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CATH Superfamily 3.30.420.310

2-keto-3-deoxy-galactonokinase, C-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
2-keto-3-deoxy-galactonokinase, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: 2-keto-3-deoxy-galactonokinase, C-terminal domain

According to the literature, members of the structural domains which comprise this superfamily correspond to the structure of the C-terminal domain of 2-keto-3-deoxy-galactonokinase. This is a bacterial transferase which catalyses the penultimate reaction in the Ley-Doudoroff pathway, where d-galactose is metabolized into pyruvate and d- glyceraldehyde 3-phosphate. This reaction involves the phosphorylation of 2-oxo-3-deoxygalactonate to 2-oxo-3-deoxygalactonate 6-phosphate using ATP as a phosphoryl-group donor.

Structure determination of this enzyme has revealed the presence of a nucleotide biding site, and therefore the involvement of this domain in nucleotide binding PMID:21795809

GO Diversity

Unique GO annotations
4 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
2200 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 10
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 3
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 3
Function
Unique EC: 1
Unique GO: 4
Taxonomy
Unique Species: 2200
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