The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Phosphorylase Kinase; domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 36: Tyrosine-protein kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 69 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
18 P06239 (/IPI) P06239 (/IPI) P06239 (/IPI) P06239 (/IPI) P06239 (/IPI) P06240 (/IPI) P07948 (/IPI) P07948 (/IPI) P07948 (/IPI) P08103 (/IPI)
(8 more)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
14 P06239 (/IDA) P06239 (/IDA) P06239 (/IDA) P06239 (/IDA) P06239 (/IDA) P06240 (/IDA) P07948 (/IDA) P07948 (/IDA) P07948 (/IDA) P25911 (/IDA)
(4 more)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
14 P06239 (/TAS) P06239 (/TAS) P06239 (/TAS) P06239 (/TAS) P06239 (/TAS) P07948 (/TAS) P07948 (/TAS) P07948 (/TAS) P08631 (/TAS) P08631 (/TAS)
(4 more)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
11 P06240 (/ISS) P08103 (/ISS) P08103 (/ISS) P16277 (/ISS) P42683 (/ISS) P50545 (/ISS) Q3ZCM0 (/ISS) Q5PXS1 (/ISS) Q95KR7 (/ISS) Q95M30 (/ISS)
(1 more)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
10 P06239 (/EXP) P06239 (/EXP) P06239 (/EXP) P06239 (/EXP) P06239 (/EXP) P07948 (/EXP) P07948 (/EXP) P07948 (/EXP) P25911 (/EXP) P25911 (/EXP)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
8 P06239 (/IMP) P06239 (/IMP) P06239 (/IMP) P06239 (/IMP) P06239 (/IMP) P06240 (/IMP) P08631 (/IMP) P08631 (/IMP)
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
7 P06239 (/IPI) P06239 (/IPI) P06239 (/IPI) P06239 (/IPI) P06239 (/IPI) P08631 (/IPI) P08631 (/IPI)
CD4 receptor binding GO:0042609
Interacting selectively and non-covalently with a CD4, a receptor found on the surface of T cells, monocytes and macrophages.
7 P06239 (/IPI) P06239 (/IPI) P06239 (/IPI) P06239 (/IPI) P06239 (/IPI) P06240 (/IPI) W5U6C9 (/IPI)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
6 P06240 (/ISO) P08103 (/ISO) P08103 (/ISO) P16277 (/ISO) P25911 (/ISO) P25911 (/ISO)
Protein serine/threonine phosphatase activity GO:0004722
Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
6 P06240 (/ISS) P42683 (/ISS) Q3ZCM0 (/ISS) Q5PXS1 (/ISS) Q95KR7 (/ISS) Q95M32 (/ISS)
Showing 1 to 10 of 69 entries

There are 234 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
9 P06239 (/IDA) P06239 (/IDA) P06239 (/IDA) P06239 (/IDA) P06239 (/IDA) P06240 (/IDA) P07948 (/IDA) P07948 (/IDA) P07948 (/IDA)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
9 O13064 (/ISS) P07948 (/ISS) P07948 (/ISS) P07948 (/ISS) P08103 (/ISS) P08103 (/ISS) P50545 (/ISS) Q07014 (/ISS) Q95M30 (/ISS)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
8 P06240 (/IDA) P07948 (/IDA) P07948 (/IDA) P07948 (/IDA) P25911 (/IDA) P25911 (/IDA) P51451 (/IDA) Q01621 (/IDA)
Platelet activation GO:0030168
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
8 P06239 (/TAS) P06239 (/TAS) P06239 (/TAS) P06239 (/TAS) P06239 (/TAS) P07948 (/TAS) P07948 (/TAS) P07948 (/TAS)
T cell costimulation GO:0031295
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.
8 P06239 (/TAS) P06239 (/TAS) P06239 (/TAS) P06239 (/TAS) P06239 (/TAS) P07948 (/TAS) P07948 (/TAS) P07948 (/TAS)
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
8 P06239 (/TAS) P06239 (/TAS) P06239 (/TAS) P06239 (/TAS) P06239 (/TAS) P07948 (/TAS) P07948 (/TAS) P07948 (/TAS)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
7 P06239 (/IMP) P06239 (/IMP) P06239 (/IMP) P06239 (/IMP) P06239 (/IMP) P08631 (/IMP) P08631 (/IMP)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
7 P06240 (/IDA) P07948 (/IDA) P07948 (/IDA) P07948 (/IDA) P25911 (/IDA) P25911 (/IDA) Q01621 (/IDA)
Regulation of defense response to virus by virus GO:0050690
Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism.
7 P06239 (/TAS) P06239 (/TAS) P06239 (/TAS) P06239 (/TAS) P06239 (/TAS) P08631 (/TAS) P08631 (/TAS)
Cellular zinc ion homeostasis GO:0006882
Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell.
6 P06240 (/ISS) P42683 (/ISS) Q3ZCM0 (/ISS) Q5PXS1 (/ISS) Q95KR7 (/ISS) Q95M32 (/ISS)
Showing 1 to 10 of 234 entries

There are 58 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO TermAnnotationsEvidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
17 H0Y3C5 (/IDA) J3KPD6 (/IDA) P06239 (/IDA) P06239 (/IDA) P06239 (/IDA) P06239 (/IDA) P06239 (/IDA) P07948 (/IDA) P07948 (/IDA) P07948 (/IDA)
(7 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
15 P06239 (/TAS) P06239 (/TAS) P06239 (/TAS) P06239 (/TAS) P06239 (/TAS) P06240 (/TAS) P07948 (/TAS) P07948 (/TAS) P07948 (/TAS) P08631 (/TAS)
(5 more)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
12 P06239 (/IDA) P06239 (/IDA) P06239 (/IDA) P06239 (/IDA) P06239 (/IDA) P07948 (/IDA) P07948 (/IDA) P07948 (/IDA) P25911 (/IDA) P25911 (/IDA)
(2 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 P06239 (/TAS) P06239 (/TAS) P06239 (/TAS) P06239 (/TAS) P06239 (/TAS) P07948 (/TAS) P07948 (/TAS) P07948 (/TAS) Q5ZMB9 (/TAS)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
9 P06240 (/ISS) P07948 (/ISS) P07948 (/ISS) P07948 (/ISS) P42683 (/ISS) Q3ZCM0 (/ISS) Q5PXS1 (/ISS) Q95KR7 (/ISS) Q95M32 (/ISS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
8 P06239 (/HDA) P06239 (/HDA) P06239 (/HDA) P06239 (/HDA) P06239 (/HDA) P07948 (/HDA) P07948 (/HDA) P07948 (/HDA)
Pericentriolar material GO:0000242
A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome.
6 P06240 (/ISS) P42683 (/ISS) Q3ZCM0 (/ISS) Q5PXS1 (/ISS) Q95KR7 (/ISS) Q95M32 (/ISS)
Pericentriolar material GO:0000242
A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome.
5 P06239 (/IDA) P06239 (/IDA) P06239 (/IDA) P06239 (/IDA) P06239 (/IDA)
Immunological synapse GO:0001772
An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.
5 P06239 (/IDA) P06239 (/IDA) P06239 (/IDA) P06239 (/IDA) P06239 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 P07948 (/IDA) P07948 (/IDA) P07948 (/IDA) P25911 (/IDA) P25911 (/IDA)
Showing 1 to 10 of 58 entries
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