The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Hect, E3 ligase catalytic domain
".
FunFam 16: E3 ubiquitin-protein ligase HACE1 isoform X1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
8 | D3ZBM7 (/ISS) E1C656 (/ISS) F1N6G5 (/ISS) F8W2M1 (/ISS) Q28BK1 (/ISS) Q3U0D9 (/ISS) Q6DCL5 (/ISS) Q6DCL5 (/ISS) |
|
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
|
8 | D3ZBM7 (/ISS) E1C656 (/ISS) F1N6G5 (/ISS) F8W2M1 (/ISS) Q28BK1 (/ISS) Q3U0D9 (/ISS) Q6DCL5 (/ISS) Q6DCL5 (/ISS) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
3 | Q8IYU2 (/IDA) Q8IYU2 (/IDA) Q8IYU2 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | Q8IYU2 (/IPI) Q8IYU2 (/IPI) Q8IYU2 (/IPI) |
|
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
|
3 | Q8IYU2 (/IDA) Q8IYU2 (/IDA) Q8IYU2 (/IDA) |
|
Rac GTPase binding GO:0048365
Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.
|
3 | Q8IYU2 (/IPI) Q8IYU2 (/IPI) Q8IYU2 (/IPI) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | Q3U0D9 (/ISO) |
|
Rab GTPase binding GO:0017137
Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases.
|
1 | Q3U0D9 (/ISO) |
|
Rac GTPase binding GO:0048365
Interacting selectively and non-covalently with Rac protein, any member of the Rac subfamily of the Ras superfamily of monomeric GTPases.
|
1 | Q3U0D9 (/ISO) |
Showing 1 to 9 of 9 entries
There are 24 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
8 | D3ZBM7 (/ISS) E1C656 (/ISS) F1N6G5 (/ISS) F8W2M1 (/ISS) Q28BK1 (/ISS) Q3U0D9 (/ISS) Q6DCL5 (/ISS) Q6DCL5 (/ISS) |
|
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
|
8 | D3ZBM7 (/ISS) E1C656 (/ISS) F1N6G5 (/ISS) F8W2M1 (/ISS) Q28BK1 (/ISS) Q3U0D9 (/ISS) Q6DCL5 (/ISS) Q6DCL5 (/ISS) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
8 | D3ZBM7 (/ISS) E1C656 (/ISS) F1N6G5 (/ISS) F8W2M1 (/ISS) Q28BK1 (/ISS) Q3U0D9 (/ISS) Q6DCL5 (/ISS) Q6DCL5 (/ISS) |
|
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
|
8 | D3ZBM7 (/ISS) E1C656 (/ISS) F1N6G5 (/ISS) F8W2M1 (/ISS) Q28BK1 (/ISS) Q3U0D9 (/ISS) Q6DCL5 (/ISS) Q6DCL5 (/ISS) |
|
Membrane fusion GO:0061025
The membrane organization process that joins two lipid bilayers to form a single membrane.
|
8 | D3ZBM7 (/ISS) E1C656 (/ISS) F1N6G5 (/ISS) F8W2M1 (/ISS) Q28BK1 (/ISS) Q3U0D9 (/ISS) Q6DCL5 (/ISS) Q6DCL5 (/ISS) |
|
Protein K48-linked ubiquitination GO:0070936
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation.
|
8 | D3ZBM7 (/ISS) E1C656 (/ISS) F1N6G5 (/ISS) F8W2M1 (/ISS) Q28BK1 (/ISS) Q3U0D9 (/ISS) Q6DCL5 (/ISS) Q6DCL5 (/ISS) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
3 | Q8IYU2 (/IDA) Q8IYU2 (/IDA) Q8IYU2 (/IDA) |
|
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
|
3 | Q8IYU2 (/IDA) Q8IYU2 (/IDA) Q8IYU2 (/IDA) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
3 | Q8IYU2 (/IDA) Q8IYU2 (/IDA) Q8IYU2 (/IDA) |
|
Rac protein signal transduction GO:0016601
A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state.
|
3 | Q8IYU2 (/TAS) Q8IYU2 (/TAS) Q8IYU2 (/TAS) |
Showing 1 to 10 of 24 entries
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
|
8 | D3ZBM7 (/ISS) E1C656 (/ISS) F1N6G5 (/ISS) F8W2M1 (/ISS) Q28BK1 (/ISS) Q3U0D9 (/ISS) Q6DCL5 (/ISS) Q6DCL5 (/ISS) |
|
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
|
3 | Q8IYU2 (/IDA) Q8IYU2 (/IDA) Q8IYU2 (/IDA) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
3 | Q8IYU2 (/IDA) Q8IYU2 (/IDA) Q8IYU2 (/IDA) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
3 | Q8IYU2 (/IDA) Q8IYU2 (/IDA) Q8IYU2 (/IDA) |
|
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
|
1 | Q3U0D9 (/ISO) |
|
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
|
1 | Q3U0D9 (/ISO) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
1 | Q3U0D9 (/ISO) |
Showing 1 to 7 of 7 entries
