintenance GO:0097062
The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.
|
1 | P17105 (/IMP) |
Dendritic spine maintenance GO:0097062
The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.
|
1 | Q8R071 (/ISO) |
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
6 | M9ND56 (/IDA) Q7KV26 (/IDA) Q95R55 (/IDA) Q9VL83 (/IDA) Q9VYE6 (/IDA) Q9VYE7 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
6 | P23677 (/TAS) P23677 (/TAS) P23677 (/TAS) P27987 (/TAS) Q96DU7 (/TAS) Q96DU7 (/TAS) |
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
4 | A0A024R0N8 (/IDA) A0A024R0N8 (/IDA) Q96DU7 (/IDA) Q96DU7 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | B2RXC2 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | B2RXC2 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | B2RXC2 (/IDA) |
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
1 | Q7TS72 (/ISO) |
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
|
1 | P17105 (/IDA) |
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
|
1 | Q8R071 (/ISO) |