The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Zinc/RING finger domain, C3HC4 (zinc finger)
".
FunFam 53: protein AF-10 isoform X2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 13 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
7 | A0A0B4KFD2 (/IMP) A0A0B4KGB4 (/IMP) A0A0B4KGP1 (/IMP) Q7KSZ0 (/IMP) Q7YU77 (/IMP) Q962D1 (/IMP) Q9VI63 (/IMP) |
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
7 | A0A0B4KFD2 (/ISS) A0A0B4KGB4 (/ISS) A0A0B4KGP1 (/ISS) Q7KSZ0 (/ISS) Q7YU77 (/ISS) Q962D1 (/ISS) Q9VI63 (/ISS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | O54826 (/IPI) P55197 (/IPI) P55198 (/IPI) P55198 (/IPI) Q6P2C6 (/IPI) |
Nucleosome binding GO:0031491
Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
|
4 | B1AR09 (/ISO) B1AR10 (/ISO) O54826 (/ISO) Q8VHB4 (/ISO) |
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
4 | B1AR09 (/ISO) B1AR10 (/ISO) O54826 (/ISO) Q8VHB4 (/ISO) |
Nucleosome binding GO:0031491
Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
|
3 | P55197 (/IDA) P55198 (/IDA) P55198 (/IDA) |
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
3 | P55197 (/IPI) P55198 (/IPI) P55198 (/IPI) |
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
2 | P34447 (/IDA) P55197 (/IDA) |
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
2 | O54826 (/ISS) P34447 (/ISS) |
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
1 | O54826 (/ISO) |
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
1 | P55197 (/NAS) |
Nucleosome binding GO:0031491
Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
|
1 | O54826 (/ISS) |
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
|
1 | P34447 (/IDA) |
There are 21 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cellular homeostasis GO:0019725
Any process involved in the maintenance of an internal steady state at the level of the cell.
|
8 | A0A286YAM6 (/IMP) A0A2R8QE63 (/IMP) A0A2R8RZV0 (/IMP) E7F6V1 (/IMP) F1RE24 (/IMP) F8W2W1 (/IMP) F8W451 (/IMP) Q5U394 (/IMP) |
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
|
8 | A0A286YAM6 (/IMP) A0A2R8QE63 (/IMP) A0A2R8RZV0 (/IMP) E7F6V1 (/IMP) F1RE24 (/IMP) F8W2W1 (/IMP) F8W451 (/IMP) Q5U394 (/IMP) |
Intestinal epithelial structure maintenance GO:0060729
A tissue homeostatic process required for the maintenance of the structure of the intestinal epithelium.
|
8 | A0A286YAM6 (/IMP) A0A2R8QE63 (/IMP) A0A2R8RZV0 (/IMP) E7F6V1 (/IMP) F1RE24 (/IMP) F8W2W1 (/IMP) F8W451 (/IMP) Q5U394 (/IMP) |
Instar larval development GO:0002168
The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster.
|
7 | A0A0B4KFD2 (/IMP) A0A0B4KGB4 (/IMP) A0A0B4KGP1 (/IMP) Q7KSZ0 (/IMP) Q7YU77 (/IMP) Q962D1 (/IMP) Q9VI63 (/IMP) |
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
7 | A0A0B4KFD2 (/IMP) A0A0B4KGB4 (/IMP) A0A0B4KGP1 (/IMP) Q7KSZ0 (/IMP) Q7YU77 (/IMP) Q962D1 (/IMP) Q9VI63 (/IMP) |
Haltere development GO:0007482
The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings.
|
7 | A0A0B4KFD2 (/IGI) A0A0B4KGB4 (/IGI) A0A0B4KGP1 (/IGI) Q7KSZ0 (/IGI) Q7YU77 (/IGI) Q962D1 (/IGI) Q9VI63 (/IGI) |
Larval somatic muscle development GO:0007526
The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure.
|
7 | A0A0B4KFD2 (/IEP) A0A0B4KGB4 (/IEP) A0A0B4KGP1 (/IEP) Q7KSZ0 (/IEP) Q7YU77 (/IEP) Q962D1 (/IEP) Q9VI63 (/IEP) |
Larval somatic muscle development GO:0007526
The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure.
|
7 | A0A0B4KFD2 (/IMP) A0A0B4KGB4 (/IMP) A0A0B4KGP1 (/IMP) Q7KSZ0 (/IMP) Q7YU77 (/IMP) Q962D1 (/IMP) Q9VI63 (/IMP) |
Molting cycle, chitin-based cuticle GO:0007591
The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster.
|
7 | A0A0B4KFD2 (/IMP) A0A0B4KGB4 (/IMP) A0A0B4KGP1 (/IMP) Q7KSZ0 (/IMP) Q7YU77 (/IMP) Q962D1 (/IMP) Q9VI63 (/IMP) |
Renal system process GO:0003014
A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila).
|
3 | B1AR09 (/IMP) B1AR10 (/IMP) Q8VHB4 (/IMP) |
Excretion GO:0007588
The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.
|
3 | B1AR09 (/IMP) B1AR10 (/IMP) Q8VHB4 (/IMP) |
Positive regulation of sodium ion transport GO:0010765
Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
3 | B1AR09 (/IMP) B1AR10 (/IMP) Q8VHB4 (/IMP) |
Negative regulation of urine volume GO:0035811
Any process that decreases the amount of urine excreted from the body over a unit of time.
|
3 | B1AR09 (/IMP) B1AR10 (/IMP) Q8VHB4 (/IMP) |
Renal sodium excretion GO:0035812
The elimination by an organism of sodium in the urine.
|
3 | B1AR09 (/IMP) B1AR10 (/IMP) Q8VHB4 (/IMP) |
Renal potassium excretion GO:0036359
The elimination by an organism of potassium in the urine.
|
3 | B1AR09 (/IMP) B1AR10 (/IMP) Q8VHB4 (/IMP) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
3 | B1AR09 (/IMP) B1AR10 (/IMP) Q8VHB4 (/IMP) |
Negative regulation of histone H3-K79 methylation GO:2001161
Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K79 methylation.
|
3 | B1AR09 (/IMP) B1AR10 (/IMP) Q8VHB4 (/IMP) |
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | P55198 (/TAS) P55198 (/TAS) |
RNA interference GO:0016246
The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.
|
1 | P34447 (/IMP) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | P55197 (/IDA) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | O54826 (/ISO) |
There are 11 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
9 | A0A0B4KFD2 (/IDA) A0A0B4KGB4 (/IDA) A0A0B4KGP1 (/IDA) P34447 (/IDA) P55197 (/IDA) Q7KSZ0 (/IDA) Q7YU77 (/IDA) Q962D1 (/IDA) Q9VI63 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
7 | A0A0B4KFD2 (/ISS) A0A0B4KGB4 (/ISS) A0A0B4KGP1 (/ISS) Q7KSZ0 (/ISS) Q7YU77 (/ISS) Q962D1 (/ISS) Q9VI63 (/ISS) |
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
|
1 | P34447 (/ISS) |
Condensed chromosome GO:0000793
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.
|
1 | P34447 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O54826 (/ISO) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | P55197 (/IDA) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | O54826 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P55197 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O54826 (/ISO) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | P55197 (/IDA) |
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | O54826 (/ISO) |