The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Zinc/RING finger domain, C3HC4 (zinc finger)
".
FunFam 235: E3 ubiquitin-protein ligase ZNRF1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
14 |
F1MM41 (/ISS)
F7EP40 (/ISS)
Q66KG7 (/ISS)
Q66KG7 (/ISS)
Q6P4U6 (/ISS)
Q6P4U6 (/ISS)
Q8ND25 (/ISS)
Q8ND25 (/ISS)
Q8ND25 (/ISS)
Q8ND25 (/ISS)
(4 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
8 | Q8ND25 (/IPI) Q8ND25 (/IPI) Q8ND25 (/IPI) Q8ND25 (/IPI) Q8ND25 (/IPI) Q8ND25 (/IPI) Q8ND25 (/IPI) Q91V17 (/IPI) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
8 | Q8ND25 (/IDA) Q8ND25 (/IDA) Q8ND25 (/IDA) Q8ND25 (/IDA) Q8ND25 (/IDA) Q8ND25 (/IDA) Q8ND25 (/IDA) Q91V17 (/IDA) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | Q91V17 (/IDA) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | Q9W3V3 (/ISM) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
1 | Q91V17 (/ISO) |
There are 7 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
13 |
F1MM41 (/ISS)
F7EP40 (/ISS)
Q66KG7 (/ISS)
Q66KG7 (/ISS)
Q6P4U6 (/ISS)
Q6P4U6 (/ISS)
Q8ND25 (/ISS)
Q8ND25 (/ISS)
Q8ND25 (/ISS)
Q8ND25 (/ISS)
(3 more) |
|
Protein K48-linked ubiquitination GO:0070936
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
|
13 |
F1MM41 (/ISS)
F7EP40 (/ISS)
Q66KG7 (/ISS)
Q66KG7 (/ISS)
Q6P4U6 (/ISS)
Q6P4U6 (/ISS)
Q8ND25 (/ISS)
Q8ND25 (/ISS)
Q8ND25 (/ISS)
Q8ND25 (/ISS)
(3 more) |
|
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
7 | Q8ND25 (/TAS) Q8ND25 (/TAS) Q8ND25 (/TAS) Q8ND25 (/TAS) Q8ND25 (/TAS) Q8ND25 (/TAS) Q8ND25 (/TAS) |
|
Cytoskeleton organization GO:0007010
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
|
1 | Q91V17 (/TAS) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
1 | Q9W3V3 (/ISS) |
|
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
1 | Q91V17 (/IDA) |
|
Protein K48-linked ubiquitination GO:0070936
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
|
1 | Q91V17 (/IDA) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
|
7 | Q8ND25 (/IDA) Q8ND25 (/IDA) Q8ND25 (/IDA) Q8ND25 (/IDA) Q8ND25 (/IDA) Q8ND25 (/IDA) Q8ND25 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
7 | Q8ND25 (/IDA) Q8ND25 (/IDA) Q8ND25 (/IDA) Q8ND25 (/IDA) Q8ND25 (/IDA) Q8ND25 (/IDA) Q8ND25 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
7 | Q8ND25 (/TAS) Q8ND25 (/TAS) Q8ND25 (/TAS) Q8ND25 (/TAS) Q8ND25 (/TAS) Q8ND25 (/TAS) Q8ND25 (/TAS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
7 | Q8ND25 (/IDA) Q8ND25 (/IDA) Q8ND25 (/IDA) Q8ND25 (/IDA) Q8ND25 (/IDA) Q8ND25 (/IDA) Q8ND25 (/IDA) |
|
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
|
1 | Q91V17 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q91V17 (/ISO) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q91V17 (/ISO) |
