The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Zinc/RING finger domain, C3HC4 (zinc finger)
".
FunFam 72: lysine-specific demethylase 5C isoform X2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 13 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Histone demethylase activity (H3-K4 specific) GO:0032453
Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein.
|
4 | A6N6J7 (/IDA) P41229 (/IDA) Q9BY66 (/IDA) Q9BY66 (/IDA) |
|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
3 | P41229 (/ISA) Q9BY66 (/ISA) Q9BY66 (/ISA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | P41229 (/IPI) Q9BY66 (/IPI) Q9BY66 (/IPI) |
|
Histone demethylase activity (H3-K4 specific) GO:0032453
Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein.
|
2 | P41230 (/ISO) Q62240 (/ISO) |
|
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
|
2 | Q9BY66 (/IDA) Q9BY66 (/IDA) |
|
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
|
1 | A6N6J7 (/IDA) |
|
RNA polymerase II transcription factor binding GO:0001085
Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.
|
1 | P41230 (/ISO) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | P41229 (/IDA) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | P41230 (/ISO) |
|
Histone demethylase activity (H3-K4 specific) GO:0032453
Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein.
|
1 | P41229 (/IMP) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | A6N6J7 (/IDA) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | P41230 (/ISO) |
|
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
|
1 | Q62240 (/ISO) |
There are 13 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Histone H3-K4 demethylation GO:0034720
The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone.
|
5 | A6N6J7 (/IDA) P41229 (/IDA) P41230 (/IDA) Q9BY66 (/IDA) Q9BY66 (/IDA) |
|
Histone H3-K4 demethylation GO:0034720
The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone.
|
2 | P41230 (/ISO) Q62240 (/ISO) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P41229 (/ISS) Q38JA7 (/ISS) |
|
Regulation of androgen receptor signaling pathway GO:0060765
Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway.
|
2 | Q9BY66 (/IMP) Q9BY66 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | A6N6J7 (/IGI) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | P41230 (/ISO) |
|
T cell antigen processing and presentation GO:0002457
The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
|
1 | Q62240 (/IDA) |
|
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
|
1 | V9GW19 (/IEP) |
|
Histone H3-K4 demethylation GO:0034720
The modification of histone H3 by the removal of a methyl group from lysine at position 4 of the histone.
|
1 | P41229 (/IMP) |
|
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
1 | P41230 (/NAS) |
|
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
|
1 | B0S6L0 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P41230 (/IDA) |
|
Regulation of androgen receptor signaling pathway GO:0060765
Any process that modulates the rate, frequency, or extent of the androgen receptor signaling pathway.
|
1 | Q62240 (/ISO) |
There are 11 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
|
3 | E9PFH2 (/IDA) Q9BY66 (/IDA) Q9BY66 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | P41229 (/TAS) Q9BY66 (/TAS) Q9BY66 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P41229 (/IDA) P41230 (/IDA) |
|
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
|
1 | Q62240 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P41230 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | P41229 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | P41230 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | A6N6J7 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P41230 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P41229 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P41230 (/ISO) |
