The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1PTS-dependent dihydroxyacetone kinase operon regulatory proteinHeat-inducible transcription repressor HrcASC:2DNA-binding transcriptional regulator KdgRHTH-type transcriptional repressor AllRAcetate operon transcriptional repressor IclRIclR family transcriptional regulatorSC:3PhosphodiesterasePhosphodiesteraseStage V sporulation protein TTwo-component sensor histidine kinase KdpDFree methionine-R-sulfoxide reductasePelDSensor cyclic diguanylate phosphodiesterase, GAF and GAF domain-containingSC:4PhosphodiesterasePhosphodiesteraseSC:5Phytochrome-like protein cph2SC:6PhytochromeBacteriophytochrome proteinBacteriophytochrome (Light-regulated signal transduction histidine kinase), PhyB2PhosphodiesteraseIclR family transcriptional regulatorGTP-sensing transcriptional pleiotropic repressor CodYPhosphodiesterasePhosphodiesteraseGAF domain-containing proteinsPhosphodiesterasePhosphoenolpyruvate-protein phosphotransferase PtsPSensor histidine kinase YehUPhosphodiesteraseHeat-inducible transcription repressor HrcAPhosphodiesteraseHeat-inducible transcription repressor HrcAAnaerobic nitric oxide reductase transcription regulator NorRIclR family transcriptional regulatorFormate hydrogenlyase transcriptional activatorEthylene response sensorSensor histidine kinase YpdAPAS domain S-boxPAS domain S-boxIclR family transcriptional regulatorPhosphodiesterasePhosphodiesteraseTranscriptional regulator, IclR familySensor domain-containing diguanylate cyclasePAS sensor proteinIclR family transcriptional regulatorPAS sensor proteinIclR family transcriptional regulatorFormate hydrogenlyase transcriptional activatorIclR family transcriptional regulatorProbable diguanylate cyclase YeaPPhosphodiesterasePutative sensor histidine kinase/response regulatorHeat-inducible transcription repressor HrcAPhosphodiesteraseIclR family transcriptional regulatorHeat-inducible transcription repressor HrcATranscriptional regulator, IclR familyABC1 family protein C21C3.03Oxygen sensor histidine kinase response regulator DevS/DosSIclR family transcriptional regulatorDiguanylate cyclase (GGDEF) domain proteinIclR family transcriptional regulatorIclR family transcriptional regulatorTwo-component system sensor moleculeGAF domain-containing proteinIclR family transcriptional regulatorStage II sporulation protein EAdenylate/guanylate cyclase catalytic domain proteinAdenylate/guanylate cyclase catalytic domain proteinStage II sporulation protein EIclR family transcriptional regulatorHydrogenase-4 transcriptional activatorTwo-component system sensor histidine kinase KdpDPhosphodiesteraseDiguanylate cyclase (GGDEF) domain proteinPutative transcriptional regulatorUnplaced genomic scaffold supercont1.28, whole genome shotgun sequenceIclR family transcriptional regulatorPAS domain-containing proteinStage II sporulation protein EPhosphodiesteraseBifunctional diguanylate cyclase/phosphodiesteraseIclR family transcriptional regulatorStage II sporulation protein EHeat-inducible transcription repressor HrcATwo component sensor histidine kinaseVanadium nitrogenase sigma54-dependent transcriptional activator, VnfASensor histidine kinaseSensor histidine kinase/response regulator, putative (AFU_orthologue AFUA_4G00660)IclR family transcriptional regulatorPAS/PAC sensor proteinPhosphatasePhosphoserine phosphatase RsbPHeat-inducible transcription repressor HrcASigma-54-dependent Fis family transcriptional regulatorPutative transcriptional regulatorIclR family transcriptional regulatorCrp family transcriptional regulatorIclR family transcriptional regulatordual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A-likeTranscriptional regulator, IclR familyIclR family transcriptional regulatorTwo-component sensor histidine kinaseIclR family transcriptional regulatorSensor histidine kinase, KdpDGAF modulated transcriptional regulator, LuxR familySigma-54 dependent transcriptional regulatorPhosphataseTranscriptional regulatory proteinIclR family transcriptional regulatorTranscriptional regulator, IclR familyTranscriptional regulatory proteinSensor histidine kinase KdpDGAF domain-containing proteinStage II sporulation protein EHistidine kinase sensor proteinIclR family transcriptional regulatorHeat-inducible transcription repressor HrcAHistidine kinaseIclR family transcriptional regulatorTranscriptional regulator, IclR familyIclR family transcriptional regulatorDiguanylate cyclase-related enzymeDiguanylate cyclase-related enzymeTwo-component sensor KdpDSensory transduction histidine kinaseSerine/threonine protein phosphatasePhytochrome-like proteinSigma-54-dependent Fis family transcriptional regulatorSigma-54 dependent transcriptional regulatorTranscriptional regulator, IclR familySerine/threonine-protein phosphataseSigma factor sigB regulation protein rsbUHelix-turn-helix transcriptional regulator, IclR familyTranscriptional regulatorTranscriptional regulatory proteinTranscriptional regulatory proteinTranscriptional regulatory proteinIclR family transcriptional regulatorTranscriptional regulatory proteinBacteriophytochromePhosphodiesteraseSensory transduction histidine kinasePhosphodiesteraseHistidine kinaseAdenylate cyclaseHistidine kinasePhytochromeProtein serine phosphatase with GAF(S) sensor(S)Stage II sporulation protein EHeat-inducible transcription repressor HrcAIclR family transcriptional regulatorHybrid sensory kinaseIclR family transcriptional regulatorIclR family transcriptional regulatorTranscriptional regulatorHeat-inducible transcription repressor HrcASensory transduction histidine kinaseHistidine kinase osmosensor and regulator, putativeStage II sporulation E family proteinTwo-component system sensor histidine kinase/response regulatorSensory transduction histidine kinaseSensor histidine kinase/response regulator, putativeDiguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S)PAS/PAC sensor-containing diguanylate cyclase/phosphodiesteraseGAF sensor signal transduction histidine kinaseHeat-inducible transcription repressor HrcAGGDEF family proteinDiguanylate cyclaseHistidine kinasePAS sensor proteinPhosphodiesteraseStage II sporulation E family proteinSigma factor SibG regulation protein RsbUPhosphoenolpyruvate-protein phosphotransferaseUncharacterized proteinRegulator of polyketide synthase expressionTranscriptional regulator, IclR familyProbable HTH-type transcriptional regulator ArcRIclR family transcriptional regulatorIclR family transcriptional regulatorIclR family transcriptional regulatorIclR family transcriptional regulatorIclR family transcriptional regulatorIclR family transcriptional regulatorTranscriptional regulatorGGDEF domain-containing proteinDiguanylate cyclaseGAF sensor signal transduction histidine kinaseGAF domain-containing proteinATP-binding region ATPase domain proteinATP-binding region ATPase domain proteinUncharacterized proteinGAF domain-like proteinUncharacterized proteinTwo-component hybrid sensor and regulatorHistidine kinase dimerisation and phosphoacceptor regionPolyketide synthasePAS sensor proteinStage II sporulation E family proteinGAF domain-containing proteinHistidine kinaseSensor cyclic diguanylate phosphodiesterase, GAF and GAF domain-containingAdenylyl cyclase class-3/4/guanylyl cyclaseGAF sensor methyl-accepting chemotaxis sensory transducer, class 40HStage II sporulation E family proteinGAF domain-containing proteinStage II sporulation E family proteinPAS sensor proteinSodium/solute symporter, GAF and PP2C family protein serine/threonine phosphatase domain proteinHistidine kinaseGAF domain proteinUncharacterized proteinGuanylate cyclasePleD gene productPca regulon regulatory proteinPleD gene productSlr1385 proteinPhytochrome-like protein cph1Phytochrome-like protein cph2GAF domain-containing proteinPca regulon regulatory proteinTwo-component signal transductionPAS sensor proteinSerine phosphatase RsbU, regulator of sigma subunitPAS domain-containing proteinSensor histidine kinase, PAS and GAF domain-containingGAF domain-containing proteinHeat-inducible transcription repressor HrcAHeat-inducible transcription repressor HrcAHeat-inducible transcription repressor HrcAHeat-inducible transcription repressor HrcASensor domain-containing diguanylate cyclaseDiguanylate cyclase with GAF sensory domainSensor diguanylate cyclase, GAF domain-containingGGDEF family proteinPleDSensor histidine kinase, GAF domain-containingSensor histidine kinase, GAF domain-containingPhosphodiesterasePhosphodiesterasePhosphodiesterasePhosphodiesterasePhosphodiesteraseSensory transduction histidine kinasePhosphodiesteraseTwo component signal transduction system histidine kinase with GAF sensory domainPhosphodiesteraseUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinGAF domain phosphoenolpyruvate--protein phosphotransferase PtsPSensor histidine kinase, GAF domain-containingTranscriptional regulator (IclR family)Transcriptional regulatorProbable transcriptional regulatorTranscriptional regulatory proteinProbable IclR family regulator (Putative secreted protein)Heat-inducible transcription repressor HrcAChromosome 21, whole genome shotgun sequenceUncharacterized proteinChromosome 21, whole genome shotgun sequenceUncharacterized proteinOsmosensitive potassium channel sensor histidine kinase KdpD, KdpD and USP_OKCHK domain-containingAGAP012811-PAUncharacterized proteinHistidine kinase dimerisation and phosphoacceptor regionPAS sensor proteinHistidine kinasePAS sensor proteinSensory transduction histidine kinaseHistidine kinaseUncharacterized proteinReceptor-like histidine kinase BpdSPhosphodiesteraseDiguanylate cyclase with PAS/PAC sensorTwo-component response regulatorPhosphodiesterasePhosphodiesterasePhosphodiesterasePhosphodiesterasePhosphodiesteraseSensory transduction histidine kinasePhosphodiesterasePhosphodiesteraseUncharacterized proteinPhosphodiesterasePhosphodiesterasecGMP-specific 3',5'-cyclic phosphodiesterasePhosphodiesterasePAS sensor proteinPAS sensor proteinAcetoin catabolism regulatory proteinHistidine kinaseSensor histidine kinase, PAS and GAF domain-containingGlr3986 proteinPAS sensor proteinUncharacterized proteinPAS sensor proteinTwo-component hybrid sensor and regulatorHeat-inducible transcription repressor HrcASensory box/ggdef domain proteinPutative signaling proteinPhosphodiesterasePhosphodiesterasePhosphodiesterasePhosphodiesterasePhosphodiesterasePhosphodiesterasePhosphodiesterase 11a,-likePhosphodiesterase
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FunFam 90: Putative transcriptional regulator

There are 0 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

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