The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Zinc/RING finger domain, C3HC4 (zinc finger)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 487: tripartite motif-containing protein 72

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
6 A0JPQ4 (/ISS) Q1XH18 (/ISS) Q640S6 (/ISS) Q6PGR9 (/ISS) Q6ZMU5 (/ISS) Q6ZMU5 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q1XH17 (/IPI) Q6ZMU5 (/IPI) Q6ZMU5 (/IPI)
Phosphatidylserine binding GO:0001786
Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
1 Q1XH17 (/IDA)
Ubiquitin conjugating enzyme binding GO:0031624
Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins.
1 Q1XH17 (/IDA)
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
1 Q1XH17 (/IMP)

There are 15 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane repair GO:0001778
The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress.
6 A0JPQ4 (/ISS) Q1XH18 (/ISS) Q640S6 (/ISS) Q6PGR9 (/ISS) Q6ZMU5 (/ISS) Q6ZMU5 (/ISS)
Muscle system process GO:0003012
A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.
6 A0JPQ4 (/ISS) Q1XH18 (/ISS) Q640S6 (/ISS) Q6PGR9 (/ISS) Q6ZMU5 (/ISS) Q6ZMU5 (/ISS)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
6 A0JPQ4 (/ISS) Q1XH18 (/ISS) Q640S6 (/ISS) Q6PGR9 (/ISS) Q6ZMU5 (/ISS) Q6ZMU5 (/ISS)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
6 A0JPQ4 (/ISS) Q1XH18 (/ISS) Q640S6 (/ISS) Q6PGR9 (/ISS) Q6ZMU5 (/ISS) Q6ZMU5 (/ISS)
Muscle contraction GO:0006936
A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
2 Q6ZMU5 (/TAS) Q6ZMU5 (/TAS)
Plasma membrane repair GO:0001778
The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress.
1 Q1XH17 (/IMP)
Muscle system process GO:0003012
A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.
1 Q1XH17 (/IMP)
Exocytosis GO:0006887
A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
1 Q1XH17 (/TAS)
Vesicle budding from membrane GO:0006900
The evagination of a membrane, resulting in formation of a vesicle.
1 Q1XH17 (/TAS)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
1 Q1XH17 (/IMP)
Negative regulation of myotube differentiation GO:0010832
Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
1 Q1XH17 (/IDA)
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
1 Q1XH17 (/IMP)
Negative regulation of insulin-like growth factor receptor signaling pathway GO:0043569
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling.
1 Q1XH17 (/IGI)
Negative regulation of insulin receptor signaling pathway GO:0046627
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
1 Q1XH17 (/IDA)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 Q1XH17 (/IPI)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasmic vesicle membrane GO:0030659
The lipid bilayer surrounding a cytoplasmic vesicle.
6 A0JPQ4 (/ISS) Q1XH18 (/ISS) Q640S6 (/ISS) Q6PGR9 (/ISS) Q6ZMU5 (/ISS) Q6ZMU5 (/ISS)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
6 A0JPQ4 (/ISS) Q1XH18 (/ISS) Q640S6 (/ISS) Q6PGR9 (/ISS) Q6ZMU5 (/ISS) Q6ZMU5 (/ISS)
Cytoplasmic vesicle membrane GO:0030659
The lipid bilayer surrounding a cytoplasmic vesicle.
3 Q1XH17 (/TAS) Q6ZMU5 (/TAS) Q6ZMU5 (/TAS)
Cytoplasmic vesicle membrane GO:0030659
The lipid bilayer surrounding a cytoplasmic vesicle.
1 Q1XH17 (/IDA)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
1 Q1XH17 (/IDA)
CATH-Gene3D is a Global Biodata Core Resource Learn more...