The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Zinc/RING finger domain, C3HC4 (zinc finger)
".
FunFam 4: Jade family PHD finger 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
7 | Q6IE81 (/IPI) Q6IE81 (/IPI) Q6IE81 (/IPI) Q6ZQF7 (/IPI) Q92613 (/IPI) Q92613 (/IPI) Q9NQC1 (/IPI) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
3 | Q6IE81 (/IDA) Q6IE81 (/IDA) Q6IE81 (/IDA) |
|
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes.
|
2 | Q12311 (/IDA) Q12311 (/IDA) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
1 | Q6ZPI0 (/ISO) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | O74759 (/ISM) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
1 | A0A0G2L9X9 (/IMP) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
1 | Q6ZQF7 (/IDA) |
|
Ubiquitin-like protein ligase activity GO:0061659
Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S --> X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate.
|
1 | O74759 (/ISM) |
There are 36 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Histone H3 acetylation GO:0043966
The modification of histone H3 by the addition of an acetyl group.
|
6 | Q6IE81 (/IDA) Q6IE81 (/IDA) Q6IE81 (/IDA) Q92613 (/IDA) Q92613 (/IDA) Q9NQC1 (/IDA) |
|
Histone H4-K5 acetylation GO:0043981
The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone.
|
6 | Q6IE81 (/IDA) Q6IE81 (/IDA) Q6IE81 (/IDA) Q92613 (/IDA) Q92613 (/IDA) Q9NQC1 (/IDA) |
|
Histone H4-K8 acetylation GO:0043982
The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone.
|
6 | Q6IE81 (/IDA) Q6IE81 (/IDA) Q6IE81 (/IDA) Q92613 (/IDA) Q92613 (/IDA) Q9NQC1 (/IDA) |
|
Histone H4-K12 acetylation GO:0043983
The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone.
|
6 | Q6IE81 (/IDA) Q6IE81 (/IDA) Q6IE81 (/IDA) Q92613 (/IDA) Q92613 (/IDA) Q9NQC1 (/IDA) |
|
Histone H3 acetylation GO:0043966
The modification of histone H3 by the addition of an acetyl group.
|
5 | A0A3B2WCP8 (/ISO) A0A3B2WD38 (/ISO) Q6IE82 (/ISO) Q6ZPI0 (/ISO) Q6ZQF7 (/ISO) |
|
Histone H3 acetylation GO:0043966
The modification of histone H3 by the addition of an acetyl group.
|
4 | Q5E9T7 (/ISS) Q6IE82 (/ISS) Q6ZPI0 (/ISS) Q6ZQF7 (/ISS) |
|
Histone H4-K5 acetylation GO:0043981
The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone.
|
4 | Q5E9T7 (/ISS) Q6IE82 (/ISS) Q6ZPI0 (/ISS) Q6ZQF7 (/ISS) |
|
Histone H4-K8 acetylation GO:0043982
The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone.
|
4 | Q5E9T7 (/ISS) Q6IE82 (/ISS) Q6ZPI0 (/ISS) Q6ZQF7 (/ISS) |
|
Histone H4-K12 acetylation GO:0043983
The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone.
|
4 | Q5E9T7 (/ISS) Q6IE82 (/ISS) Q6ZPI0 (/ISS) Q6ZQF7 (/ISS) |
|
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
|
3 | Q6IE81 (/NAS) Q6IE81 (/NAS) Q6IE81 (/NAS) |
|
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
|
3 | Q6IE81 (/NAS) Q6IE81 (/NAS) Q6IE81 (/NAS) |
|
Histone H4-K5 acetylation GO:0043981
The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone.
|
3 | Q6IE82 (/ISO) Q6ZPI0 (/ISO) Q6ZQF7 (/ISO) |
|
Histone H4-K8 acetylation GO:0043982
The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone.
|
3 | Q6IE82 (/ISO) Q6ZPI0 (/ISO) Q6ZQF7 (/ISO) |
|
Histone H4-K12 acetylation GO:0043983
The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone.
|
3 | Q6IE82 (/ISO) Q6ZPI0 (/ISO) Q6ZQF7 (/ISO) |
|
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
3 | Q6IE81 (/IDA) Q6IE81 (/IDA) Q6IE81 (/IDA) |
|
Negative regulation of G1/S transition of mitotic cell cycle GO:2000134
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
|
3 | Q6IE81 (/IDA) Q6IE81 (/IDA) Q6IE81 (/IDA) |
|
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
|
2 | Q12311 (/IPI) Q12311 (/IPI) |
|
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
1 | Q6ZQF7 (/IDA) |
|
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
1 | Q6ZQF7 (/IMP) |
|
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
|
1 | A0A0G2L9X9 (/IGI) |
|
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
|
1 | A0A0G2L9X9 (/IMP) |
|
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
|
1 | O74759 (/IC) |
|
Compound eye photoreceptor development GO:0042051
The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure.
|
1 | Q7YZH1 (/IMP) |
|
Compound eye photoreceptor development GO:0042051
The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure.
|
1 | Q29EQ3 (/ISS) |
|
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
|
1 | Q7YZH1 (/IMP) |
|
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
|
1 | Q29EQ3 (/ISS) |
|
Regulation of neurogenesis GO:0050767
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
|
1 | Q6ZQF7 (/IGI) |
|
Positive regulation of neurogenesis GO:0050769
Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
|
1 | Q6ZQF7 (/IDA) |
|
Positive regulation of neurogenesis GO:0050769
Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.
|
1 | Q6ZQF7 (/IMP) |
|
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
1 | Q6ZQF7 (/IDA) |
|
SMAD protein signal transduction GO:0060395
The cascade of processes by which a signal interacts with a receptor, causing a change in the activity of a SMAD protein, and ultimately effecting a change in the functioning of the cell.
|
1 | Q6ZQF7 (/IDA) |
|
Regulation of canonical Wnt signaling pathway GO:0060828
Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
1 | Q803A0 (/IGI) |
|
Protein modification by small protein conjugation or removal GO:0070647
A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to or removed from a target protein.
|
1 | O74759 (/IC) |
|
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
1 | Q6ZPI0 (/ISO) |
|
Neuron projection extension GO:1990138
Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
|
1 | Q6ZQF7 (/IGI) |
|
Negative regulation of G1/S transition of mitotic cell cycle GO:2000134
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
|
1 | Q6ZPI0 (/ISO) |
There are 28 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Histone acetyltransferase complex GO:0000123
A protein complex that possesses histone acetyltransferase activity.
|
6 | Q6IE81 (/IDA) Q6IE81 (/IDA) Q6IE81 (/IDA) Q92613 (/IDA) Q92613 (/IDA) Q9NQC1 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | Q6IE81 (/IDA) Q6IE81 (/IDA) Q6IE81 (/IDA) Q7YZH1 (/IDA) |
|
Histone acetyltransferase complex GO:0000123
A protein complex that possesses histone acetyltransferase activity.
|
3 | Q6IE82 (/ISO) Q6ZPI0 (/ISO) Q6ZQF7 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | A0A0C4DFT8 (/IDA) G3XAA4 (/IDA) Q9NQC1 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | Q6IE81 (/TAS) Q6IE81 (/TAS) Q6IE81 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | O74759 (/HDA) Q12311 (/HDA) Q12311 (/HDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | Q6IE81 (/IDA) Q6IE81 (/IDA) Q6IE81 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | Q6IE81 (/IDA) Q6IE81 (/IDA) Q6IE81 (/IDA) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
3 | Q6IE81 (/IDA) Q6IE81 (/IDA) Q6IE81 (/IDA) |
|
Ciliary basal body GO:0036064
A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
|
3 | Q6IE81 (/IDA) Q6IE81 (/IDA) Q6IE81 (/IDA) |
|
Histone acetyltransferase complex GO:0000123
A protein complex that possesses histone acetyltransferase activity.
|
2 | Q5E9T7 (/ISS) Q6ZPI0 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q12311 (/HDA) Q12311 (/HDA) |
|
NuA3 histone acetyltransferase complex GO:0033100
A Gcn5-independent multisubunit complex that catalyzes the acetylation of histone H3. The budding yeast complex includes Sas3p, Taf30p, and Yng1p.
|
2 | Q12311 (/IDA) Q12311 (/IDA) |
|
MOZ/MORF histone acetyltransferase complex GO:0070776
A histone acetyltransferase complex that has histone H3 acetyltransferase and coactivator activities. Subunits of the human complex include MYST3/MOZ, MYST4/MORF, ING5, EAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.
|
2 | A0A3B2WCP8 (/ISO) A0A3B2WD38 (/ISO) |
|
NuA3a histone acetyltransferase complex GO:1990467
A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Yng1p and associates with H3K4me3 using Yng1p.
|
2 | Q12311 (/IDA) Q12311 (/IDA) |
|
NuA3b histone acetyltransferase complex GO:1990468
A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Pdp3 and associates with H3K4me3 via Pdp3p.
|
2 | Q12311 (/IDA) Q12311 (/IDA) |
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
1 | A0A0G2L9X9 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q6ZPI0 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q29EQ3 (/ISS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q6ZQF7 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q6ZPI0 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q6ZPI0 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q6ZPI0 (/ISO) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
1 | Q6ZPI0 (/ISO) |
|
NuA3 histone acetyltransferase complex GO:0033100
A Gcn5-independent multisubunit complex that catalyzes the acetylation of histone H3. The budding yeast complex includes Sas3p, Taf30p, and Yng1p.
|
1 | O74759 (/ISO) |
|
Ciliary basal body GO:0036064
A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
|
1 | Q6ZPI0 (/ISO) |
|
Mst2 histone acetyltransferase complex GO:0036410
A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3, and contains Mst2 as the catalytic subunit. In fission yeast, contains at least Mst2, Nto1, Ptf2, Ptf1 and Eaf6.
|
1 | O74759 (/TAS) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q9NQC1 (/HDA) |
