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CATH Superfamily 3.30.310.50

Alpha-D-phosphohexomutase, C-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Alpha-D-phosphohexomutase, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22: Phosphoglucosamine mutase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phosphoglucosamine mutase. [EC: 5.4.2.10]
Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate.
  • The enzyme is involved in the pathway for bacterial cell-wall peptidoglycan and lipopolysaccharide biosyntheses, being an essential step in the pathway for UDP-N-acetylglucosamine biosynthesis.
  • The enzyme from Escherichia coli is activated by phosphorylation and can be autophosphorylated in vitro by alpha-D-glucosamine 1,6- bisphosphate, which is an intermediate in the reaction, alpha-D- glucose 1,6-bisphosphate or ATP.
  • It can also catalyze the interconversion of alpha-D-glucose 1-phosphate and alpha-D-glucose 6-phosphate, although at a much lower rate.
 9 A5IKN6 A5IKN6 B1L9W8 G4FH98 G4FH98 Q5CBI5 Q5CBI5 Q9WY28 Q9WY28
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