The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Zinc/RING finger domain, C3HC4 (zinc finger)
".
FunFam 40: E3 ubiquitin protein ligase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 30 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
16 |
O75150 (/IPI)
P34537 (/IPI)
Q3U319 (/IPI)
Q5DTM8 (/IPI)
Q5VTR2 (/IPI)
Q5VTR2 (/IPI)
Q5VTR2 (/IPI)
Q5VTR2 (/IPI)
Q5VTR2 (/IPI)
Q5VTR2 (/IPI)
(6 more) |
|
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
|
12 |
O75150 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
(2 more) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
12 |
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
(2 more) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
12 |
O75150 (/IPI)
Q5VTR2 (/IPI)
Q5VTR2 (/IPI)
Q5VTR2 (/IPI)
Q5VTR2 (/IPI)
Q5VTR2 (/IPI)
Q5VTR2 (/IPI)
Q5VTR2 (/IPI)
Q5VTR2 (/IPI)
Q5VTR2 (/IPI)
(2 more) |
|
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
|
11 |
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
(1 more) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
11 |
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
(1 more) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
11 |
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
(1 more) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
3 | A2VDP1 (/ISS) Q4R7K7 (/ISS) Q5RAU7 (/ISS) |
|
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
|
2 | Q3U319 (/ISO) Q5DTM8 (/ISO) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
2 | Q3U319 (/ISO) Q5DTM8 (/ISO) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
2 | Q9VRP9 (/ISS) Q9VRP9 (/ISS) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
2 | Q9VRP9 (/ISM) Q9VRP9 (/ISM) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
2 | Q3U319 (/ISO) Q5DTM8 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | Q4R7K7 (/ISS) Q5RAU7 (/ISS) |
|
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
|
1 | Q5DTM8 (/ISO) |
|
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
|
1 | A2VDP1 (/ISS) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
1 | Q5DTM8 (/IDA) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | Q5DTM8 (/ISO) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | A2VDP1 (/ISS) |
|
Syntaxin-1 binding GO:0017075
Interacting selectively and non-covalently with the SNAP receptor syntaxin-1.
|
1 | Q8CJB9 (/IPI) |
|
Syntaxin-1 binding GO:0017075
Interacting selectively and non-covalently with the SNAP receptor syntaxin-1.
|
1 | Q3U319 (/ISO) |
|
Ubiquitin conjugating enzyme binding GO:0031624
Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins.
|
1 | Q8CJB9 (/IDA) |
|
Ubiquitin conjugating enzyme binding GO:0031624
Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins.
|
1 | P34537 (/IPI) |
|
Ubiquitin conjugating enzyme binding GO:0031624
Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins.
|
1 | Q3U319 (/ISO) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
1 | Q5DTM8 (/ISO) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
1 | A2VDP1 (/ISS) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | O75150 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | Q3U319 (/ISO) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | Q8CJB9 (/IDA) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | Q3U319 (/ISO) |
There are 38 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of histone H2B ubiquitination GO:2001168
Any process that activates or increases the frequency, rate or extent of histone H2B ubiquitination.
|
13 |
O75150 (/IMP)
Q3U319 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
(3 more) |
|
Histone monoubiquitination GO:0010390
The modification of histones by addition of a single ubiquitin group.
|
12 |
O75150 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
(2 more) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
12 |
O75150 (/TAS)
Q5VTR2 (/TAS)
Q5VTR2 (/TAS)
Q5VTR2 (/TAS)
Q5VTR2 (/TAS)
Q5VTR2 (/TAS)
Q5VTR2 (/TAS)
Q5VTR2 (/TAS)
Q5VTR2 (/TAS)
Q5VTR2 (/TAS)
(2 more) |
|
Histone H2B ubiquitination GO:0033523
The modification of histone H2B by addition of ubiquitin groups.
|
12 |
O75150 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
(2 more) |
|
Negative regulation of mRNA polyadenylation GO:1900364
Any process that stops, prevents or reduces the frequency, rate or extent of mRNA polyadenylation.
|
12 |
O75150 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
(2 more) |
|
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
11 |
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
(1 more) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
11 |
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
(1 more) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
11 |
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
(1 more) |
|
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
|
11 |
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
(1 more) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
11 |
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
Q5VTR2 (/IMP)
(1 more) |
|
Histone monoubiquitination GO:0010390
The modification of histones by addition of a single ubiquitin group.
|
3 | A2VDP1 (/ISS) Q4R7K7 (/ISS) Q5RAU7 (/ISS) |
|
Histone ubiquitination GO:0016574
The modification of histones by addition of ubiquitin groups.
|
3 | Q5DTM8 (/IMP) Q9VRP9 (/IMP) Q9VRP9 (/IMP) |
|
Histone H2B ubiquitination GO:0033523
The modification of histone H2B by addition of ubiquitin groups.
|
3 | A2VDP1 (/ISS) Q4R7K7 (/ISS) Q5RAU7 (/ISS) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
2 | Q3U319 (/ISO) Q5DTM8 (/ISO) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
2 | A2VDP1 (/ISS) O75150 (/ISS) |
|
Protein monoubiquitination GO:0006513
Addition of a single ubiquitin group to a protein.
|
2 | Q9VRP9 (/IMP) Q9VRP9 (/IMP) |
|
Histone monoubiquitination GO:0010390
The modification of histones by addition of a single ubiquitin group.
|
2 | Q3U319 (/ISO) Q5DTM8 (/ISO) |
|
Histone modification GO:0016570
The covalent alteration of one or more amino acid residues within a histone protein.
|
2 | Q9VRP9 (/IMP) Q9VRP9 (/IMP) |
|
Histone ubiquitination GO:0016574
The modification of histones by addition of ubiquitin groups.
|
2 | Q9VRP9 (/ISS) Q9VRP9 (/ISS) |
|
Histone H2B ubiquitination GO:0033523
The modification of histone H2B by addition of ubiquitin groups.
|
2 | Q3U319 (/ISO) Q5DTM8 (/ISO) |
|
Negative regulation of mRNA polyadenylation GO:1900364
Any process that stops, prevents or reduces the frequency, rate or extent of mRNA polyadenylation.
|
2 | Q3U319 (/ISO) Q5DTM8 (/ISO) |
|
Positive regulation of histone H2B ubiquitination GO:2001168
Any process that activates or increases the frequency, rate or extent of histone H2B ubiquitination.
|
2 | Q3U319 (/ISO) Q5DTM8 (/ISO) |
|
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
1 | Q5DTM8 (/ISO) |
|
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
1 | A2VDP1 (/ISS) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q5DTM8 (/ISO) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | A2VDP1 (/ISS) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
1 | Q8CJB9 (/IDA) |
|
Glycolipid metabolic process GO:0006664
The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent.
|
1 | P34537 (/IMP) |
|
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
|
1 | Q5DTM8 (/ISO) |
|
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
|
1 | A2VDP1 (/ISS) |
|
Positive regulation of histone methylation GO:0031062
Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones.
|
1 | Q5DTM8 (/IMP) |
|
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
|
1 | Q8CJB9 (/IEP) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q5DTM8 (/ISO) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | A2VDP1 (/ISS) |
|
Positive regulation of proteasomal protein catabolic process GO:1901800
Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process.
|
1 | Q8CJB9 (/IDA) |
|
Positive regulation of proteasomal protein catabolic process GO:1901800
Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process.
|
1 | Q3U319 (/ISO) |
|
Positive regulation of protein polyubiquitination GO:1902916
Any process that activates or increases the frequency, rate or extent of protein polyubiquitination.
|
1 | Q8CJB9 (/IDA) |
|
Positive regulation of protein polyubiquitination GO:1902916
Any process that activates or increases the frequency, rate or extent of protein polyubiquitination.
|
1 | Q3U319 (/ISO) |
There are 27 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
15 |
O75150 (/IDA)
P34537 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
(5 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
13 |
H3BP71 (/IDA)
O75150 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
(3 more) |
|
Ubiquitin ligase complex GO:0000151
A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
|
12 |
O75150 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
(2 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
12 |
O75150 (/TAS)
Q5VTR2 (/TAS)
Q5VTR2 (/TAS)
Q5VTR2 (/TAS)
Q5VTR2 (/TAS)
Q5VTR2 (/TAS)
Q5VTR2 (/TAS)
Q5VTR2 (/TAS)
Q5VTR2 (/TAS)
Q5VTR2 (/TAS)
(2 more) |
|
HULC complex GO:0033503
A ubiquitin-conjugating enzyme complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp1, Brl2/Rfp1 and Brl1/Rfp2.
|
12 |
O75150 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
(2 more) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
11 |
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
Q5VTR2 (/IDA)
(1 more) |
|
HULC complex GO:0033503
A ubiquitin-conjugating enzyme complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp1, Brl2/Rfp1 and Brl1/Rfp2.
|
7 | A2VDP1 (/ISS) Q3U319 (/ISS) Q4R7K7 (/ISS) Q5DTM8 (/ISS) Q5RAU7 (/ISS) Q5ZLS3 (/ISS) Q8CJB9 (/ISS) |
|
Ubiquitin ligase complex GO:0000151
A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
|
3 | A2VDP1 (/ISS) Q4R7K7 (/ISS) Q5RAU7 (/ISS) |
|
Ubiquitin ligase complex GO:0000151
A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
|
2 | Q3U319 (/ISO) Q5DTM8 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q3U319 (/ISO) Q5DTM8 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q4R7K7 (/ISS) Q5RAU7 (/ISS) |
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Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
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2 | Q3U319 (/ISO) Q5DTM8 (/ISO) |
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HULC complex GO:0033503
A ubiquitin-conjugating enzyme complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp1, Brl2/Rfp1 and Brl1/Rfp2.
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2 | Q3U319 (/ISO) Q5DTM8 (/ISO) |
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Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
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1 | Q5DTM8 (/ISO) |
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Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
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1 | A2VDP1 (/ISS) |
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Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
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1 | Q8CJB9 (/IDA) |
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Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
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1 | Q3U319 (/ISO) |
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Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
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1 | O75150 (/HDA) |
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Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
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1 | Q8CJB9 (/IDA) |
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Extrinsic component of membrane GO:0019898
The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
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1 | Q3U319 (/ISO) |
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Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
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1 | Q8CJB9 (/IDA) |
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Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
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1 | Q3U319 (/ISO) |
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Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
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1 | Q8CJB9 (/IDA) |
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Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
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1 | Q3U319 (/ISO) |
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Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
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1 | O75150 (/ISS) |
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Axon terminus GO:0043679
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
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1 | Q8CJB9 (/IDA) |
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Axon terminus GO:0043679
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
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1 | Q3U319 (/ISO) |
