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CATH Superfamily 3.30.470.10

Aminotransferase class 4, branched-chain amino acid transferase, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Aminotransferase class 4, branched-chain amino acid transferase, N-terminal domain

Branched-chain aminotransferase (BCAT) catalyses the transamination of the branched-chain amino acids leucine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two forms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme PMID:12686109. BCATs belong to the class 4 type aminotransferases and are widely distributed in many species PMID:22984263. This entry represents the N--terminal domain of BCATs. PMID:12686109 PMID:22984263

GO Diversity

Unique GO annotations
53 Unique GO terms

EC Diversity

Unique EC annotations
4 Unique EC terms

Species Diversity

Unique species annotations
15679 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 270
Domain clusters (>95% seq id): 34
Domain clusters (>35% seq id): 17
Unique PDBs: 99
Alignments
Structural Clusters (5A): 2
Structural Clusters (9A): 2
FunFam Clusters: 56
Function
Unique EC: 4
Unique GO: 53
Taxonomy
Unique Species: 15679
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