The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Acetyl-coenzyme A synthetase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Acetate-CoA ligase activity GO:0003987
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
71 G3V9U0 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA)
(61 more)
Protein deacetylase activity GO:0033558
Catalysis of the hydrolysis of an acetyl group or groups from a protein substrate.
65 P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA)
(55 more)
Propionate-CoA ligase activity GO:0050218
Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA.
65 P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA)
(55 more)
Acetate-CoA ligase activity GO:0003987
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
14 Q54Z60 (/ISS) Q5LSF5 (/ISS) Q606H4 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS)
(4 more)
Acetate-CoA ligase activity GO:0003987
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
3 O94049 (/ISA) O94049 (/ISA) Q8NJN3 (/ISA)
Acid-ammonia (or amide) ligase activity GO:0016880
Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
3 P52910 (/IDA) P52910 (/IDA) Q01574 (/IDA)
Acetate-CoA ligase activity GO:0003987
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
2 P78773 (/ISO) Q9QXG4 (/ISO)
Catalytic activity GO:0003824
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
1 Q57XD7 (/ISM)
Acetate-CoA ligase activity GO:0003987
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
1 Q8NJN3 (/IGI)
Acetate-CoA ligase activity GO:0003987
Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
1 B9DGD6 (/IMP)
Showing 1 to 10 of 16 entries

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Acetate catabolic process GO:0045733
The chemical reactions and pathways resulting in the breakdown of acetate, the anion of acetic acid.
66 P16928 (/IMP) P27550 (/IMP) P27550 (/IMP) P27550 (/IMP) P27550 (/IMP) P27550 (/IMP) P27550 (/IMP) P27550 (/IMP) P27550 (/IMP) P27550 (/IMP)
(56 more)
Peptidyl-lysine acetylation GO:0018394
The acetylation of peptidyl-lysine.
65 P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA)
(55 more)
Post-translational protein acetylation GO:0034421
The addition of an acetyl group to one or more amino acids in a protein, occurring after the protein has been completely translated and released from the ribosome.
65 P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA)
(55 more)
Acetyl-CoA biosynthetic process from acetate GO:0019427
The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate.
11 Q885K7 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS) Q885K7 (/ISS) Q8EDK3 (/ISS) Q9KV59 (/ISS)
(1 more)
Acetyl-CoA biosynthetic process GO:0006085
The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.
4 P52910 (/IDA) P52910 (/IDA) Q01574 (/IDA) Q9QXG4 (/IDA)
Acetyl-CoA biosynthetic process GO:0006085
The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.
3 O94049 (/ISA) O94049 (/ISA) Q8NJN3 (/ISA)
Replicative cell aging GO:0001302
The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division.
2 P52910 (/IMP) P52910 (/IMP)
Histone acetylation GO:0016573
The modification of a histone by the addition of an acetyl group.
2 P52910 (/IMP) P52910 (/IMP)
Ethanol oxidation GO:0006069
An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate.
1 Q9NR19 (/TAS)
Acetate metabolic process GO:0006083
The chemical reactions and pathways involving acetate, the anion of acetic acid.
1 B9DGD6 (/IMP)
Showing 1 to 10 of 29 entries

There are 26 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
72 B9DGD6 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA) P27550 (/IDA)
(62 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 G3V9U0 (/IDA) P78773 (/IDA) Q57XD7 (/IDA) Q9QXG4 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P52910 (/IDA) P52910 (/IDA) P78773 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q4QBC0 (/ISO) Q9QXG4 (/ISO) Q9U0W1 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 O94049 (/ISA) O94049 (/ISA) Q8NJN3 (/ISA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
2 P52910 (/IDA) P52910 (/IDA)
Nuclear lumen GO:0031981
The volume enclosed by the nuclear inner membrane.
2 Q4QBC0 (/ISO) Q9U0W1 (/ISO)
Ciliary plasm GO:0097014
All of the contents of a cilium, excluding the plasma membrane surrounding the cilium.
2 Q4QBC0 (/ISO) Q9U0W1 (/ISO)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P16928 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P78773 (/HDA)
Showing 1 to 10 of 26 entries
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