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CATH Superfamily 3.30.2410.10

Hect, E3 ligase catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Hect, E3 ligase catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
SC:1E3 ubiquitin-protein ligase NEDD4-likeE3 ubiquitin-protein ligase HUWE1, variantPutative E3 ubiquitin-protein ligase UBR5E3 ubiquitin-protein ligase SMURF1E3 ubiquitin-protein ligase HECW2probable E3 ubiquitin-protein ligase HERC4 isoform X1E3 ubiquitin-protein ligase TRIP12 isoform X1probable E3 ubiquitin-protein ligase HERC1 isoform X2Putative E3 ubiquitin-protein ligase HECTD1Probable E3 ubiquitin-protein ligase HECTD2E3 ubiquitin-protein ligase UPL1Putative Ubiquitin-protein ligase E3CUbiquitin-protein ligase E3BApoptosis-resistant E3 ubiquitin protein ligase 1probable E3 ubiquitin-protein ligase HECTD4 isoform X1E3 ubiquitin-protein ligase HACE1 isoform X1E3 ubiquitin-protein ligase UPL7Putative E3 ubiquitin-protein ligase HECTD3G2/M-phase specific E3 ubiquitin protein ligaseE3 ubiquitin-protein ligase UPL5Putative ubiquitin-protein ligaseUnplaced genomic scaffold supercont1.2, whole genome shotgun sequenceE3 ubiquitin-protein ligaseE3 ubiquitin-protein ligase hecw-1Ubiquitin ligase (E3)Zn-finger in Ran binding protein and others/SPRY domain/HECT-domain (Ubiquitin-transferase), putativeE3 ubiquitin-protein ligase HUWE1Ubiquitin protein ligase, putativeUbiquitin protein ligase E3APredicted proteinHectd1 proteinE3 ubiquitin-protein ligase HACE1Predicted proteinWWP1 isoform 12E3 ubiquitin-protein ligaseUbiquitin-protein ligase, putativeE3 ubiquitin-protein ligase pub2HECT-domain ubiquitin--protein ligase E3E3 ubiquitin-protein ligase HACE1Ubiquitin protein ligase E3 component n-recognin 5Uncharacterized proteinMKIAA1625 proteinUncharacterized proteinUncharacterized proteinPredicted proteinUbiquitin-protein ligase E3BE3 ubiquitin-protein ligaseE3 ubiquitin-protein ligaseThyroid hormone receptor interactor 12E3 ubiquitin-protein ligase etc-1Probable E3 ubiquitin protein ligase C167.07cProbable E3 ubiquitin-protein ligase mug30Uncharacterized proteinProtein CBG00511Uncharacterized proteinNeural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligaseNeural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinUncharacterized proteinPredicted proteinUncharacterized protein
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FunFam 50: E3 ubiquitin-protein ligase etc-1

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC TermAnnotationsEvidence
HECT-type E3 ubiquitin transferase. [EC: 2.3.2.26]
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)- ubiquitinyl-[acceptor protein]-L-lysine.
  • In the first step the enzyme transfers ubiquitin from the E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) to a cysteine residue in its HECT domain (which is located in the C-terminal region), forming a thioester bond.
  • In a subsequent step the enzyme transfers the ubiquitin to an acceptor protein, resulting in the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon- amino group of an L-lysine residue of the acceptor protein.
  • Cf. EC 2.3.2.27 and EC 2.3.2.31.
 1 O17736
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