The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
eRF1 domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Eukaryotic peptide chain release factor subunit 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 19 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Translation termination factor activity GO:0008079
Functions in the termination of translation.
279 P35615 (/ISS) P35615 (/ISS) P62496 (/ISS) P62496 (/ISS) P62496 (/ISS) P62496 (/ISS) P62496 (/ISS) P62496 (/ISS) P62496 (/ISS) P62496 (/ISS)
(269 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
72 D2K759 (/IPI) D2K759 (/IPI) D2K759 (/IPI) D2K759 (/IPI) D2K759 (/IPI) D2K759 (/IPI) P12385 (/IPI) P12385 (/IPI) P12385 (/IPI) P12385 (/IPI)
(62 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
55 P62495 (/HDA) P62495 (/HDA) P62495 (/HDA) P62495 (/HDA) P62495 (/HDA) P62495 (/HDA) P62495 (/HDA) P62495 (/HDA) P62495 (/HDA) P62495 (/HDA)
(45 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
55 P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS)
(45 more)
Translation release factor activity GO:0003747
Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.
55 Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO)
(45 more)
Translation release factor activity GO:0003747
Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.
55 P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS)
(45 more)
Translation termination factor activity GO:0008079
Functions in the termination of translation.
55 P62495 (/IMP) P62495 (/IMP) P62495 (/IMP) P62495 (/IMP) P62495 (/IMP) P62495 (/IMP) P62495 (/IMP) P62495 (/IMP) P62495 (/IMP) P62495 (/IMP)
(45 more)
Translation termination factor activity GO:0008079
Functions in the termination of translation.
55 Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO)
(45 more)
Translation termination factor activity GO:0008079
Functions in the termination of translation.
55 P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS)
(45 more)
Ribosome binding GO:0043022
Interacting selectively and non-covalently with any part of a ribosome.
55 P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS)
(45 more)
Sequence-specific mRNA binding GO:1990825
Interacting selectively and non-covalently with messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif.
55 P62495 (/IMP) P62495 (/IMP) P62495 (/IMP) P62495 (/IMP) P62495 (/IMP) P62495 (/IMP) P62495 (/IMP) P62495 (/IMP) P62495 (/IMP) P62495 (/IMP)
(45 more)
Sequence-specific mRNA binding GO:1990825
Interacting selectively and non-covalently with messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif.
55 Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO)
(45 more)
Translation release factor activity GO:0003747
Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.
12 O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS)
(2 more)
Translation release factor activity GO:0003747
Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.
10 P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA)
Translation release factor activity, codon specific GO:0016149
A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site.
10 P12385 (/IMP) P12385 (/IMP) P12385 (/IMP) P12385 (/IMP) P12385 (/IMP) P12385 (/IMP) P12385 (/IMP) P12385 (/IMP) P12385 (/IMP) P12385 (/IMP)
Translation release factor activity GO:0003747
Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.
6 P35614 (/IGI) P35614 (/IGI) Q39097 (/IGI) Q39097 (/IGI) Q9LPV8 (/IGI) Q9LPV8 (/IGI)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 P79063 (/IPI)
Translation release factor activity, codon specific GO:0016149
A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site.
1 P79063 (/TAS)
Sequence-specific mRNA binding GO:1990825
Interacting selectively and non-covalently with messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif.
1 P79063 (/EXP)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0000184
The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
55 P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS)
(45 more)
Translational termination GO:0006415
The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
55 Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO)
(45 more)
Regulation of translational termination GO:0006449
Any process that modulates the frequency, rate or extent of translational termination.
55 P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS)
(45 more)
Protein methylation GO:0006479
The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
55 P62495 (/IDA) P62495 (/IDA) P62495 (/IDA) P62495 (/IDA) P62495 (/IDA) P62495 (/IDA) P62495 (/IDA) P62495 (/IDA) P62495 (/IDA) P62495 (/IDA)
(45 more)
Protein methylation GO:0006479
The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
55 Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO)
(45 more)
Translational termination GO:0006415
The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
16 P12385 (/IGI) P12385 (/IGI) P12385 (/IGI) P12385 (/IGI) P12385 (/IGI) P12385 (/IGI) P12385 (/IGI) P12385 (/IGI) P12385 (/IGI) P12385 (/IGI)
(6 more)
Translational termination GO:0006415
The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
13 P12385 (/IMP) P12385 (/IMP) P12385 (/IMP) P12385 (/IMP) P12385 (/IMP) P12385 (/IMP) P12385 (/IMP) P12385 (/IMP) P12385 (/IMP) P12385 (/IMP)
(3 more)
Regulation of translational termination GO:0006449
Any process that modulates the frequency, rate or extent of translational termination.
12 O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS) O96203 (/ISS)
(2 more)
DNA-templated transcription, termination GO:0006353
The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA.
10 P12385 (/IMP) P12385 (/IMP) P12385 (/IMP) P12385 (/IMP) P12385 (/IMP) P12385 (/IMP) P12385 (/IMP) P12385 (/IMP) P12385 (/IMP) P12385 (/IMP)
Translational termination GO:0006415
The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
10 P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA)
Translational termination GO:0006415
The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
10 P12385 (/TAS) P12385 (/TAS) P12385 (/TAS) P12385 (/TAS) P12385 (/TAS) P12385 (/TAS) P12385 (/TAS) P12385 (/TAS) P12385 (/TAS) P12385 (/TAS)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
2 A0A2R8QI78 (/IMP) Q803E5 (/IMP)
Cytoplasmic translational termination GO:0002184
The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon.
1 P79063 (/IPI)
Asexual sporulation resulting in formation of a cellular spore GO:0043936
The formation of a cellular spore derived from the products of mitosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.
1 C8V9C7 (/IMP)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
279 P35615 (/ISS) P35615 (/ISS) P62496 (/ISS) P62496 (/ISS) P62496 (/ISS) P62496 (/ISS) P62496 (/ISS) P62496 (/ISS) P62496 (/ISS) P62496 (/ISS)
(269 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
65 P12385 (/TAS) P12385 (/TAS) P12385 (/TAS) P12385 (/TAS) P12385 (/TAS) P12385 (/TAS) P12385 (/TAS) P12385 (/TAS) P12385 (/TAS) P12385 (/TAS)
(55 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
55 P62495 (/IDA) P62495 (/IDA) P62495 (/IDA) P62495 (/IDA) P62495 (/IDA) P62495 (/IDA) P62495 (/IDA) P62495 (/IDA) P62495 (/IDA) P62495 (/IDA)
(45 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
55 Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO) Q8BWY3 (/ISO)
(45 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
55 P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS) P62495 (/TAS)
(45 more)
Translation release factor complex GO:0018444
A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome.
11 P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA)
(1 more)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
10 P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA) P12385 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9LPV8 (/IDA) Q9LPV8 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q9LPV8 (/IDA) Q9LPV8 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P79063 (/HDA)
Translation release factor complex GO:0018444
A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome.
1 P79063 (/IMP)
Translation release factor complex GO:0018444
A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome.
1 P79063 (/IPI)
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