The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Zinc/RING finger domain, C3HC4 (zinc finger)
".
FunFam 178: PML isoform 6
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 14 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | F1M589 (/IPI) P29590 (/IPI) Q15156 (/IPI) Q60953 (/IPI) Q60953 (/IPI) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
2 | Q60953 (/TAS) Q60953 (/TAS) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
SUMO binding GO:0032183
Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
|
2 | Q60953 (/IDA) Q60953 (/IDA) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Cobalt ion binding GO:0050897
Interacting selectively and non-covalently with a cobalt (Co) ion.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
1 | Q15156 (/NAS) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
1 | P29590 (/IPI) |
|
SUMO binding GO:0032183
Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO.
|
1 | P29590 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P29590 (/IPI) |
There are 106 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
14 |
Q15JD3 (/ISS)
Q15JD4 (/ISS)
Q15JD5 (/ISS)
Q15JD6 (/ISS)
Q15JD7 (/ISS)
Q15JD8 (/ISS)
Q15JD9 (/ISS)
Q15JE0 (/ISS)
Q15JE1 (/ISS)
Q15JE1 (/ISS)
(4 more) |
|
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
|
14 |
Q15JD3 (/ISS)
Q15JD4 (/ISS)
Q15JD5 (/ISS)
Q15JD6 (/ISS)
Q15JD7 (/ISS)
Q15JD8 (/ISS)
Q15JD9 (/ISS)
Q15JE0 (/ISS)
Q15JE1 (/ISS)
Q15JE1 (/ISS)
(4 more) |
|
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
|
14 |
Q15JD3 (/ISS)
Q15JD4 (/ISS)
Q15JD5 (/ISS)
Q15JD6 (/ISS)
Q15JD7 (/ISS)
Q15JD8 (/ISS)
Q15JD9 (/ISS)
Q15JE0 (/ISS)
Q15JE1 (/ISS)
Q15JE1 (/ISS)
(4 more) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
14 |
Q15JD3 (/ISS)
Q15JD4 (/ISS)
Q15JD5 (/ISS)
Q15JD6 (/ISS)
Q15JD7 (/ISS)
Q15JD8 (/ISS)
Q15JD9 (/ISS)
Q15JE0 (/ISS)
Q15JE1 (/ISS)
Q15JE1 (/ISS)
(4 more) |
|
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
|
14 |
Q15JD3 (/ISS)
Q15JD4 (/ISS)
Q15JD5 (/ISS)
Q15JD6 (/ISS)
Q15JD7 (/ISS)
Q15JD8 (/ISS)
Q15JD9 (/ISS)
Q15JE0 (/ISS)
Q15JE1 (/ISS)
Q15JE1 (/ISS)
(4 more) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
3 | P29590 (/IMP) Q60953 (/IMP) Q60953 (/IMP) |
|
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
|
3 | P29590 (/IMP) Q60953 (/IMP) Q60953 (/IMP) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
3 | P29590 (/IDA) Q60953 (/IDA) Q60953 (/IDA) |
|
Negative regulation of viral release from host cell GO:1902187
Any process that stops, prevents or reduces the frequency, rate or extent of viral release from host cell.
|
3 | P29590 (/IDA) Q60953 (/IDA) Q60953 (/IDA) |
|
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Regulation of protein phosphorylation GO:0001932
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Protein targeting GO:0006605
The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Protein targeting GO:0006605
The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.
|
2 | Q60953 (/ISS) Q60953 (/ISS) |
|
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Cell cycle arrest GO:0007050
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Cell cycle arrest GO:0007050
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Transforming growth factor beta receptor signaling pathway GO:0007179
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Common-partner SMAD protein phosphorylation GO:0007182
The process of introducing a phosphate group on to a common-partner SMAD protein. A common partner SMAD protein binds to pathway-restricted SMAD proteins forming a complex that translocates to the nucleus.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Cell aging GO:0007569
An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469).
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Response to UV GO:0009411
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Response to gamma radiation GO:0010332
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Regulation of calcium ion transport into cytosol GO:0010522
Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Fibroblast migration GO:0010761
Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Myeloid cell differentiation GO:0030099
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Regulation of cell adhesion GO:0030155
Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
PML body organization GO:0030578
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia).
|
2 | Q60953 (/IDA) Q60953 (/IDA) |
|
PML body organization GO:0030578
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia).
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Positive regulation of histone deacetylation GO:0031065
Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Positive regulation of histone deacetylation GO:0031065
Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones.
|
2 | Q60953 (/ISS) Q60953 (/ISS) |
|
Positive regulation of telomere maintenance GO:0032206
Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Negative regulation of telomere maintenance via telomerase GO:0032211
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Endoplasmic reticulum calcium ion homeostasis GO:0032469
Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
2 | Q60953 (/IDA) Q60953 (/IDA) |
|
Negative regulation of translation in response to oxidative stress GO:0032938
Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
2 | Q60953 (/IDA) Q60953 (/IDA) |
|
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Entrainment of circadian clock by photoperiod GO:0043153
The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
|
2 | Q60953 (/IDA) Q60953 (/IDA) |
|
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
2 | Q60953 (/ISS) Q60953 (/ISS) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Cell fate commitment GO:0045165
The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Negative regulation of mitotic cell cycle GO:0045930
Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Positive regulation of fibroblast proliferation GO:0048146
Any process that activates or increases the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Retinoic acid receptor signaling pathway GO:0048384
The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Negative regulation of interleukin-1 secretion GO:0050711
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 from a cell.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Negative regulation of interleukin-1 beta secretion GO:0050713
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Maintenance of protein location in nucleus GO:0051457
Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Negative regulation of telomerase activity GO:0051974
Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Positive regulation of apoptotic process involved in mammary gland involution GO:0060058
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process of mammary epithelial cells during mammary gland involution.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Branching involved in mammary gland duct morphogenesis GO:0060444
The process in which the branching structure of the mammary gland duct is generated and organized. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Cellular response to interleukin-4 GO:0071353
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-4 stimulus.
|
2 | Q60953 (/IDA) Q60953 (/IDA) |
|
Intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Cellular senescence GO:0090398
A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Cellular senescence GO:0090398
A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.
|
2 | Q60953 (/ISS) Q60953 (/ISS) |
|
Extrinsic apoptotic signaling pathway GO:0097191
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Negative regulation of viral release from host cell GO:1902187
Any process that stops, prevents or reduces the frequency, rate or extent of viral release from host cell.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Positive regulation of protein localization to chromosome, telomeric region GO:1904816
Any process that activates or increases the frequency, rate or extent of protein localization to chromosome, telomeric region.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Cellular response to leukemia inhibitory factor GO:1990830
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
|
2 | Q60953 (/IEP) Q60953 (/IEP) |
|
Negative regulation of ubiquitin-dependent protein catabolic process GO:2000059
Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Regulation of double-strand break repair GO:2000779
Any process that modulates the frequency, rate or extent of double-strand break repair.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Regulation of double-strand break repair GO:2000779
Any process that modulates the frequency, rate or extent of double-strand break repair.
|
2 | Q60953 (/ISS) Q60953 (/ISS) |
|
Positive regulation of apoptotic signaling pathway GO:2001235
Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.
|
2 | Q60953 (/IGI) Q60953 (/IGI) |
|
Positive regulation of apoptotic signaling pathway GO:2001235
Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
Positive regulation of extrinsic apoptotic signaling pathway GO:2001238
Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | P29590 (/IDA) |
|
Regulation of protein phosphorylation GO:0001932
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
|
1 | P29590 (/ISS) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P29590 (/IMP) |
|
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
|
1 | P29590 (/ISS) |
|
Regulation of calcium ion transport into cytosol GO:0010522
Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components.
|
1 | P29590 (/ISS) |
|
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
|
1 | P29590 (/IDA) |
|
PML body organization GO:0030578
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia).
|
1 | P29590 (/IMP) |
|
Positive regulation of telomere maintenance GO:0032206
Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.
|
1 | P29590 (/IMP) |
|
Endoplasmic reticulum calcium ion homeostasis GO:0032469
Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings.
|
1 | P29590 (/ISS) |
|
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
|
1 | P29590 (/ISS) |
|
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
|
1 | P29590 (/IDA) |
|
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
|
1 | P29590 (/ISS) |
|
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
|
1 | P29590 (/ISS) |
|
Entrainment of circadian clock by photoperiod GO:0043153
The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).
|
1 | P29590 (/ISS) |
|
Proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
1 | P29590 (/IDA) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P29590 (/IDA) |
|
Maintenance of protein location in nucleus GO:0051457
Any process in which a protein is maintained in the nucleus and prevented from moving elsewhere. These include sequestration within the nucleus, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the nucleus.
|
1 | P29590 (/IDA) |
|
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
|
1 | P29590 (/TAS) |
|
Protein-containing complex assembly GO:0065003
The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex.
|
1 | P29590 (/IDA) |
|
Cellular senescence GO:0090398
A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.
|
1 | P29590 (/IDA) |
|
Regulation of signal transduction by p53 class mediator GO:1901796
Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.
|
1 | P29590 (/TAS) |
|
Negative regulation of ubiquitin-dependent protein catabolic process GO:2000059
Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process
|
1 | P29590 (/IMP) |
|
Regulation of double-strand break repair GO:2000779
Any process that modulates the frequency, rate or extent of double-strand break repair.
|
1 | P29590 (/IMP) |
|
Negative regulation of extrinsic apoptotic signaling pathway GO:2001237
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway.
|
1 | Q15156 (/IMP) |
|
Positive regulation of extrinsic apoptotic signaling pathway GO:2001238
Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway.
|
1 | P29590 (/IMP) |
There are 26 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
14 |
Q15JD3 (/ISS)
Q15JD4 (/ISS)
Q15JD5 (/ISS)
Q15JD6 (/ISS)
Q15JD7 (/ISS)
Q15JD8 (/ISS)
Q15JD9 (/ISS)
Q15JE0 (/ISS)
Q15JE1 (/ISS)
Q15JE1 (/ISS)
(4 more) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
14 |
Q15JD3 (/ISS)
Q15JD4 (/ISS)
Q15JD5 (/ISS)
Q15JD6 (/ISS)
Q15JD7 (/ISS)
Q15JD8 (/ISS)
Q15JD9 (/ISS)
Q15JE0 (/ISS)
Q15JE1 (/ISS)
Q15JE1 (/ISS)
(4 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | A0A0D9RNP7 (/IDA) P29590 (/IDA) Q60953 (/IDA) Q60953 (/IDA) |
|
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
|
3 | P29590 (/IDA) Q60953 (/IDA) Q60953 (/IDA) |
|
Nuclear chromosome, telomeric region GO:0000784
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q60953 (/IDA) Q60953 (/IDA) |
|
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
|
2 | Q60953 (/IDA) Q60953 (/IDA) |
|
Nuclear matrix GO:0016363
The dense fibrillar network lying on the inner side of the nuclear membrane.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
|
2 | Q60953 (/IMP) Q60953 (/IMP) |
|
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
|
2 | Q60953 (/ISO) Q60953 (/ISO) |
|
Extrinsic component of endoplasmic reticulum membrane GO:0042406
The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
2 | Q60953 (/IDA) Q60953 (/IDA) |
|
Nuclear chromosome, telomeric region GO:0000784
The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins.
|
1 | P29590 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | P29590 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | P29590 (/TAS) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
1 | P29590 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P29590 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P29590 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P29590 (/TAS) |
|
PML body GO:0016605
A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection.
|
1 | P29590 (/TAS) |
|
Death-inducing signaling complex GO:0031264
A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10.
|
1 | Q15156 (/IDA) |
|
Extrinsic component of endoplasmic reticulum membrane GO:0042406
The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
|
1 | P29590 (/ISS) |
