The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Zinc/RING finger domain, C3HC4 (zinc finger)
".
FunFam 108: E3 ubiquitin-protein ligase MARCH7 isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ubiquitin binding GO:0043130
Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
|
3 | Q5R9W2 (/ISS) Q5XI50 (/ISS) Q9H992 (/ISS) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
1 | Q9WV66 (/IPI) |
|
Ubiquitin conjugating enzyme binding GO:0031624
Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins.
|
1 | Q9H992 (/IPI) |
|
Ubiquitin conjugating enzyme binding GO:0031624
Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins.
|
1 | Q9WV66 (/ISO) |
|
Ubiquitin binding GO:0043130
Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
|
1 | Q9WV66 (/IMP) |
|
MDM2/MDM4 family protein binding GO:0097371
Interacting selectively and non-covalently with any isoform of the MDM2/MDM4 protein family, comprising negative regulators of p53.
|
1 | Q9H992 (/IPI) |
|
MDM2/MDM4 family protein binding GO:0097371
Interacting selectively and non-covalently with any isoform of the MDM2/MDM4 protein family, comprising negative regulators of p53.
|
1 | Q9WV66 (/ISO) |
There are 25 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
3 | Q5R9W2 (/ISS) Q5XI50 (/ISS) Q9WV66 (/ISS) |
|
Negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518
Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
|
3 | Q5R9W2 (/ISS) Q5XI50 (/ISS) Q9WV66 (/ISS) |
|
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
3 | Q5R9W2 (/ISS) Q5XI50 (/ISS) Q9WV66 (/ISS) |
|
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
3 | Q5R9W2 (/ISS) Q5XI50 (/ISS) Q9H992 (/ISS) |
|
Negative regulation of proteasomal protein catabolic process GO:1901799
Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process.
|
3 | Q5R9W2 (/ISS) Q5XI50 (/ISS) Q9WV66 (/ISS) |
|
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator.
|
3 | Q5R9W2 (/ISS) Q5XI50 (/ISS) Q9WV66 (/ISS) |
|
Positive regulation of protein polyubiquitination GO:1902916
Any process that activates or increases the frequency, rate or extent of protein polyubiquitination.
|
3 | Q5R9W2 (/ISS) Q5XI50 (/ISS) Q9WV66 (/ISS) |
|
Negative regulation of protein autoubiquitination GO:1905524
Any process that stops, prevents or reduces the frequency, rate or extent of protein autoubiquitination.
|
3 | Q5R9W2 (/ISS) Q5XI50 (/ISS) Q9WV66 (/ISS) |
|
Regulation of tolerance induction GO:0002643
Any process that modulates the frequency, rate, or extent of tolerance induction.
|
1 | Q9WV66 (/IMP) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | Q9H992 (/IMP) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | Q9WV66 (/ISO) |
|
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
|
1 | Q9WV66 (/IMP) |
|
Negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518
Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
|
1 | Q9H992 (/IMP) |
|
Negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518
Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
|
1 | Q9WV66 (/ISO) |
|
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
1 | Q9H992 (/IMP) |
|
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
1 | Q9WV66 (/ISO) |
|
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
1 | Q9WV66 (/IMP) |
|
Negative regulation of proteasomal protein catabolic process GO:1901799
Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process.
|
1 | Q9H992 (/IMP) |
|
Negative regulation of proteasomal protein catabolic process GO:1901799
Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process.
|
1 | Q9WV66 (/ISO) |
|
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator.
|
1 | Q9H992 (/IMP) |
|
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator.
|
1 | Q9WV66 (/ISO) |
|
Positive regulation of protein polyubiquitination GO:1902916
Any process that activates or increases the frequency, rate or extent of protein polyubiquitination.
|
1 | Q9H992 (/IMP) |
|
Positive regulation of protein polyubiquitination GO:1902916
Any process that activates or increases the frequency, rate or extent of protein polyubiquitination.
|
1 | Q9WV66 (/ISO) |
|
Negative regulation of protein autoubiquitination GO:1905524
Any process that stops, prevents or reduces the frequency, rate or extent of protein autoubiquitination.
|
1 | Q9H992 (/IMP) |
|
Negative regulation of protein autoubiquitination GO:1905524
Any process that stops, prevents or reduces the frequency, rate or extent of protein autoubiquitination.
|
1 | Q9WV66 (/ISO) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
4 | Q5R9W2 (/ISS) Q5XI50 (/ISS) Q9H992 (/ISS) Q9WV66 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | Q5R9W2 (/ISS) Q5XI50 (/ISS) Q9H992 (/ISS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | Q5R9W2 (/ISS) Q5XI50 (/ISS) Q9H992 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q9H992 (/IDA) Q9WV66 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q9WV66 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9WV66 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q9WV66 (/IDA) |
